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Partager le résultat de cette recherche Interroger des sources externesEvaluation des propriétés biopharmacologiques, standardisation chimique et valorisation des agroressources fonctionnelles cas de Vitis vinifera, Punica granatum, Citrus aurantium et Opuntia ficus-indica. / Nadia Zeghad ep Bououden
Titre : Evaluation des propriétés biopharmacologiques, standardisation chimique et valorisation des agroressources fonctionnelles cas de Vitis vinifera, Punica granatum, Citrus aurantium et Opuntia ficus-indica. Type de document : texte imprimé Auteurs : Nadia Zeghad ep Bououden, Auteur ; Abdelmalik Belkhiri, Directeur de thèse ; Kristiaan Demeyer, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2018 Importance : 149 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles. Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : Vitis vinifera Punica granatum Citrus aurantium Opuntia ficus-indica composés phénoliques activités biopharmacologiques phenolic compounds biopharmacological activities العنب Vitis vinifera الرمان Punica granatum البرتقال المر Citrus aurantium التين الشوكي Opuntia ficus-indica الأنشطة البيوفارماكولوجية المركبات الفينولية Index. décimale : 570 Sciences de la vie. Biologie Résumé : The present work was based on the valorization of agroresources of four fruits grown locally
in Algeria; Vitis vinifera, Punica granatum, Citrus aurantium and Opuntia ficus-indica by the
determination of their molecular characterizations and biological activities.
The hydroalcoholic extracts of the selected fruits were evaluated for their antioxidant,
analgesic, healing and antihyperlipidemic activities as well as their toxic potential.
A chromatographic analysis by HPLC-DAD-ESI/MS was performed and supplemented by a
quantitative evaluation of the total phenols, flavonoïds, flavonols, condensed and
hydrolysable tannins. The results of the quantitative analysis show that the levels of the of
Vitis vinifera fruit extract on phenolic compounds are significantly higher than those of other
fruits. The results of the HPLC-DAD-ESI/MS analysis revealed a chromatographic profile
dominated by a bargaptene (coumarin) for the extract of Punica granatum and by the phenolic
acids and flavonoïds for the other extracts.
The antioxidant activity (DPPH•, ABTS•+, FRAP, ORAC, TBARS, NO•) evaluated in vitro
showed that the antioxidant potential of the Vitis vinifera extract is the most important
compared to the other extracts. The Punica granatum extract has also a potential antioxidant
activity but it remains less important than that of the previous species.
The Vitis vinifera and Punica granatum extracts showed an analgesic effect on the three tests
(torsion, hot plate and tail immersion), of which the potential to reduce the pain was
statistically comparable in both extracts and was most evident in the torsion test. On the other
hand, the results of the evaluation of the healing activity in the rabbits showed that the Punica
granatum extract and at lesser degree that of Vitis vinifera accelerate the process of healing
of excisional wounds and burns compared to the control, and was even superior to that of
commercial healing cream (Cicatryl®). The results of the antihyperlipidemic activity showed
that the Vitis vinifera and Punica granatum extracts normalized the lipidemic profile in mice
made hyperlipidemic compared to the control. Finally, the results of the acute toxicity in mice
demonstrated that the Vitis vinifera and Punica granatum extracts are free of any signs of
toxicity at the maximum dose prescribed.
Diplôme : Doctorat en sciences En ligne : ../theses/biologie/ZEG7208.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10755 Evaluation des propriétés biopharmacologiques, standardisation chimique et valorisation des agroressources fonctionnelles cas de Vitis vinifera, Punica granatum, Citrus aurantium et Opuntia ficus-indica. [texte imprimé] / Nadia Zeghad ep Bououden, Auteur ; Abdelmalik Belkhiri, Directeur de thèse ; Kristiaan Demeyer, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2018 . - 149 f. ; 30 cm.
2 copies imprimées disponibles.
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Vitis vinifera Punica granatum Citrus aurantium Opuntia ficus-indica composés phénoliques activités biopharmacologiques phenolic compounds biopharmacological activities العنب Vitis vinifera الرمان Punica granatum البرتقال المر Citrus aurantium التين الشوكي Opuntia ficus-indica الأنشطة البيوفارماكولوجية المركبات الفينولية Index. décimale : 570 Sciences de la vie. Biologie Résumé : The present work was based on the valorization of agroresources of four fruits grown locally
in Algeria; Vitis vinifera, Punica granatum, Citrus aurantium and Opuntia ficus-indica by the
determination of their molecular characterizations and biological activities.
The hydroalcoholic extracts of the selected fruits were evaluated for their antioxidant,
analgesic, healing and antihyperlipidemic activities as well as their toxic potential.
A chromatographic analysis by HPLC-DAD-ESI/MS was performed and supplemented by a
quantitative evaluation of the total phenols, flavonoïds, flavonols, condensed and
hydrolysable tannins. The results of the quantitative analysis show that the levels of the of
Vitis vinifera fruit extract on phenolic compounds are significantly higher than those of other
fruits. The results of the HPLC-DAD-ESI/MS analysis revealed a chromatographic profile
dominated by a bargaptene (coumarin) for the extract of Punica granatum and by the phenolic
acids and flavonoïds for the other extracts.
The antioxidant activity (DPPH•, ABTS•+, FRAP, ORAC, TBARS, NO•) evaluated in vitro
showed that the antioxidant potential of the Vitis vinifera extract is the most important
compared to the other extracts. The Punica granatum extract has also a potential antioxidant
activity but it remains less important than that of the previous species.
The Vitis vinifera and Punica granatum extracts showed an analgesic effect on the three tests
(torsion, hot plate and tail immersion), of which the potential to reduce the pain was
statistically comparable in both extracts and was most evident in the torsion test. On the other
hand, the results of the evaluation of the healing activity in the rabbits showed that the Punica
granatum extract and at lesser degree that of Vitis vinifera accelerate the process of healing
of excisional wounds and burns compared to the control, and was even superior to that of
commercial healing cream (Cicatryl®). The results of the antihyperlipidemic activity showed
that the Vitis vinifera and Punica granatum extracts normalized the lipidemic profile in mice
made hyperlipidemic compared to the control. Finally, the results of the acute toxicity in mice
demonstrated that the Vitis vinifera and Punica granatum extracts are free of any signs of
toxicity at the maximum dose prescribed.
Diplôme : Doctorat en sciences En ligne : ../theses/biologie/ZEG7208.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10755 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité ZEG/7208 ZEG/7208 Thèse Bibliothèque principale Thèses Disponible
Titre : Exploration des potentialites therapeutiques de la phytopharmacopee traditionnelle algerienne : Etude de quelques plantes a activite cicatrisante. Type de document : texte imprimé Auteurs : Ahmed Boukeloua, Auteur ; Abdelmalik Belkhiri, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2016 Importance : 158 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : Biologie et écologie végétale:Biotechnologie Végétale Argania spinosa Opuntia ficus-indica Pistacia lentiscus préparation huileuse composition effet cicatrisant plaies d’excision lapins oily préparation wound heaking effet excised wound rabbits لمستحضرات الزيتية التركيب فعالية التئام الجروح الأرنب Index. décimale : 570 Sciences de la vie. Biologie Résumé : The wound healing potentialities of traditional Algerian phyto-pharmacopeia lie usually in some oily preparations, that their nutritional and pharmacological properties are related to an overall and synergic action of their bioactive constituents. This study resets on measuring of some physico-chemical and phytochemical parameters (chromatography HPlC, GC-MS and LC-MS/MS) of argane oil (HAS), of lipophylic extracts obtained from lentiscus fruits (EHPL) and Barbary fig seeds (EHOFI), and alcoholic extracts (EA) from the three plants, as well as a toxico-pharmacological evaluation of three oily preparations in animal (mousse, rabbit).
Obtained hysico-chemical parameters for the three oily preparations are comparable to those
published for similar preparation. The phytochemical tests showed the relative high contents
In these three plants of lipophylic extracting material; of proteins (EHOFI 28.39, HAS 26.21
and EHPL 23.85%), of unsaturated fatty acids (HAS 88, EHOFI 81.2 and EHPL 74.15%), of
unsaponifiable [α-tocophérol (EHOFI 21.34, EHPL 15.8 et HAS 7.44mg/100g) ; et phytostérols (EHPL 261, EHOFI 146, et HAS 134 mg/100g)], of total phenols for EAAS (35.57mg/g) and high total flavonoïds for the three alcoholic extract. The quantification of main constituents showed that EHOFI is riche on -linolénic ac. (57 %), while the fatty acids oleic and linoleic are presents in high quantities in HAS (44.4 et 36,69 %) and EHPL (48.91 et 21,86 %) respectively. -sitostérol is the main constituent for the three oily preparations. EAPL extract showed a dominant presence of gallic ac. (2092,39µg/g), quinic ac. (1519,84 µg/g), while EAOFI showed the presence of quinic ac. (83,57 µg/g) and chlorogénic ac. (16,37µg/g), as high polyphénols contents. On the toxicological part, the three oily products tested on rabbits, are considered non irritant neither on eye and skin, nor on anal mucosa. Their acute toxicity study on mice showed an absence or low down toxicity of the three oily preparations, by oral and intraperitonel routes. The evaluation of wound healing activity of the three oily preparations on excised wounds on rabbits showed less convincing results for EHPL than those obtained for EHOFI and HAS. These two latter treatments promote significantly (p≤0.05*) wound healing process on rabbits wounds during all treatment period.
Note de contenu :
Article 1:Acute toxicity of Opuntia ficus indica and Pistacia lentiscusseed
oils in mice.A. Boukelouaa,e, A. Belkhirib, Z. Djerroua, L. Bahric, N. Boulebdad, Y. Hamdi Pachaa.
Article 2:Chemical profiling and total thickness-excised wound-healing activity of Pistacia lentiscus L. fruits growing in Algeria.Ahmed Boukeloua1*, Abdelmalik Belkhiri2, Mustafa Abdullah Yilmaz3 and Hamdi Temel4Diplôme : Doctorat en sciences En ligne : ../theses/biologie/BOU6978.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11124 Exploration des potentialites therapeutiques de la phytopharmacopee traditionnelle algerienne : Etude de quelques plantes a activite cicatrisante. [texte imprimé] / Ahmed Boukeloua, Auteur ; Abdelmalik Belkhiri, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2016 . - 158 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Biologie et écologie végétale:Biotechnologie Végétale Argania spinosa Opuntia ficus-indica Pistacia lentiscus préparation huileuse composition effet cicatrisant plaies d’excision lapins oily préparation wound heaking effet excised wound rabbits لمستحضرات الزيتية التركيب فعالية التئام الجروح الأرنب Index. décimale : 570 Sciences de la vie. Biologie Résumé : The wound healing potentialities of traditional Algerian phyto-pharmacopeia lie usually in some oily preparations, that their nutritional and pharmacological properties are related to an overall and synergic action of their bioactive constituents. This study resets on measuring of some physico-chemical and phytochemical parameters (chromatography HPlC, GC-MS and LC-MS/MS) of argane oil (HAS), of lipophylic extracts obtained from lentiscus fruits (EHPL) and Barbary fig seeds (EHOFI), and alcoholic extracts (EA) from the three plants, as well as a toxico-pharmacological evaluation of three oily preparations in animal (mousse, rabbit).
Obtained hysico-chemical parameters for the three oily preparations are comparable to those
published for similar preparation. The phytochemical tests showed the relative high contents
In these three plants of lipophylic extracting material; of proteins (EHOFI 28.39, HAS 26.21
and EHPL 23.85%), of unsaturated fatty acids (HAS 88, EHOFI 81.2 and EHPL 74.15%), of
unsaponifiable [α-tocophérol (EHOFI 21.34, EHPL 15.8 et HAS 7.44mg/100g) ; et phytostérols (EHPL 261, EHOFI 146, et HAS 134 mg/100g)], of total phenols for EAAS (35.57mg/g) and high total flavonoïds for the three alcoholic extract. The quantification of main constituents showed that EHOFI is riche on -linolénic ac. (57 %), while the fatty acids oleic and linoleic are presents in high quantities in HAS (44.4 et 36,69 %) and EHPL (48.91 et 21,86 %) respectively. -sitostérol is the main constituent for the three oily preparations. EAPL extract showed a dominant presence of gallic ac. (2092,39µg/g), quinic ac. (1519,84 µg/g), while EAOFI showed the presence of quinic ac. (83,57 µg/g) and chlorogénic ac. (16,37µg/g), as high polyphénols contents. On the toxicological part, the three oily products tested on rabbits, are considered non irritant neither on eye and skin, nor on anal mucosa. Their acute toxicity study on mice showed an absence or low down toxicity of the three oily preparations, by oral and intraperitonel routes. The evaluation of wound healing activity of the three oily preparations on excised wounds on rabbits showed less convincing results for EHPL than those obtained for EHOFI and HAS. These two latter treatments promote significantly (p≤0.05*) wound healing process on rabbits wounds during all treatment period.
Note de contenu :
Article 1:Acute toxicity of Opuntia ficus indica and Pistacia lentiscusseed
oils in mice.A. Boukelouaa,e, A. Belkhirib, Z. Djerroua, L. Bahric, N. Boulebdad, Y. Hamdi Pachaa.
Article 2:Chemical profiling and total thickness-excised wound-healing activity of Pistacia lentiscus L. fruits growing in Algeria.Ahmed Boukeloua1*, Abdelmalik Belkhiri2, Mustafa Abdullah Yilmaz3 and Hamdi Temel4Diplôme : Doctorat en sciences En ligne : ../theses/biologie/BOU6978.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11124 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité BOU/6978 BOU/6978 Thèse Bibliothèque principale Thèses Disponible
