Titre :	Etude phytochimique et pharmacologique d’espèces de deux familles Lamiacées et Apiacées Salvia phlomoides Asso. et Ferula vesceritensis Coss. et Dur.
Type de document :	texte imprimé
Auteurs :	Lamia Benniou ép Gherbi, Auteur ; Samir Benayache, Directeur de thèse ; Fadila Benayache, Directeur de thèse
Editeur :	جامعة الإخوة منتوري قسنطينة
Année de publication :	2018
Importance :	185 f.
Format :	30 cm.
Note générale :	Doctorat 3éme CYCLE LMD. 2 copies imprimées disponibles
Langues :	Français (fre)
Catégories :	Français - Anglais Chimie
Tags :	Chimie pharmaceutique: Analyses physicochimiques, contrôle de la qualité et synthèse de substances bioactives  Lamiacées  Salvia phlomoides  triterpènes  oléananes  cytotoxicité  Apaiacées  Ferula vesceritensis  flavonoides  activité antioxydante  Lamiaceae  oleanane triterpenoids  cytotoxicity screening  Apaiaceae  flavonoids  antioxidant activity  تريتربين  سمية خلوية  فلافونويد  مضاد الاكسدة
Index. décimale :	540 Chimie et sciences connexes
Résumé :	This work deals with phytochemical and pharmacological study of two species Salvia phlomoides Asso. from Lamiaceae family and Ferula vesceritensis Coss. Et Dur. from the Apiaceae family.The separation and purification by chromatographical methods of chloroform and ethyl acetate extract of Salvia phlomoides led to the isolation of nine compounds including four triterpenoids from which three are new, four flavonoids, one phenolic acid, and three flavonoids from the ethyl acetate extract of Ferula vesceritensis. The structural etermination of the isolated compounds was established on the basis of spectral analysis IR; ESI-HR-MS, 1D and 2D NMR (1H NMR, 13C NMR, DEPT-135, HSQC, HMBC, COSY and NOESY), and comparison with literature data. Evaluation of the cytotoxicity of the new triterpenoids showed a selective inhibitory effect against the panel of human tumor cell lines NCI-60 of the National Cancer Institute of the United States of America. Evaluation of the antioxidant activity by different methods of the ethyl acetate and n-butanol extracts of Salvia phlomoides and ethyl acetate extract of Ferula vesceritensis indicates an important antioxidant capacity. The GC and GC-MS analysis of the essential oils of the two species showed that the essential oil of Salvia phlomoides (studied for the first time) was mainly represented by Hexahydrofarnesyl acetone, Dibutyle phtalate, Phytol, α-Humulene, Caryophyllene Oxyde and β-Caryophyllene, and major components of the essential oil of Ferula vesceritensis (South) were Shyobunol, δ-Cadinene, ϒ-Cadinene, Isoledene and Dauca-5,8-diene, while for Ferula vesceritensis (East), D-Carvone and Rotundifolone were found as major components for the first time in the genus Ferula.
Note de contenu :	Annexes.
Diplôme :	Doctorat
En ligne :	../theses/chimie/BEN7421.pdf
Format de la ressource électronique :	pdf
Permalink :	index.php?lvl=notice_display&id=11074

Etude phytochimique et pharmacologique d’espèces de deux familles Lamiacées et Apiacées Salvia phlomoides Asso. et Ferula vesceritensis Coss. et Dur. [texte imprimé] / Lamia Benniou ép Gherbi, Auteur ; Samir Benayache, Directeur de thèse ; Fadila Benayache, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2018 . - 185 f. ; 30 cm.
Doctorat 3éme CYCLE LMD.
2 copies imprimées disponibles

Langues : Français (fre)

Catégories :	Français - Anglais Chimie
Tags :	Chimie pharmaceutique: Analyses physicochimiques, contrôle de la qualité et synthèse de substances bioactives  Lamiacées  Salvia phlomoides  triterpènes  oléananes  cytotoxicité  Apaiacées  Ferula vesceritensis  flavonoides  activité antioxydante  Lamiaceae  oleanane triterpenoids  cytotoxicity screening  Apaiaceae  flavonoids  antioxidant activity  تريتربين  سمية خلوية  فلافونويد  مضاد الاكسدة
Index. décimale :	540 Chimie et sciences connexes
Résumé :	This work deals with phytochemical and pharmacological study of two species Salvia phlomoides Asso. from Lamiaceae family and Ferula vesceritensis Coss. Et Dur. from the Apiaceae family.The separation and purification by chromatographical methods of chloroform and ethyl acetate extract of Salvia phlomoides led to the isolation of nine compounds including four triterpenoids from which three are new, four flavonoids, one phenolic acid, and three flavonoids from the ethyl acetate extract of Ferula vesceritensis. The structural etermination of the isolated compounds was established on the basis of spectral analysis IR; ESI-HR-MS, 1D and 2D NMR (1H NMR, 13C NMR, DEPT-135, HSQC, HMBC, COSY and NOESY), and comparison with literature data. Evaluation of the cytotoxicity of the new triterpenoids showed a selective inhibitory effect against the panel of human tumor cell lines NCI-60 of the National Cancer Institute of the United States of America. Evaluation of the antioxidant activity by different methods of the ethyl acetate and n-butanol extracts of Salvia phlomoides and ethyl acetate extract of Ferula vesceritensis indicates an important antioxidant capacity. The GC and GC-MS analysis of the essential oils of the two species showed that the essential oil of Salvia phlomoides (studied for the first time) was mainly represented by Hexahydrofarnesyl acetone, Dibutyle phtalate, Phytol, α-Humulene, Caryophyllene Oxyde and β-Caryophyllene, and major components of the essential oil of Ferula vesceritensis (South) were Shyobunol, δ-Cadinene, ϒ-Cadinene, Isoledene and Dauca-5,8-diene, while for Ferula vesceritensis (East), D-Carvone and Rotundifolone were found as major components for the first time in the genus Ferula.
Note de contenu :	Annexes.
Diplôme :	Doctorat
En ligne :	../theses/chimie/BEN7421.pdf
Format de la ressource électronique :	pdf
Permalink :	index.php?lvl=notice_display&id=11074