Détail de l'auteur
Auteur Toma Nardjes Mouas |
Documents disponibles écrits par cet auteur (4)
Affiner la recherche Interroger des sources externesCriblage des plantes médicinales utilisées dans la région de Constantine-Mila et valorisation phytochimique des plantes / Rayene Ouelbani
Titre : Criblage des plantes médicinales utilisées dans la région de Constantine-Mila et valorisation phytochimique des plantes : Bellevalia mauritanica Pomel ; Endémique de l’Afrique du Nord et Dittrichia viscosa (L.) Greuter. Type de document : texte imprimé Auteurs : Rayene Ouelbani, Auteur ; Douadi Khelifi, Directeur de thèse ; Toma Nardjes Mouas, Directeur de thèse Mention d'édition : 25/10/2021 Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2021 Importance : 174 f. Format : 30 cm. Note générale : Doctorat 3éme CYCLE LMD.
1 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : Biochimie et Biologie Cellulaire et Moléculaire : Biochimie Appliquée Ethnobotanique Bellevalia mauritanica Pomel LC-MS/MS HPLC-MS-ITTOF activités biologiques Ethnobotany biological activities Index. décimale : 570 Sciences de la vie. Biologie Résumé :
The privileged geographical situation of Algeria confers a great floristic richness which represents an asset for phytochemistry, moreover until our days the Algerian population resorts to the traditional practices using plants to cure themselves. The present work is divided into two parts, the first one devoted to an ethnobotanical
investigation on the medicinal plants used in the region of Constantine and Mila and the second one includes the phytochemical study of the endemic North African plant Bellevalia mauritanica Pomel, as well as the evaluation of its biological activities in vitro. The ethnobotanical investigation of the region of Constantine and Mila, allowed us to obtain the following results: out of 102 plants mentioned, 28 new species, 31 common plants with 151 new therapeutic applications, in comparison with other regions in Algeria were mentioned and 12 new species including an endemic plant Zygophyllum cornutum Coss., 75 known plants with 369 new medicinal uses, in comparison with other regions of the Mediterranean basin. The phytochemical study of Bellevalia mauritanica Pomel by liquid chromatography coupled to a hybrid ion trap and time-of-flight mass spectrometer (LC-MS-IT-TOF) indicated the presence of 91 compounds in the different phases of the crude extract of the underground part and a validated method of liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS), using 37 standards revealed the content of phenolic acids rather than flavonoids, in fact the AcOEt phase contains caffeic acid (1240.7 µg/g extract) and the CHCl3 phase contains vanillin (2048.5 µg/g extract) in high amounts, as well as the evaluation of its Antioxidant, anticholinesterase and antibacterial in vitro activities showed that among the tested extracts, the AcOEt phase shows good antioxidant activity, especially in ABTS•+ (2, 2'- azinobis-(3-ethylbenzothiazoline-6-sulfonic), DPPH• (1,1-diphenyl-2-picrylhydrazyl) and DMSO (dimethylsulfoxide) alkaline superoxide anion, considerable inhibition of acetylcholinesterase and moderate antibacterial effect.
Note de contenu : Annexes. Diplôme : Doctorat En ligne : ../theses/biologie/OUE7828.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11660 Criblage des plantes médicinales utilisées dans la région de Constantine-Mila et valorisation phytochimique des plantes : Bellevalia mauritanica Pomel ; Endémique de l’Afrique du Nord et Dittrichia viscosa (L.) Greuter. [texte imprimé] / Rayene Ouelbani, Auteur ; Douadi Khelifi, Directeur de thèse ; Toma Nardjes Mouas, Directeur de thèse . - 25/10/2021 . - جامعة الإخوة منتوري قسنطينة, 2021 . - 174 f. ; 30 cm.
Doctorat 3éme CYCLE LMD.
1 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Biochimie et Biologie Cellulaire et Moléculaire : Biochimie Appliquée Ethnobotanique Bellevalia mauritanica Pomel LC-MS/MS HPLC-MS-ITTOF activités biologiques Ethnobotany biological activities Index. décimale : 570 Sciences de la vie. Biologie Résumé :
The privileged geographical situation of Algeria confers a great floristic richness which represents an asset for phytochemistry, moreover until our days the Algerian population resorts to the traditional practices using plants to cure themselves. The present work is divided into two parts, the first one devoted to an ethnobotanical
investigation on the medicinal plants used in the region of Constantine and Mila and the second one includes the phytochemical study of the endemic North African plant Bellevalia mauritanica Pomel, as well as the evaluation of its biological activities in vitro. The ethnobotanical investigation of the region of Constantine and Mila, allowed us to obtain the following results: out of 102 plants mentioned, 28 new species, 31 common plants with 151 new therapeutic applications, in comparison with other regions in Algeria were mentioned and 12 new species including an endemic plant Zygophyllum cornutum Coss., 75 known plants with 369 new medicinal uses, in comparison with other regions of the Mediterranean basin. The phytochemical study of Bellevalia mauritanica Pomel by liquid chromatography coupled to a hybrid ion trap and time-of-flight mass spectrometer (LC-MS-IT-TOF) indicated the presence of 91 compounds in the different phases of the crude extract of the underground part and a validated method of liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS), using 37 standards revealed the content of phenolic acids rather than flavonoids, in fact the AcOEt phase contains caffeic acid (1240.7 µg/g extract) and the CHCl3 phase contains vanillin (2048.5 µg/g extract) in high amounts, as well as the evaluation of its Antioxidant, anticholinesterase and antibacterial in vitro activities showed that among the tested extracts, the AcOEt phase shows good antioxidant activity, especially in ABTS•+ (2, 2'- azinobis-(3-ethylbenzothiazoline-6-sulfonic), DPPH• (1,1-diphenyl-2-picrylhydrazyl) and DMSO (dimethylsulfoxide) alkaline superoxide anion, considerable inhibition of acetylcholinesterase and moderate antibacterial effect.
Note de contenu : Annexes. Diplôme : Doctorat En ligne : ../theses/biologie/OUE7828.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11660 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité OUE/7828 OUE/7828 Thèse Bibliothèque principale Thèses Disponible
Titre : Etude et valorisation des plantes médicinales algériennes; Contribution à une enquête ethnobotanique et investigations phytochimiques et biologiques sur les deux plantes : Iris unguicularis Poir. et Dittrichia viscosa (L.) Greuter. Type de document : texte imprimé Auteurs : Souheir Bensari, Auteur ; Douadi Khelifi, Directeur de thèse ; Toma Nardjes Mouas, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Importance : 137 f. Format : 30 cm. Note générale : Doctorat 3éme CYCLE LMD.
1 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : Biochimie et Biologie Cellulaire et Moléculaire : Biochimie Appliquée Iris unguicularis Poir. Dittrichia viscosa (L.) Grueter composés phénoliques acide isocostique LC-MS/MS activité antioxydante activité antibacterienne activité cytotoxique phenolic compounds isocostic acid antioxidant activity antibacterial activity cytotoxic activity فعالية مضاد الأكسدة مضاد للبكتيريا النشاط السام للخلايا LC-MS/MSمركبات فينوليه Index. décimale : 570 Sciences de la vie. Biologie Résumé :
The present work aims to the valorization of Algerian flora by phytochemical et biological investigations on two species : Iris unguicularis Poir. and Dittrichia viscosa (L.) Greuter. This study allowed to identify several phytochemical compounds and to record satisfactory results for different biological activities tested for this two species. LC-MS IT-TOF analysis of the different extracts (AI, CI et BI) of Iris unguicularis Poir. species led to the quantification of 70 compounds, while the LC-MS/MS analysis accomplished by a previously validated method by using 37 standards revealed the presence of 17 phenolic compounds and the richest extracts were, AI and CI, AI extract was mainly composed by: 4-OH-benzoic acid (2218.2 µg analyte/g extract), syringinic acid (1218.6 µg analyte/g extract), protocatechuique acid (1080. 4 µg analyte/g extract) and p-coumaric acid (1071.2 µg analyte/g extract), the CI extract was mainly composed by: naringinia (1453.4 µg analyte/g extract) and ferulic acid (1088, 41 µg analyte/g extract). Results showed also the high antioxidant an antibacterial activities of these extracts . Structural elucidation of isocostic acid isolated from the species Dittrichia viscosa (L.) Greuter, was performed by NMR technique (1H and 13C). The results of activities carried out on this compound revealed its apoptotic effect by acting as pro-oxidant which allows to generate the superoxide anion in one hand and on the other hand by its effect on mitochondrial swelling. The viability of cells via MTT assay tested against U118, Caco-2, SKOV-3 and HDF lines showed that isocostic acid had a significant effect on cell proliferation by causing a dose-dependent cytotoxicity especially against U118 line in which proliferation is clearly decreased between 100μg and 200 μg with an IC50 of 72.32 μg/ml.
Note de contenu :
Annexes.
Diplôme : Doctorat En ligne : ../theses/biologie/BEN7829.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11661 Etude et valorisation des plantes médicinales algériennes; Contribution à une enquête ethnobotanique et investigations phytochimiques et biologiques sur les deux plantes : Iris unguicularis Poir. et Dittrichia viscosa (L.) Greuter. [texte imprimé] / Souheir Bensari, Auteur ; Douadi Khelifi, Directeur de thèse ; Toma Nardjes Mouas, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, [s.d.] . - 137 f. ; 30 cm.
Doctorat 3éme CYCLE LMD.
1 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Biochimie et Biologie Cellulaire et Moléculaire : Biochimie Appliquée Iris unguicularis Poir. Dittrichia viscosa (L.) Grueter composés phénoliques acide isocostique LC-MS/MS activité antioxydante activité antibacterienne activité cytotoxique phenolic compounds isocostic acid antioxidant activity antibacterial activity cytotoxic activity فعالية مضاد الأكسدة مضاد للبكتيريا النشاط السام للخلايا LC-MS/MSمركبات فينوليه Index. décimale : 570 Sciences de la vie. Biologie Résumé :
The present work aims to the valorization of Algerian flora by phytochemical et biological investigations on two species : Iris unguicularis Poir. and Dittrichia viscosa (L.) Greuter. This study allowed to identify several phytochemical compounds and to record satisfactory results for different biological activities tested for this two species. LC-MS IT-TOF analysis of the different extracts (AI, CI et BI) of Iris unguicularis Poir. species led to the quantification of 70 compounds, while the LC-MS/MS analysis accomplished by a previously validated method by using 37 standards revealed the presence of 17 phenolic compounds and the richest extracts were, AI and CI, AI extract was mainly composed by: 4-OH-benzoic acid (2218.2 µg analyte/g extract), syringinic acid (1218.6 µg analyte/g extract), protocatechuique acid (1080. 4 µg analyte/g extract) and p-coumaric acid (1071.2 µg analyte/g extract), the CI extract was mainly composed by: naringinia (1453.4 µg analyte/g extract) and ferulic acid (1088, 41 µg analyte/g extract). Results showed also the high antioxidant an antibacterial activities of these extracts . Structural elucidation of isocostic acid isolated from the species Dittrichia viscosa (L.) Greuter, was performed by NMR technique (1H and 13C). The results of activities carried out on this compound revealed its apoptotic effect by acting as pro-oxidant which allows to generate the superoxide anion in one hand and on the other hand by its effect on mitochondrial swelling. The viability of cells via MTT assay tested against U118, Caco-2, SKOV-3 and HDF lines showed that isocostic acid had a significant effect on cell proliferation by causing a dose-dependent cytotoxicity especially against U118 line in which proliferation is clearly decreased between 100μg and 200 μg with an IC50 of 72.32 μg/ml.
Note de contenu :
Annexes.
Diplôme : Doctorat En ligne : ../theses/biologie/BEN7829.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11661 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité BEN/7829 BEN/7829 Thèse Bibliothèque principale Thèses Disponible
Titre : Synthèse et caractérisation par diffraction des rayons X de nouveaux composés à base d'étain (II) et de benzidine Type de document : texte imprimé Auteurs : Toma Nardjes Mouas ; Univ. de Constantine, Éditeur scientifique ; H. Merazig, Directeur de thèse Année de publication : 2008 Importance : 72 f. Note générale : 01 Disponible à la salle de recherche 02 Disponibles au magazin de la B.U.C. 01 CD Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Etain ( II ) Benzidine Index. décimale : 540 Chimie et sciences connexes En ligne : ../theses/chimie/MOU5218.pdf Permalink : index.php?lvl=notice_display&id=3670 Synthèse et caractérisation par diffraction des rayons X de nouveaux composés à base d'étain (II) et de benzidine [texte imprimé] / Toma Nardjes Mouas ; Univ. de Constantine, Éditeur scientifique ; H. Merazig, Directeur de thèse . - 2008 . - 72 f.
01 Disponible à la salle de recherche 02 Disponibles au magazin de la B.U.C. 01 CD
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Etain ( II ) Benzidine Index. décimale : 540 Chimie et sciences connexes En ligne : ../theses/chimie/MOU5218.pdf Permalink : index.php?lvl=notice_display&id=3670 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité MOU/5218 MOU/5218 Thèse Bibliothèque principale Thèses Disponible 
Titre : Synthèse, caractérisation structurale et propriétés catalytiques de nouveaux composés ferrocéniques Type de document : texte imprimé Auteurs : Toma Nardjes Mouas, Auteur ; Hocine Merazig, Directeur de thèse Editeur : constantine [Algérie] : Université Constantine 1 Année de publication : 2013 Importance : 277 f. Format : 30 cm Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : chiralité ferrocéne hydrazone thiophosphine complexes de Pd(II) caractérisation structurale catalyse chirality ferrocénes hydrazonel Pd(II) complexes structural characterization catalysis لاتناظرية المركبات الحديدية الهيدرازون دراسة البنيوية للمادة التفاعلات المحفزة اللاتناظرية
معقداتPdllIndex. décimale : 540 Chimie et sciences connexes Résumé : Sins the synthesis of novel chiral ligands used as catalysts increased much interest in organometallic chemistry, we decided to develop a new class of thiophosphino ferrocenyl hydrazone and dithionophosphine ligands with planar chirality in order to improve existing reactions as well as inventing new ones in asymmetric synthesis area. In this context, ligands were obtained following defined synthetic pathways, with NMR (1H, 13C, 31P) preliminary characterization of intermediate products at every step in addition to masse higt resolution spectroscopy ESI+ and X ray diffraction on monocristal for our target ligands. Pd(II) Complexes were obtained, by direct mettalation. Pd(II) Complexes have been characterized by NMR spectroscopy and X ray diffraction on monocristal and their coordination chemistry studied. Finally, we carry out some preliminary catalytic tests in Suzuki-Miyaura cross-coupling reaction with the obtained ligands complexes and as a prolongation to our work, we project to do more catalytic investigations. Diplôme : Doctorat en sciences En ligne : ../theses/chimie/MOU6417.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=9444 Synthèse, caractérisation structurale et propriétés catalytiques de nouveaux composés ferrocéniques [texte imprimé] / Toma Nardjes Mouas, Auteur ; Hocine Merazig, Directeur de thèse . - constantine [Algérie] : Université Constantine 1, 2013 . - 277 f. ; 30 cm.
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : chiralité ferrocéne hydrazone thiophosphine complexes de Pd(II) caractérisation structurale catalyse chirality ferrocénes hydrazonel Pd(II) complexes structural characterization catalysis لاتناظرية المركبات الحديدية الهيدرازون دراسة البنيوية للمادة التفاعلات المحفزة اللاتناظرية
معقداتPdllIndex. décimale : 540 Chimie et sciences connexes Résumé : Sins the synthesis of novel chiral ligands used as catalysts increased much interest in organometallic chemistry, we decided to develop a new class of thiophosphino ferrocenyl hydrazone and dithionophosphine ligands with planar chirality in order to improve existing reactions as well as inventing new ones in asymmetric synthesis area. In this context, ligands were obtained following defined synthetic pathways, with NMR (1H, 13C, 31P) preliminary characterization of intermediate products at every step in addition to masse higt resolution spectroscopy ESI+ and X ray diffraction on monocristal for our target ligands. Pd(II) Complexes were obtained, by direct mettalation. Pd(II) Complexes have been characterized by NMR spectroscopy and X ray diffraction on monocristal and their coordination chemistry studied. Finally, we carry out some preliminary catalytic tests in Suzuki-Miyaura cross-coupling reaction with the obtained ligands complexes and as a prolongation to our work, we project to do more catalytic investigations. Diplôme : Doctorat en sciences En ligne : ../theses/chimie/MOU6417.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=9444 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité MOU/6417 MOU/6417 Thèse Bibliothèque principale Thèses Disponible Documents numériques
texte intégraleAdobe Acrobat PDF
