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Auteur Djalila Rezgoune-Chellat |
Documents disponibles écrits par cet auteur (4)
Affiner la recherche Interroger des sources externesAnalyse cytogénétique des anomalies chromosomatiques des hommes infertiles / Djalila Rezgoune-Chellat
Titre : Analyse cytogénétique des anomalies chromosomatiques des hommes infertiles Type de document : texte imprimé Auteurs : Djalila Rezgoune-Chellat, Auteur ; Univ. de Constantine, Éditeur scientifique ; D. Satta, Directeur de thèse Année de publication : 2007 Importance : 97 f. Note générale : 01 Disponible à la salle de recherche 02 Disponibles au magazin de la B.U.C. 01 CD Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : Male Infertilité Etude cytogénétique Index. décimale : 570 Sciences de la vie. Biologie Diplôme : Magistère En ligne : ../theses/biologie/REZ4877.pdf Permalink : index.php?lvl=notice_display&id=1755 Analyse cytogénétique des anomalies chromosomatiques des hommes infertiles [texte imprimé] / Djalila Rezgoune-Chellat, Auteur ; Univ. de Constantine, Éditeur scientifique ; D. Satta, Directeur de thèse . - 2007 . - 97 f.
01 Disponible à la salle de recherche 02 Disponibles au magazin de la B.U.C. 01 CD
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Male Infertilité Etude cytogénétique Index. décimale : 570 Sciences de la vie. Biologie Diplôme : Magistère En ligne : ../theses/biologie/REZ4877.pdf Permalink : index.php?lvl=notice_display&id=1755 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité REZ/4877 REZ/4877 Thèse Bibliothèque principale Thèses Disponible
Titre : Cancer de la prostate : gènes de susceptibilité et marqueurs génétiques. Type de document : texte imprimé Auteurs : Samah Tellouche ép Bouhouhou, Auteur ; Djalila Rezgoune-Chellat, Directeur de thèse ; Abderezzak Dahdouh, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2019 Importance : 130 f. Format : 30 cm. Note générale : Doctorat 3éme CYCLE.
2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : Biologie Animale:Génétique Moléculaire cancer de la prostate anatomopathologie polymorphisme MTHFR XRCC4 PCR/RFLP Prostate cancer Anatomopathology Polymorphism سرطان البروستاتا التشريح المرضي للأنسجة التعدد الأليلي PCR Index. décimale : 570 Sciences de la vie. Biologie Résumé : Prostate cancer is one of the most common malignant cancers among men. Age,ethnicity and family history are the established risk factors. The objective of this study was to realize a clinical-pathological study and to examine through molecular analysis of the possible combination between MTHFR C677T and XRCC4 G-1394T polymorphisms with the risk of prostate cancer among Algerian men. Methods: This case control study was conducted on 120 patients with prostate cancer and 101 controls. Clinical-pathological study was conducted using a questionnaire and consulting medical records. Anatomo-pathological study has been carried out by exploring surgical specimens. With regard to molecular analysis, genomic DNA was extracted by NaCl method and identification of polymorphisms in the MTHFR and XRCC4 genes for patients and controls has been carried out by using PCR-RFLP technique. Results: In Algeria, prostate cancer affects men at age the 50 and more. We found that the risk of this cancer increases significantly among alcoholics. 20,83% of patients with a family history of prostate cancer and 47,49% with other pathologies (Hypertention, Diabetes 1 and 2, heart disease). 75% of patients have abnormal RT at diagnosis. More than half of patients (58,33%) with PSA levels above 50 ng/ml. According to Gleason score, there are as many moderately differentiated adenocarcinoma as little or no differentiated adenocarcinoma. 64,16% of patients at a late stage and distant metastasis, underlining delayed diagnosis in our country. For the MTHFR C677T polymorphism, we found that the heterozygotes 677CT could be a risk factor for prostate cancer (p = 0,04; OR= 2,01, 95% IC: 1,02- 3,95). However, no association was observed between XRCC4 G-1394T polymorphism and the risk of prostate cancer (p = 0,26; OR= 0,52, 95% IC: 0,17-1,49). Conclusion: Our results seem to indicate that the risk of prostate cancer increase with alcohol consumption. In addition, genes polymorphisms could play a role in prostate carcinogenesis underscoring the importance of genetic screening. Note de contenu : Annexes. Diplôme : Doctorat En ligne : ../theses/biologie/TEL7479.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11311 Cancer de la prostate : gènes de susceptibilité et marqueurs génétiques. [texte imprimé] / Samah Tellouche ép Bouhouhou, Auteur ; Djalila Rezgoune-Chellat, Directeur de thèse ; Abderezzak Dahdouh, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2019 . - 130 f. ; 30 cm.
Doctorat 3éme CYCLE.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Biologie Animale:Génétique Moléculaire cancer de la prostate anatomopathologie polymorphisme MTHFR XRCC4 PCR/RFLP Prostate cancer Anatomopathology Polymorphism سرطان البروستاتا التشريح المرضي للأنسجة التعدد الأليلي PCR Index. décimale : 570 Sciences de la vie. Biologie Résumé : Prostate cancer is one of the most common malignant cancers among men. Age,ethnicity and family history are the established risk factors. The objective of this study was to realize a clinical-pathological study and to examine through molecular analysis of the possible combination between MTHFR C677T and XRCC4 G-1394T polymorphisms with the risk of prostate cancer among Algerian men. Methods: This case control study was conducted on 120 patients with prostate cancer and 101 controls. Clinical-pathological study was conducted using a questionnaire and consulting medical records. Anatomo-pathological study has been carried out by exploring surgical specimens. With regard to molecular analysis, genomic DNA was extracted by NaCl method and identification of polymorphisms in the MTHFR and XRCC4 genes for patients and controls has been carried out by using PCR-RFLP technique. Results: In Algeria, prostate cancer affects men at age the 50 and more. We found that the risk of this cancer increases significantly among alcoholics. 20,83% of patients with a family history of prostate cancer and 47,49% with other pathologies (Hypertention, Diabetes 1 and 2, heart disease). 75% of patients have abnormal RT at diagnosis. More than half of patients (58,33%) with PSA levels above 50 ng/ml. According to Gleason score, there are as many moderately differentiated adenocarcinoma as little or no differentiated adenocarcinoma. 64,16% of patients at a late stage and distant metastasis, underlining delayed diagnosis in our country. For the MTHFR C677T polymorphism, we found that the heterozygotes 677CT could be a risk factor for prostate cancer (p = 0,04; OR= 2,01, 95% IC: 1,02- 3,95). However, no association was observed between XRCC4 G-1394T polymorphism and the risk of prostate cancer (p = 0,26; OR= 0,52, 95% IC: 0,17-1,49). Conclusion: Our results seem to indicate that the risk of prostate cancer increase with alcohol consumption. In addition, genes polymorphisms could play a role in prostate carcinogenesis underscoring the importance of genetic screening. Note de contenu : Annexes. Diplôme : Doctorat En ligne : ../theses/biologie/TEL7479.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11311 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité TEL/7479 TEL/7479 Thèse Bibliothèque principale Thèses Disponible
Titre : Étude cytogénétique et moléculaire des infertilités masculines Type de document : texte imprimé Auteurs : Djalila Rezgoune-Chellat, Auteur ; D. Satta, Directeur de thèse Editeur : Constantine : Université Mentouri Constantine Année de publication : 2013 Importance : 100 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : Infertilité masculine, Anomalies chromosomiques, Microdélétion AZF, MTHFR, NR5A1 Index. décimale : 570 Sciences de la vie. Biologie Diplôme : Doctorat en sciences En ligne : ../theses/biologie/REZ6384.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=9395 Étude cytogénétique et moléculaire des infertilités masculines [texte imprimé] / Djalila Rezgoune-Chellat, Auteur ; D. Satta, Directeur de thèse . - Constantine : Université Mentouri Constantine, 2013 . - 100 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Infertilité masculine, Anomalies chromosomiques, Microdélétion AZF, MTHFR, NR5A1 Index. décimale : 570 Sciences de la vie. Biologie Diplôme : Doctorat en sciences En ligne : ../theses/biologie/REZ6384.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=9395 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité REZ/6384 REZ/6384 Thèse Bibliothèque principale Thèses Disponible Documents numériques
REZ6384.pdfAdobe Acrobat PDF
Titre : Gènes de prédisposition au cancer prostatique. Type de document : texte imprimé Auteurs : Somia Medjani, Auteur ; Djalila Rezgoune-Chellat, Directeur de thèse Mention d'édition : 24/10/2019 Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2019 Importance : 145 f. Format : 30 cm. Note générale : Doctorat 3éme CYCLE LMD.
1 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : Biologie Animale:Génétique Moléculaire cancer de la prostate facteurs de risque polymorphisme CYP1A1 T3801C GSTM1 GSTT1 VEGF -2578C/A PCR/RFLP PCR multiplexe prostate cancer risk factors polymorphism multiplex PCR سرطان البروستاتا عوامل الخطر التعدد الأليلي GSTT1
multiplexe PCR. VEGIndex. décimale : 570 Sciences de la vie. Biologie Résumé : Prostate cancer is currently the most frequently diagnosed cancer and is the leading cause of death in men. In this sense, the objective of our work was to identify, through two statistical studies, some risk factors and histopathological parameters, as well as the possible involvement of genes encoding detoxification enzymes (CYP1A1, GSTM1 and GSTT1) and gene encoding a factor of angiogenesis (-2587C/A of VEGF) and the occurrence of prostate cancer after molecular analysis using the PCR/RFLP technique and multiplex PCR. The statistical study demonstrated an increase in the rate of prostate cancer from the age 60 years old with means age of 71.66±7.99. On the other hand, the presence of family history, smoking and occupational exposure (truck driver, builder, painter, farmer….) are recorded as risk factors implicated in this cancer. Also the sporadic form is the most common form in prostates cancers. Furthermore, the most prostate cancer are adenocarcinoma at the prostatic capsule (PSA >10 ng/ml ; Gleason Score8 ≤ GS ≤ 10). Finally, the genetic analysis of patients and controls for the studied genes presented by the pvalue indicates that no association between the deletion of GSTM1 and the CYP1A1 3801T>C variant and prostate carcinogenesis. However, the deletion of GSTT1 and the double deletion of GSTM1/GSTT1 are involved in the development of prostate cancer. Thus the results of the VEGF-2578C/A variant show a significant difference with susceptibility to prostate cancer. Note de contenu : Annexes. Diplôme : Doctorat En ligne : ../theses/biologie/MED7571.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11409 Gènes de prédisposition au cancer prostatique. [texte imprimé] / Somia Medjani, Auteur ; Djalila Rezgoune-Chellat, Directeur de thèse . - 24/10/2019 . - جامعة الإخوة منتوري قسنطينة, 2019 . - 145 f. ; 30 cm.
Doctorat 3éme CYCLE LMD.
1 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Biologie Animale:Génétique Moléculaire cancer de la prostate facteurs de risque polymorphisme CYP1A1 T3801C GSTM1 GSTT1 VEGF -2578C/A PCR/RFLP PCR multiplexe prostate cancer risk factors polymorphism multiplex PCR سرطان البروستاتا عوامل الخطر التعدد الأليلي GSTT1
multiplexe PCR. VEGIndex. décimale : 570 Sciences de la vie. Biologie Résumé : Prostate cancer is currently the most frequently diagnosed cancer and is the leading cause of death in men. In this sense, the objective of our work was to identify, through two statistical studies, some risk factors and histopathological parameters, as well as the possible involvement of genes encoding detoxification enzymes (CYP1A1, GSTM1 and GSTT1) and gene encoding a factor of angiogenesis (-2587C/A of VEGF) and the occurrence of prostate cancer after molecular analysis using the PCR/RFLP technique and multiplex PCR. The statistical study demonstrated an increase in the rate of prostate cancer from the age 60 years old with means age of 71.66±7.99. On the other hand, the presence of family history, smoking and occupational exposure (truck driver, builder, painter, farmer….) are recorded as risk factors implicated in this cancer. Also the sporadic form is the most common form in prostates cancers. Furthermore, the most prostate cancer are adenocarcinoma at the prostatic capsule (PSA >10 ng/ml ; Gleason Score8 ≤ GS ≤ 10). Finally, the genetic analysis of patients and controls for the studied genes presented by the pvalue indicates that no association between the deletion of GSTM1 and the CYP1A1 3801T>C variant and prostate carcinogenesis. However, the deletion of GSTT1 and the double deletion of GSTM1/GSTT1 are involved in the development of prostate cancer. Thus the results of the VEGF-2578C/A variant show a significant difference with susceptibility to prostate cancer. Note de contenu : Annexes. Diplôme : Doctorat En ligne : ../theses/biologie/MED7571.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11409 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité MED/7571 MED/7571 Thèse Bibliothèque principale Thèses Disponible
