| Titre : |
Composition chimique et évaluation des activites biologiques des huiles essentielles de Pistacia atlantica Desf.et de Ferula vesceritensis Coss. & Dur. et synthese catalytique de nouveaux dérivés pipéridiniques |
| Type de document : |
texte imprimé |
| Auteurs : |
Ilhem Labed ep Zouad, Auteur ; Zahia Kabouche, Directeur de thèse |
| Editeur : |
جامعة الإخوة منتوري قسنطينة |
| Année de publication : |
2015 |
| Importance : |
211 f. |
| Format : |
30 cm. |
| Note générale : |
2 copies imprimes disponibles |
| Langues : |
Français (fre) |
| Catégories : |
Français - Anglais
Chimie
|
| Tags : |
Chimie pharmaceutique Ferula vesceritensis Coss. & Dur. antioxydante anticholinestérase antibactérienne couplage oxydant énamides pipéridines hydroboration hydrogénation Pistacia atlantica Desf. antioxidant anticholinesterase antibacterial oxidative coupling enamides hydrogenation hydrobration piperidines |
| Index. décimale : |
540 Chimie et sciences connexes |
| Résumé : |
In a first part we studied the chemical composition and biological activities of Pistacia
atlantica Desf. and Ferula vesceritensis Coss. & Dur. The GC and GC-MS analyses
showed that the essential oils of P. atlantica are rich in α-pinene, limonene and spatulenol,
while β-phellandrene, α-terpinene, β-elemene, γ-gurjunene and germacrene-B were found
as major components, for the first time for the essential oils of the genus Pistacia .
α-Pinene and β- pinene were predominant in the essential oils of Ferula vesceritensis;
however the first time that α-phellandrene, fenchylacetate, elixene, l'aristolene and cartol
were found as main components in the essential oils of the genus Ferula . The both essential
oils of P. atlantica . and F. vesceritensis exhibited a good antibacterial activity against
clinical isolated bacteria and food borne pathogens. The essential oils of P. atlantica
possess an important antioxidant effect which were determined using β-carotene-linoleic
acid, DPPH- and ABTS•+ -scavenging activities, metal chelating effect and CUPRAC
assays. The essential oils showed a moderate anticholinestérase activity compared with
galantamin for the inhibitory activity of principal enzymes of Alzheimer’s disease AChE
and BChE.
In a second part, we synthesized 12 new piperidine derivatives, which have been achieved
through [Cp*Ru]-catalyzed intermolecular coupling of allylic alcohols and propargylic
amides with water as the only side product, and demonstrated that the selective
oxidativecoupling cinnamyl alcohol derivatives and 2-substituted allylic alcohols. This
methodology allows the access to 3,4- and 3,5-disubstituted enamides as valuable
scaffolds for the preparation of 3-methylpiperidine derivatives through selective [Cp*Ru]
catalyzed alkene hydrogenation. |
| Diplôme : |
Doctorat |
| En ligne : |
../theses/chimie/LAB6834.pdf |
| Format de la ressource électronique : |
pdf |
| Permalink : |
index.php?lvl=notice_display&id=10126 |
Composition chimique et évaluation des activites biologiques des huiles essentielles de Pistacia atlantica Desf.et de Ferula vesceritensis Coss. & Dur. et synthese catalytique de nouveaux dérivés pipéridiniques [texte imprimé] / Ilhem Labed ep Zouad, Auteur ; Zahia Kabouche, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2015 . - 211 f. ; 30 cm. 2 copies imprimes disponibles Langues : Français ( fre)
| Catégories : |
Français - Anglais
Chimie
|
| Tags : |
Chimie pharmaceutique Ferula vesceritensis Coss. & Dur. antioxydante anticholinestérase antibactérienne couplage oxydant énamides pipéridines hydroboration hydrogénation Pistacia atlantica Desf. antioxidant anticholinesterase antibacterial oxidative coupling enamides hydrogenation hydrobration piperidines |
| Index. décimale : |
540 Chimie et sciences connexes |
| Résumé : |
In a first part we studied the chemical composition and biological activities of Pistacia
atlantica Desf. and Ferula vesceritensis Coss. & Dur. The GC and GC-MS analyses
showed that the essential oils of P. atlantica are rich in α-pinene, limonene and spatulenol,
while β-phellandrene, α-terpinene, β-elemene, γ-gurjunene and germacrene-B were found
as major components, for the first time for the essential oils of the genus Pistacia .
α-Pinene and β- pinene were predominant in the essential oils of Ferula vesceritensis;
however the first time that α-phellandrene, fenchylacetate, elixene, l'aristolene and cartol
were found as main components in the essential oils of the genus Ferula . The both essential
oils of P. atlantica . and F. vesceritensis exhibited a good antibacterial activity against
clinical isolated bacteria and food borne pathogens. The essential oils of P. atlantica
possess an important antioxidant effect which were determined using β-carotene-linoleic
acid, DPPH- and ABTS•+ -scavenging activities, metal chelating effect and CUPRAC
assays. The essential oils showed a moderate anticholinestérase activity compared with
galantamin for the inhibitory activity of principal enzymes of Alzheimer’s disease AChE
and BChE.
In a second part, we synthesized 12 new piperidine derivatives, which have been achieved
through [Cp*Ru]-catalyzed intermolecular coupling of allylic alcohols and propargylic
amides with water as the only side product, and demonstrated that the selective
oxidativecoupling cinnamyl alcohol derivatives and 2-substituted allylic alcohols. This
methodology allows the access to 3,4- and 3,5-disubstituted enamides as valuable
scaffolds for the preparation of 3-methylpiperidine derivatives through selective [Cp*Ru]
catalyzed alkene hydrogenation. |
| Diplôme : |
Doctorat |
| En ligne : |
../theses/chimie/LAB6834.pdf |
| Format de la ressource électronique : |
pdf |
| Permalink : |
index.php?lvl=notice_display&id=10126 |
|
Affiner la recherche Interroger des sources externesComposition chimique et évaluation des activites biologiques des huiles essentielles de Pistacia atlantica Desf.et de Ferula vesceritensis Coss. & Dur. et synthese catalytique de nouveaux dérivés pipéridiniques / Ilhem Labed ep Zouad
