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Auteur Abdellatif Bensegueni |
Documents disponibles écrits par cet auteur (4)
Affiner la recherche Interroger des sources externesConception in silico de nouveaux inhibiteurs de la topoisomérase I de cellules cancéreuses. / Soumia Teniou
Titre : Conception in silico de nouveaux inhibiteurs de la topoisomérase I de cellules cancéreuses. Type de document : texte imprimé Auteurs : Soumia Teniou, Auteur ; Abdellatif Bensegueni, Directeur de thèse Editeur : Constantine : Université Mentouri Constantine Année de publication : 2012 Importance : 95 f. Format : 31 cm. Note générale : 2 copies imprimées disponibles Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : Biochimie:Technologie des Explorations Biochimiques L'ADN Topoisomérase I Flavonoides Modélisation moléculaire Docking moléculaire Surflex Affinité Myricétine DNA topoisomérase I Flavonoids Molecular modeling Molecular Docking Affinity Myricetin الفلافونويدات النمذجة الجزيئية الجاذبية Index. décimale : 570 Sciences de la vie. Biologie Résumé :
Human DNA Topoisomérase I (topo I) is the target of several drugs commonly used in cancer chemotherapy. These drugs induce topo-DNA complexes that eventually trigger cell death. Several flavonoides have been shown as inhibitors of topo I, having an anticancer activity. Using the methods of molecular modeling in particularl the docking by the Surflex program, we theoretically evaluated the affinity of four flavonoids: myricetin, fisetin, quercetin and apigenin, presented in recent studies as inhibitors of topo I. Myricetin with the lowest IC50 (11.1 ± 2.0 µM) gave the best affinity (7.01 M-1). For the development in silico of novel molecules most powerful myricetin, we have made several substitutions. Replacing the hydroxyl group carried by the carbone C3´ of the myricetin by an alcoholic group CH2OH significantly improves the affinity increases from 7.01 M-1 to 8.79 M-1. The application of the rule of Lipinski informs in a positive way about the ADME properties of this new molecule that is as an inhibitor potentially more active than myricetin.Note de contenu : Annexes. Diplôme : Magistère En ligne : ../theses/biologie/TEN6172.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=6108 Conception in silico de nouveaux inhibiteurs de la topoisomérase I de cellules cancéreuses. [texte imprimé] / Soumia Teniou, Auteur ; Abdellatif Bensegueni, Directeur de thèse . - Constantine : Université Mentouri Constantine, 2012 . - 95 f. ; 31 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Biochimie:Technologie des Explorations Biochimiques L'ADN Topoisomérase I Flavonoides Modélisation moléculaire Docking moléculaire Surflex Affinité Myricétine DNA topoisomérase I Flavonoids Molecular modeling Molecular Docking Affinity Myricetin الفلافونويدات النمذجة الجزيئية الجاذبية Index. décimale : 570 Sciences de la vie. Biologie Résumé :
Human DNA Topoisomérase I (topo I) is the target of several drugs commonly used in cancer chemotherapy. These drugs induce topo-DNA complexes that eventually trigger cell death. Several flavonoides have been shown as inhibitors of topo I, having an anticancer activity. Using the methods of molecular modeling in particularl the docking by the Surflex program, we theoretically evaluated the affinity of four flavonoids: myricetin, fisetin, quercetin and apigenin, presented in recent studies as inhibitors of topo I. Myricetin with the lowest IC50 (11.1 ± 2.0 µM) gave the best affinity (7.01 M-1). For the development in silico of novel molecules most powerful myricetin, we have made several substitutions. Replacing the hydroxyl group carried by the carbone C3´ of the myricetin by an alcoholic group CH2OH significantly improves the affinity increases from 7.01 M-1 to 8.79 M-1. The application of the rule of Lipinski informs in a positive way about the ADME properties of this new molecule that is as an inhibitor potentially more active than myricetin.Note de contenu : Annexes. Diplôme : Magistère En ligne : ../theses/biologie/TEN6172.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=6108 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité TEN/6172 TEN/6172 Thèse Bibliothèque principale Thèses Disponible
Titre : Contribution à l’amélioration de l’activité biologique des inhibiteurs de la dipeptidyl-peptidase 4 dans le diabète de type 2 par simulation informatique. Type de document : texte imprimé Auteurs : El-Hassen Mokrani, Auteur ; Abdellatif Bensegueni, Directeur de thèse Editeur : Constantine : Université Mentouri Constantine Année de publication : 2012 Importance : 102 f. Format : 31 cm. Note générale : 2 copies imprimées disponibles Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : Biochimie:Technologie des explorations biochimiques AutoDock Dipeptidyl-peptidase 4 Docking moléculaire Inhibiteur Energie d’interaction Binding energy Molecular docking inhibitor أنزيم DDP4 طاقة الارتباط مثبط Index. décimale : 570 Sciences de la vie. Biologie Résumé : Type 2 diabetes mellitus (T2DM) is a severe and increasingly prevalent disease that is considered as a major global public health. It engenders about four millions death in the world.In our research, we focus on type 2 diabetes treatments based on inhibition of Dipeptidyl-peptidase 4 (DPP4). This enzyme cleaves the incritin hormones which help organism to regulate glycemia only in the case of hyperglycemia. The molecular modeling program: AutoDock, is used to develop in silico new potent DPP4 inhibitors. By poly-substitution of the inhibitor 356 in complex with DPP4 (PDB accession code:2RGU), the binding energy was increased from -11.13Kcal/Mol to -15.13 Kcal/Mol, by the introduction of NH2 on carbon 26, methyl on carbon 34 and finally, the replacement of methyl 14 by CH2CH2NH3+. The application of Lipinski rule informs us in a positive way about ADME/Tox properties of this compound that is considered as a potent DPP4 inhibitor. Note de contenu : Annexes. Diplôme : Magistère En ligne : ../theses/biologie/MOK6107.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=6032 Contribution à l’amélioration de l’activité biologique des inhibiteurs de la dipeptidyl-peptidase 4 dans le diabète de type 2 par simulation informatique. [texte imprimé] / El-Hassen Mokrani, Auteur ; Abdellatif Bensegueni, Directeur de thèse . - Constantine : Université Mentouri Constantine, 2012 . - 102 f. ; 31 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Biochimie:Technologie des explorations biochimiques AutoDock Dipeptidyl-peptidase 4 Docking moléculaire Inhibiteur Energie d’interaction Binding energy Molecular docking inhibitor أنزيم DDP4 طاقة الارتباط مثبط Index. décimale : 570 Sciences de la vie. Biologie Résumé : Type 2 diabetes mellitus (T2DM) is a severe and increasingly prevalent disease that is considered as a major global public health. It engenders about four millions death in the world.In our research, we focus on type 2 diabetes treatments based on inhibition of Dipeptidyl-peptidase 4 (DPP4). This enzyme cleaves the incritin hormones which help organism to regulate glycemia only in the case of hyperglycemia. The molecular modeling program: AutoDock, is used to develop in silico new potent DPP4 inhibitors. By poly-substitution of the inhibitor 356 in complex with DPP4 (PDB accession code:2RGU), the binding energy was increased from -11.13Kcal/Mol to -15.13 Kcal/Mol, by the introduction of NH2 on carbon 26, methyl on carbon 34 and finally, the replacement of methyl 14 by CH2CH2NH3+. The application of Lipinski rule informs us in a positive way about ADME/Tox properties of this compound that is considered as a potent DPP4 inhibitor. Note de contenu : Annexes. Diplôme : Magistère En ligne : ../theses/biologie/MOK6107.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=6032 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité MOK/6107 MOK/6107 Thèse Bibliothèque principale Thèses Disponible
Titre : Effets cicatrisants de produits à base d’huile de lentisque (Pistacia lentiscus L.) sur les brûlures expérimentales chez le rat Type de document : texte imprimé Auteurs : Mohamad Cherif Abdeldjelil, Auteur ; Abdellatif Bensegueni, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2016 Importance : 191 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
PhysiqueTags : Pharmacologie Pistacia lentiscus huile fixe enquête ethnopharmacologique brûlures expérimentales rats effet cicatrisant effet antibactérien fixed oil ethnopharmacological survey experimental burns healing effect antibacterial effect شجرة المصطكي ) (Pistacia lentiscus Lزیت ثابت استقصاء حول الاستعمالات الطبیة
التقلیدیة الحروق التجریبیة الجرذان التئام الحروق ، تأثیر مضاد للجراثیمIndex. décimale : 530 Physique Résumé : Despite the existence of numerous products used for burns’ treatment, the use of traditional medicine remedies remains a common treatment option.
Our ethnopharmacological survey among 104 herbalists and traditional healers spread over 47 municipalities belonging to 19 provinces of the country, revealed the richness of Algerian traditional pharmacopoeia with burn treating products. A total of 74 natural products were identified.
Ranking these products by calculating their Relative Popularity Level (RPL) revealed that the fixed oil extracted from the fruits of mastic tree (Pistacia lentiscus L.) is the most used natural product for burn treatment.
Furthermore, unlike the majority of Mediterranean pharmacopeia, this oil is the most used product of Pistacia lentiscus in Algeria, surpassing the use of leaves, resin and essential oils.
Our survey concerning the therapeutic uses of this oil revealed its use for 50 various therapeutic indications. Ranking these indications by calculating their Fidelity Level (FL) revealed that the treatment of skin and respiratory problems are the two major indications of Pistacia lentiscus fixed oil in Algeria.
The healing effect of this oil, used alone or mixed with beeswax (v/v) was evaluated for the treatment of experimental burns in rats. The healing process was evaluated by digital planimetry and histological examination of burned skin samples.
Mastic fixed oil used alone or in combination with beeswax, showed significantly better results (p˂0,05) than conventional treatment with silver sulfadiazine 1%. This healing effect resulted in an acceleration of wound contraction and a reduction of epithelialization time.
Histological observations corroborate with the clinical and planimetric findings.
No Synergistic or antagonistic effects were found between mastic oil and beeswax.
The in vitro investigation of the antibacterial effect of this oil on four bacterial strains (Staphylococcus aureus ; Enterococcus faecalis ; Escherichia coli ; Pseudomonas aeruginosa) showed no significant antibacterial effect. Hence the need to undertake further studies to identify the mechanisms responsible for the healing effect of this oil and the bioactive compounds behind it.Diplôme : Doctorat en sciences En ligne : ../theses/veterinaire/ABD6908.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10243 Effets cicatrisants de produits à base d’huile de lentisque (Pistacia lentiscus L.) sur les brûlures expérimentales chez le rat [texte imprimé] / Mohamad Cherif Abdeldjelil, Auteur ; Abdellatif Bensegueni, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2016 . - 191 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
PhysiqueTags : Pharmacologie Pistacia lentiscus huile fixe enquête ethnopharmacologique brûlures expérimentales rats effet cicatrisant effet antibactérien fixed oil ethnopharmacological survey experimental burns healing effect antibacterial effect شجرة المصطكي ) (Pistacia lentiscus Lزیت ثابت استقصاء حول الاستعمالات الطبیة
التقلیدیة الحروق التجریبیة الجرذان التئام الحروق ، تأثیر مضاد للجراثیمIndex. décimale : 530 Physique Résumé : Despite the existence of numerous products used for burns’ treatment, the use of traditional medicine remedies remains a common treatment option.
Our ethnopharmacological survey among 104 herbalists and traditional healers spread over 47 municipalities belonging to 19 provinces of the country, revealed the richness of Algerian traditional pharmacopoeia with burn treating products. A total of 74 natural products were identified.
Ranking these products by calculating their Relative Popularity Level (RPL) revealed that the fixed oil extracted from the fruits of mastic tree (Pistacia lentiscus L.) is the most used natural product for burn treatment.
Furthermore, unlike the majority of Mediterranean pharmacopeia, this oil is the most used product of Pistacia lentiscus in Algeria, surpassing the use of leaves, resin and essential oils.
Our survey concerning the therapeutic uses of this oil revealed its use for 50 various therapeutic indications. Ranking these indications by calculating their Fidelity Level (FL) revealed that the treatment of skin and respiratory problems are the two major indications of Pistacia lentiscus fixed oil in Algeria.
The healing effect of this oil, used alone or mixed with beeswax (v/v) was evaluated for the treatment of experimental burns in rats. The healing process was evaluated by digital planimetry and histological examination of burned skin samples.
Mastic fixed oil used alone or in combination with beeswax, showed significantly better results (p˂0,05) than conventional treatment with silver sulfadiazine 1%. This healing effect resulted in an acceleration of wound contraction and a reduction of epithelialization time.
Histological observations corroborate with the clinical and planimetric findings.
No Synergistic or antagonistic effects were found between mastic oil and beeswax.
The in vitro investigation of the antibacterial effect of this oil on four bacterial strains (Staphylococcus aureus ; Enterococcus faecalis ; Escherichia coli ; Pseudomonas aeruginosa) showed no significant antibacterial effect. Hence the need to undertake further studies to identify the mechanisms responsible for the healing effect of this oil and the bioactive compounds behind it.Diplôme : Doctorat en sciences En ligne : ../theses/veterinaire/ABD6908.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10243 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité ABD/6908 ABD/6908 Thèse Bibliothèque principale Thèses Disponible
Titre : Etude structurale par diffraction des rayons X et établissement des graphes du modèle des liaisons Hydrogène de nouveaux composés hybrides Type de document : texte imprimé Auteurs : Abdellatif Bensegueni ; Univ. de Constantine, Éditeur scientifique ; A. Cherouana, Directeur de thèse Année de publication : 2007 Importance : 87 f. Note générale : 01 Disponible à la salle de recherche 02 Disponibles au magazin de la B.U.C. 01 CD Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : diffraction des rayons X Liaisons hydrogène Composés hybrides Graphes Index. décimale : 540 Chimie et sciences connexes En ligne : ../theses/chimie/BEN4881.pdf Permalink : index.php?lvl=notice_display&id=3751 Etude structurale par diffraction des rayons X et établissement des graphes du modèle des liaisons Hydrogène de nouveaux composés hybrides [texte imprimé] / Abdellatif Bensegueni ; Univ. de Constantine, Éditeur scientifique ; A. Cherouana, Directeur de thèse . - 2007 . - 87 f.
01 Disponible à la salle de recherche 02 Disponibles au magazin de la B.U.C. 01 CD
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : diffraction des rayons X Liaisons hydrogène Composés hybrides Graphes Index. décimale : 540 Chimie et sciences connexes En ligne : ../theses/chimie/BEN4881.pdf Permalink : index.php?lvl=notice_display&id=3751 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité BEN/4881 BEN/4881 Thèse Bibliothèque principale Thèses Disponible
