| Titre : |
Exploration des potentialites therapeutiques de la phytopharmacopee traditionnelle algerienne : Etude de quelques plantes a activite cicatrisante. |
| Type de document : |
texte imprimé |
| Auteurs : |
Ahmed Boukeloua, Auteur ; Abdelmalik Belkhiri, Directeur de thèse |
| Editeur : |
جامعة الإخوة منتوري قسنطينة |
| Année de publication : |
2016 |
| Importance : |
158 f. |
| Format : |
30 cm. |
| Note générale : |
2 copies imprimées disponibles
|
| Langues : |
Français (fre) |
| Catégories : |
Français - Anglais
Biologie
|
| Tags : |
Biologie et écologie végétale:Biotechnologie Végétale Argania spinosa Opuntia ficus-indica Pistacia lentiscus préparation huileuse composition effet cicatrisant plaies d’excision lapins oily préparation wound heaking effet excised wound rabbits لمستحضرات الزيتية التركيب فعالية التئام الجروح الأرنب |
| Index. décimale : |
570 Sciences de la vie. Biologie |
| Résumé : |
The wound healing potentialities of traditional Algerian phyto-pharmacopeia lie usually in some oily preparations, that their nutritional and pharmacological properties are related to an overall and synergic action of their bioactive constituents. This study resets on measuring of some physico-chemical and phytochemical parameters (chromatography HPlC, GC-MS and LC-MS/MS) of argane oil (HAS), of lipophylic extracts obtained from lentiscus fruits (EHPL) and Barbary fig seeds (EHOFI), and alcoholic extracts (EA) from the three plants, as well as a toxico-pharmacological evaluation of three oily preparations in animal (mousse, rabbit).
Obtained hysico-chemical parameters for the three oily preparations are comparable to those
published for similar preparation. The phytochemical tests showed the relative high contents
In these three plants of lipophylic extracting material; of proteins (EHOFI 28.39, HAS 26.21
and EHPL 23.85%), of unsaturated fatty acids (HAS 88, EHOFI 81.2 and EHPL 74.15%), of
unsaponifiable [α-tocophérol (EHOFI 21.34, EHPL 15.8 et HAS 7.44mg/100g) ; et phytostérols (EHPL 261, EHOFI 146, et HAS 134 mg/100g)], of total phenols for EAAS (35.57mg/g) and high total flavonoïds for the three alcoholic extract. The quantification of main constituents showed that EHOFI is riche on -linolénic ac. (57 %), while the fatty acids oleic and linoleic are presents in high quantities in HAS (44.4 et 36,69 %) and EHPL (48.91 et 21,86 %) respectively. -sitostérol is the main constituent for the three oily preparations. EAPL extract showed a dominant presence of gallic ac. (2092,39µg/g), quinic ac. (1519,84 µg/g), while EAOFI showed the presence of quinic ac. (83,57 µg/g) and chlorogénic ac. (16,37µg/g), as high polyphénols contents. On the toxicological part, the three oily products tested on rabbits, are considered non irritant neither on eye and skin, nor on anal mucosa. Their acute toxicity study on mice showed an absence or low down toxicity of the three oily preparations, by oral and intraperitonel routes. The evaluation of wound healing activity of the three oily preparations on excised wounds on rabbits showed less convincing results for EHPL than those obtained for EHOFI and HAS. These two latter treatments promote significantly (p≤0.05*) wound healing process on rabbits wounds during all treatment period.
|
| Note de contenu : |
Article 1:Acute toxicity of Opuntia ficus indica and Pistacia lentiscusseed
oils in mice.A. Boukelouaa,e, A. Belkhirib, Z. Djerroua, L. Bahric, N. Boulebdad, Y. Hamdi Pachaa.
Article 2:Chemical profiling and total thickness-excised wound-healing activity of Pistacia lentiscus L. fruits growing in Algeria.Ahmed Boukeloua1*, Abdelmalik Belkhiri2, Mustafa Abdullah Yilmaz3 and Hamdi Temel4 |
| Diplôme : |
Doctorat en sciences |
| En ligne : |
../theses/biologie/BOU6978.pdf |
| Format de la ressource électronique : |
pdf |
| Permalink : |
index.php?lvl=notice_display&id=11124 |
Exploration des potentialites therapeutiques de la phytopharmacopee traditionnelle algerienne : Etude de quelques plantes a activite cicatrisante. [texte imprimé] / Ahmed Boukeloua, Auteur ; Abdelmalik Belkhiri, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2016 . - 158 f. ; 30 cm. 2 copies imprimées disponibles
Langues : Français ( fre)
| Catégories : |
Français - Anglais
Biologie
|
| Tags : |
Biologie et écologie végétale:Biotechnologie Végétale Argania spinosa Opuntia ficus-indica Pistacia lentiscus préparation huileuse composition effet cicatrisant plaies d’excision lapins oily préparation wound heaking effet excised wound rabbits لمستحضرات الزيتية التركيب فعالية التئام الجروح الأرنب |
| Index. décimale : |
570 Sciences de la vie. Biologie |
| Résumé : |
The wound healing potentialities of traditional Algerian phyto-pharmacopeia lie usually in some oily preparations, that their nutritional and pharmacological properties are related to an overall and synergic action of their bioactive constituents. This study resets on measuring of some physico-chemical and phytochemical parameters (chromatography HPlC, GC-MS and LC-MS/MS) of argane oil (HAS), of lipophylic extracts obtained from lentiscus fruits (EHPL) and Barbary fig seeds (EHOFI), and alcoholic extracts (EA) from the three plants, as well as a toxico-pharmacological evaluation of three oily preparations in animal (mousse, rabbit).
Obtained hysico-chemical parameters for the three oily preparations are comparable to those
published for similar preparation. The phytochemical tests showed the relative high contents
In these three plants of lipophylic extracting material; of proteins (EHOFI 28.39, HAS 26.21
and EHPL 23.85%), of unsaturated fatty acids (HAS 88, EHOFI 81.2 and EHPL 74.15%), of
unsaponifiable [α-tocophérol (EHOFI 21.34, EHPL 15.8 et HAS 7.44mg/100g) ; et phytostérols (EHPL 261, EHOFI 146, et HAS 134 mg/100g)], of total phenols for EAAS (35.57mg/g) and high total flavonoïds for the three alcoholic extract. The quantification of main constituents showed that EHOFI is riche on -linolénic ac. (57 %), while the fatty acids oleic and linoleic are presents in high quantities in HAS (44.4 et 36,69 %) and EHPL (48.91 et 21,86 %) respectively. -sitostérol is the main constituent for the three oily preparations. EAPL extract showed a dominant presence of gallic ac. (2092,39µg/g), quinic ac. (1519,84 µg/g), while EAOFI showed the presence of quinic ac. (83,57 µg/g) and chlorogénic ac. (16,37µg/g), as high polyphénols contents. On the toxicological part, the three oily products tested on rabbits, are considered non irritant neither on eye and skin, nor on anal mucosa. Their acute toxicity study on mice showed an absence or low down toxicity of the three oily preparations, by oral and intraperitonel routes. The evaluation of wound healing activity of the three oily preparations on excised wounds on rabbits showed less convincing results for EHPL than those obtained for EHOFI and HAS. These two latter treatments promote significantly (p≤0.05*) wound healing process on rabbits wounds during all treatment period.
|
| Note de contenu : |
Article 1:Acute toxicity of Opuntia ficus indica and Pistacia lentiscusseed
oils in mice.A. Boukelouaa,e, A. Belkhirib, Z. Djerroua, L. Bahric, N. Boulebdad, Y. Hamdi Pachaa.
Article 2:Chemical profiling and total thickness-excised wound-healing activity of Pistacia lentiscus L. fruits growing in Algeria.Ahmed Boukeloua1*, Abdelmalik Belkhiri2, Mustafa Abdullah Yilmaz3 and Hamdi Temel4 |
| Diplôme : |
Doctorat en sciences |
| En ligne : |
../theses/biologie/BOU6978.pdf |
| Format de la ressource électronique : |
pdf |
| Permalink : |
index.php?lvl=notice_display&id=11124 |
|
Affiner la recherche Interroger des sources externesCaractérisation botanique et chimique et évaluation pharmaco-toxicologique d'une préparation topique à base d'huile de Pistacia lentiscus L. (Anacardiaceae) / Ahmed Boukeloua
