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Auteur Naim Akhtar Khan |
Documents disponibles écrits par cet auteur (2)
Affiner la recherche Interroger des sources externesComportement alimentaire et signalisation via le récepteur TGR5 de l’homéostasie lipido-glucidique et énergétique et polymorphisme dans l’obésité. / Adel Bensalem
Titre : Comportement alimentaire et signalisation via le récepteur TGR5 de l’homéostasie lipido-glucidique et énergétique et polymorphisme dans l’obésité. Type de document : texte imprimé Auteurs : Adel Bensalem, Auteur ; Abdel-Nacer Agli, Directeur de thèse ; Naim Akhtar Khan, Directeur de thèse Mention d'édition : 10/02/2021 Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2021 Importance : 181 f. Format : 30 cm. Note générale : 1 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
Nutrition, Alimentation et Technologies Agro-AlimentairesTags : Nutrition Humaine: Sciences Alimentaires obésité comportement alimentaire appétit repas récepteur TGR5 préférences alimentaires polymorphisme obesity eating behavior appetite meals TGR5 receptor dietary preferences polymorphism السمنة سلوك الغذائي الشهية الوجبة مستقبل TGR5التفضيلات الغذائية تعدد الأشكال الجيني Index. décimale : 640 Industrie Alimentaire Résumé :
Our work consists of studying the behavioral determinants of appetite and the involvement of the bile acid receptor TGR5 in the modulation of food preferences and its association with obesity. A survey on eating behavior and assessment of subjective and objective appetite was conducted among 208 young adults. Subjective feelings of appetite were estimated by scores on a visual analog scale and objective appetite was estimated by nutrient intake and interprandial intervals. The identification of a signaling pathway via the TGR5 receptor in lipid-glucidic homeostasis and its implication in the modulation of dietary preferences and in obesity was carried out in WT and TGR5-/- mice. The association of the TGR5 gene polymorphism with obesity has been investigated in 127 children. Food consumption depends on the subjective sensations of appetite, and the preprandial duration. Stress induces overconsumption of energy. Consumption habits and the importance given to meals favored more energy consumption. The subjective satiation score is associated with nutritional intake. The gustatory pleasure score is correlated with protein and lipid intake. Gastric fullness is correlated with fiber intake. The energy density of dishes has a positive influence on satiation and negatively on gastric fullness. Only the sensation of gustatory pleasure is influenced by the pleasantness of the dish served. Postprandial duration is positively correlated with subjective satiation score and gustatory pleasure, but not with gastric fullness.The proteins had presented a satiating effect and a satietogenic power more important, than those of the carbohydrates and the lipids. The deletion of the TGR5 gene associated with a high fat diet, leads to a decrease in energy expenditure, and an imbalance of carbohydrate-lipid and energy homeostasis, as well as a decrease in the secretion of GLP-1. To which are added inflammatory effects and hepatic steatosis. Indeed, TGR5 is also involved in the control of dietary fat intake through its involvement in the physiology of taste buds. The study of the single nucleotide polymorphism of TGR5 (SNP rs11554825) further confirms its involvement in childhood obesity.
Diplôme : Doctorat en sciences En ligne : ../theses/agronomie/BEN7712.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11546 Comportement alimentaire et signalisation via le récepteur TGR5 de l’homéostasie lipido-glucidique et énergétique et polymorphisme dans l’obésité. [texte imprimé] / Adel Bensalem, Auteur ; Abdel-Nacer Agli, Directeur de thèse ; Naim Akhtar Khan, Directeur de thèse . - 10/02/2021 . - جامعة الإخوة منتوري قسنطينة, 2021 . - 181 f. ; 30 cm.
1 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
Nutrition, Alimentation et Technologies Agro-AlimentairesTags : Nutrition Humaine: Sciences Alimentaires obésité comportement alimentaire appétit repas récepteur TGR5 préférences alimentaires polymorphisme obesity eating behavior appetite meals TGR5 receptor dietary preferences polymorphism السمنة سلوك الغذائي الشهية الوجبة مستقبل TGR5التفضيلات الغذائية تعدد الأشكال الجيني Index. décimale : 640 Industrie Alimentaire Résumé :
Our work consists of studying the behavioral determinants of appetite and the involvement of the bile acid receptor TGR5 in the modulation of food preferences and its association with obesity. A survey on eating behavior and assessment of subjective and objective appetite was conducted among 208 young adults. Subjective feelings of appetite were estimated by scores on a visual analog scale and objective appetite was estimated by nutrient intake and interprandial intervals. The identification of a signaling pathway via the TGR5 receptor in lipid-glucidic homeostasis and its implication in the modulation of dietary preferences and in obesity was carried out in WT and TGR5-/- mice. The association of the TGR5 gene polymorphism with obesity has been investigated in 127 children. Food consumption depends on the subjective sensations of appetite, and the preprandial duration. Stress induces overconsumption of energy. Consumption habits and the importance given to meals favored more energy consumption. The subjective satiation score is associated with nutritional intake. The gustatory pleasure score is correlated with protein and lipid intake. Gastric fullness is correlated with fiber intake. The energy density of dishes has a positive influence on satiation and negatively on gastric fullness. Only the sensation of gustatory pleasure is influenced by the pleasantness of the dish served. Postprandial duration is positively correlated with subjective satiation score and gustatory pleasure, but not with gastric fullness.The proteins had presented a satiating effect and a satietogenic power more important, than those of the carbohydrates and the lipids. The deletion of the TGR5 gene associated with a high fat diet, leads to a decrease in energy expenditure, and an imbalance of carbohydrate-lipid and energy homeostasis, as well as a decrease in the secretion of GLP-1. To which are added inflammatory effects and hepatic steatosis. Indeed, TGR5 is also involved in the control of dietary fat intake through its involvement in the physiology of taste buds. The study of the single nucleotide polymorphism of TGR5 (SNP rs11554825) further confirms its involvement in childhood obesity.
Diplôme : Doctorat en sciences En ligne : ../theses/agronomie/BEN7712.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11546 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité BEN/7712 BEN/7712 Thèse Bibliothèque principale Thèses Disponible
Titre : Seuil de détection du goût des lipides et corpulence. Type de document : texte imprimé Auteurs : Ouassila Allam, Auteur ; Hayet Oulamara, Directeur de thèse ; Naim Akhtar Khan, Directeur de thèse Mention d'édition : 30 /09/ 2021 Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2021 Importance : 153 f. Format : 30 cm. Note générale : Doctorat 3éme CYCLE LMD.
1 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
Nutrition, Alimentation et Technologies Agro-AlimentairesTags : Nutrition Humaine: Nutrition Humaine goût lipides sensibilité seuil détection IMC apports obésité polymorphisme taste lipids sensitivity detection threshold BMI nutritional intake obesity polymorphism "
الذوق الدهون الحساسية عتبة الكشف مؤشر كتلة الجسم السمنة تعدد الأشكالIndex. décimale : 640 Industrie Alimentaire Résumé : The main objective of this study is to investigate the relationship between fat detection threshold and weight status of adult women The study included 140 women aged from 18 to 50 years old. Exclusion criterias were considered. Weight and height were measured to calculate BMI. Overweight is defined by a BMI 25 and obesity by a BMI 30. The three alternative forced choice (3-AFC) method has been adapted to determine detection thresholds. Individuals were classified DV K\SRVHQVLWLYH mM and hypersensitive < 3 mM. Lipid perception intensity was measured by a gLMS intensity scale. Nutritional intakes were assessed by a 24 hour foodconsumption diaries repeated 3 times. The level of preference towards fatty foods was assessed by a preference questionnaire. Tongue photography was taken to count fungiform papillae. Two polymorphisms of the CD36 gene were studied (rs1761667 and rs1527483) by real-time PCR. The association of the two polymorphisms with obesity has been investigated in 50 women. Statistical analysis is performed with SPSS software. Our results confirm the association between lipid detection thresholds and weight status of women. The anthropometric parameters (BMI, waist circumference, waist circumference / hip circumference ratio and waist circumference / height ratio) are positively associated with the fat detection threshold. Obese participants are the least sensitive to fat taste. Better sensitivity to oleic acid is associated with better intensity of perception and identification of fat in food. Obese subjects have the lowest lipid perception intensity. Impaired lipid detection is possibly related to overweight in adults. Lipids hyposensitivity has been linked to higher intakes of overall energy and fat intake. It is also linked to higher preference for pure fat and salty-fat foods. Reduced taste density is associated with low taste sensitivity and overweight. Obese
people consume more energy and fat and have a greater preference for fat. The study of polymorphism of the two variants-CD36 gene (rs1761667 and rs1527483) confirms its involvement in obesity in our population.
Note de contenu : Annexes. Diplôme : Doctorat En ligne : ../theses/agronomie/ALL7813.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11645 Seuil de détection du goût des lipides et corpulence. [texte imprimé] / Ouassila Allam, Auteur ; Hayet Oulamara, Directeur de thèse ; Naim Akhtar Khan, Directeur de thèse . - 30 /09/ 2021 . - جامعة الإخوة منتوري قسنطينة, 2021 . - 153 f. ; 30 cm.
Doctorat 3éme CYCLE LMD.
1 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
Nutrition, Alimentation et Technologies Agro-AlimentairesTags : Nutrition Humaine: Nutrition Humaine goût lipides sensibilité seuil détection IMC apports obésité polymorphisme taste lipids sensitivity detection threshold BMI nutritional intake obesity polymorphism "
الذوق الدهون الحساسية عتبة الكشف مؤشر كتلة الجسم السمنة تعدد الأشكالIndex. décimale : 640 Industrie Alimentaire Résumé : The main objective of this study is to investigate the relationship between fat detection threshold and weight status of adult women The study included 140 women aged from 18 to 50 years old. Exclusion criterias were considered. Weight and height were measured to calculate BMI. Overweight is defined by a BMI 25 and obesity by a BMI 30. The three alternative forced choice (3-AFC) method has been adapted to determine detection thresholds. Individuals were classified DV K\SRVHQVLWLYH mM and hypersensitive < 3 mM. Lipid perception intensity was measured by a gLMS intensity scale. Nutritional intakes were assessed by a 24 hour foodconsumption diaries repeated 3 times. The level of preference towards fatty foods was assessed by a preference questionnaire. Tongue photography was taken to count fungiform papillae. Two polymorphisms of the CD36 gene were studied (rs1761667 and rs1527483) by real-time PCR. The association of the two polymorphisms with obesity has been investigated in 50 women. Statistical analysis is performed with SPSS software. Our results confirm the association between lipid detection thresholds and weight status of women. The anthropometric parameters (BMI, waist circumference, waist circumference / hip circumference ratio and waist circumference / height ratio) are positively associated with the fat detection threshold. Obese participants are the least sensitive to fat taste. Better sensitivity to oleic acid is associated with better intensity of perception and identification of fat in food. Obese subjects have the lowest lipid perception intensity. Impaired lipid detection is possibly related to overweight in adults. Lipids hyposensitivity has been linked to higher intakes of overall energy and fat intake. It is also linked to higher preference for pure fat and salty-fat foods. Reduced taste density is associated with low taste sensitivity and overweight. Obese
people consume more energy and fat and have a greater preference for fat. The study of polymorphism of the two variants-CD36 gene (rs1761667 and rs1527483) confirms its involvement in obesity in our population.
Note de contenu : Annexes. Diplôme : Doctorat En ligne : ../theses/agronomie/ALL7813.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11645 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité ALL/7813 ALL/7813 Thèse Bibliothèque principale Thèses Disponible
