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Auteur Nourredine Abadi |
Documents disponibles écrits par cet auteur (5)
Affiner la recherche Interroger des sources externesEtude de certains polymorphismes génétiques dans les métabolismes des folates et de l’homocystéine et anomalies de fermeture du tube neural / Amel Abbas ép. Tebdjoune
Titre : Etude de certains polymorphismes génétiques dans les métabolismes des folates et de l’homocystéine et anomalies de fermeture du tube neural Type de document : texte imprimé Auteurs : Amel Abbas ép. Tebdjoune, Auteur ; Nourredine Abadi, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2017 Importance : 152 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : Polymorphismes MTHFR C677T MTHFR A1298C MTR A2756G MTRR A66G RFC A80G CBS 844ins68 AFTN FOLATE HOMOCYSTEINE NTD 0التشوھات الخلقیةلانغلاق الأنبوب العصبي حمض الفولیك ھوموسستیین Index. décimale : 570 Sciences de la vie. Biologie Résumé : Neural tube defects (NTDs) represent a major cause of infant mortality among congenital malformations, whose pathogenesis remains poorly understood. In this study realized on an algerian population of affected children and their mothers, we investigated the frequency of many polymorphisms involved in the of folates / homocysteine metabolisms, Their possible contribution in the etiology of NTDs, as well as their influence on folates and homocysteine concentrations.
The mutations were determined by the PCR / RFLP method, the assay of the biochemical parameters was performed by chemiluminescence.
The analysis of genetic polymorphisms has shown that AG and AA variants of the G80A polymorphism of the RFC gene are associated with the increased risk in affected children.
Moreover, we have observed that the combined effect of C677T and A1298C polymorphisms in MTHFR gene, confers a risk for the occurrence of these abnormalities in our population .Indeed, statistical test of interaction between the two polymorphisms have shown that the combination of heterozygous genotypes(MTHFR 677CT/1298AC) elevate the risk in NTD cases (p <0.05).
These two polymorphisms ,in MTHFR gene, affects homocysteine metabolism in mothers of NTD cases leading to homocysteine concentration values higher in mothers with TT genotype of the C677T (p < 0.05) and that of AA genotype for the polymorphism A1298C (p <0.05).
For the polymorphism A2756G of the MTR gene, Although, Its association with NTDs risk appears to be negative, It was found to decrease the RBC folate level strengthen the contribution of A2756G mutation in NTDs occurrence (p <0.05).
Data on the association between MTRR A66G, CBS 844ins68 polymorphisms and plasma homocysteine and serum/RBC folate concentrations as well as the relationship between this polymorphisms and NTDs risk are inconclusive.
This original study by its primacy in Algeria and also in North Africa, both in terms of the diversity of polymorphisms examined and the nature of the population (children affected) deserves, encourages the extension of the study to a larger sample In order to show the interactive effect of these mutations on the occurrence of NTDs and on the rate of metabolites.
Diplôme : Doctorat en sciences En ligne : ../theses/biologie/ABB7166.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10447 Etude de certains polymorphismes génétiques dans les métabolismes des folates et de l’homocystéine et anomalies de fermeture du tube neural [texte imprimé] / Amel Abbas ép. Tebdjoune, Auteur ; Nourredine Abadi, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2017 . - 152 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Polymorphismes MTHFR C677T MTHFR A1298C MTR A2756G MTRR A66G RFC A80G CBS 844ins68 AFTN FOLATE HOMOCYSTEINE NTD 0التشوھات الخلقیةلانغلاق الأنبوب العصبي حمض الفولیك ھوموسستیین Index. décimale : 570 Sciences de la vie. Biologie Résumé : Neural tube defects (NTDs) represent a major cause of infant mortality among congenital malformations, whose pathogenesis remains poorly understood. In this study realized on an algerian population of affected children and their mothers, we investigated the frequency of many polymorphisms involved in the of folates / homocysteine metabolisms, Their possible contribution in the etiology of NTDs, as well as their influence on folates and homocysteine concentrations.
The mutations were determined by the PCR / RFLP method, the assay of the biochemical parameters was performed by chemiluminescence.
The analysis of genetic polymorphisms has shown that AG and AA variants of the G80A polymorphism of the RFC gene are associated with the increased risk in affected children.
Moreover, we have observed that the combined effect of C677T and A1298C polymorphisms in MTHFR gene, confers a risk for the occurrence of these abnormalities in our population .Indeed, statistical test of interaction between the two polymorphisms have shown that the combination of heterozygous genotypes(MTHFR 677CT/1298AC) elevate the risk in NTD cases (p <0.05).
These two polymorphisms ,in MTHFR gene, affects homocysteine metabolism in mothers of NTD cases leading to homocysteine concentration values higher in mothers with TT genotype of the C677T (p < 0.05) and that of AA genotype for the polymorphism A1298C (p <0.05).
For the polymorphism A2756G of the MTR gene, Although, Its association with NTDs risk appears to be negative, It was found to decrease the RBC folate level strengthen the contribution of A2756G mutation in NTDs occurrence (p <0.05).
Data on the association between MTRR A66G, CBS 844ins68 polymorphisms and plasma homocysteine and serum/RBC folate concentrations as well as the relationship between this polymorphisms and NTDs risk are inconclusive.
This original study by its primacy in Algeria and also in North Africa, both in terms of the diversity of polymorphisms examined and the nature of the population (children affected) deserves, encourages the extension of the study to a larger sample In order to show the interactive effect of these mutations on the occurrence of NTDs and on the rate of metabolites.
Diplôme : Doctorat en sciences En ligne : ../theses/biologie/ABB7166.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10447 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité ABB/7166 ABB/7166 Thèse Bibliothèque principale Thèses Disponible
Titre : Étude des gènes de prédisposition aux cancers colorectaux : Syndrome de Lynch Type de document : texte imprimé Auteurs : Hedia Ziada-Bouchaar, Auteur ; Nourredine Abadi, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2017 Importance : 157 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : Familles algériennes HNPCC Syndrome de Lynch MLH1 MSH2 gènes MMR Variability Temperature Forest , NDVI GIS MODIS Eastern Algeria Cartography العائلات الجزائرية السرطان القولوني المستقيمي الوراثي بدون زوائد متلازمة لينش MLH1و MMR Index. décimale : 570 Sciences de la vie. Biologie Résumé : Colorectal cancer (CRC) is currently a major public health problem in Algeria.
Among the hereditary forms of this cancer, Hereditary Non-Polyposis Colorectal Cancer
(HNPCC) is an autosomal dominant disorder characterized by the early onset of CRC. This
syndrome is linked to germline defects in Mismatch Repair (MMR) genes. The work we have
done has been devoted to studying the molecular correlation between CRC and mutations
occurring in the MLH1, MSH2 and MSH6 repair genes in 27 unrelated Algerian families.
The search for germline mutations was tested by sequencing all exons and adjacent
intronic sequences. Multiplex ligand-dependent probe amplification (MLPA) technique was
used for testing large genomic rearrangements (deletion / duplication), when we observed no
point mutations.
Pathogenic mutations were identified in 15 % of families with clinical suspicion on
HNPCC. Two novel variants described for the first time in Algerian families were identified
in MLH1, c.881_884delTCAGinsCATTCCT and a large deletion in MSH6 gene from a young
onset of CRC. Moreover, the variants of MSH2 gene: c.942+3A>T et c.1030C>T, the most
described ones, were also detected in our families. Furthermore, the families HNPCC caused
by MSH6 germline mutation may show an age of onset that is comparable to this of patients
with MLH1 and MSH2 mutations.
According to our results, we confirmed that MSH2, MLH1, and MSH6 contribute to
CRC susceptibility. This work represents the implementation of a diagnostic algorithm for the
identification of Lynch syndrome patients in Algerian families, which can assist in the
management of these patients and the medical supervision of their relatives at risk.
Diplôme : Doctorat en sciences En ligne : ../theses/biologie/ZIA7080.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10521 Étude des gènes de prédisposition aux cancers colorectaux : Syndrome de Lynch [texte imprimé] / Hedia Ziada-Bouchaar, Auteur ; Nourredine Abadi, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2017 . - 157 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Familles algériennes HNPCC Syndrome de Lynch MLH1 MSH2 gènes MMR Variability Temperature Forest , NDVI GIS MODIS Eastern Algeria Cartography العائلات الجزائرية السرطان القولوني المستقيمي الوراثي بدون زوائد متلازمة لينش MLH1و MMR Index. décimale : 570 Sciences de la vie. Biologie Résumé : Colorectal cancer (CRC) is currently a major public health problem in Algeria.
Among the hereditary forms of this cancer, Hereditary Non-Polyposis Colorectal Cancer
(HNPCC) is an autosomal dominant disorder characterized by the early onset of CRC. This
syndrome is linked to germline defects in Mismatch Repair (MMR) genes. The work we have
done has been devoted to studying the molecular correlation between CRC and mutations
occurring in the MLH1, MSH2 and MSH6 repair genes in 27 unrelated Algerian families.
The search for germline mutations was tested by sequencing all exons and adjacent
intronic sequences. Multiplex ligand-dependent probe amplification (MLPA) technique was
used for testing large genomic rearrangements (deletion / duplication), when we observed no
point mutations.
Pathogenic mutations were identified in 15 % of families with clinical suspicion on
HNPCC. Two novel variants described for the first time in Algerian families were identified
in MLH1, c.881_884delTCAGinsCATTCCT and a large deletion in MSH6 gene from a young
onset of CRC. Moreover, the variants of MSH2 gene: c.942+3A>T et c.1030C>T, the most
described ones, were also detected in our families. Furthermore, the families HNPCC caused
by MSH6 germline mutation may show an age of onset that is comparable to this of patients
with MLH1 and MSH2 mutations.
According to our results, we confirmed that MSH2, MLH1, and MSH6 contribute to
CRC susceptibility. This work represents the implementation of a diagnostic algorithm for the
identification of Lynch syndrome patients in Algerian families, which can assist in the
management of these patients and the medical supervision of their relatives at risk.
Diplôme : Doctorat en sciences En ligne : ../theses/biologie/ZIA7080.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10521 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité ZIA/7080 ZIA/7080 Thèse Bibliothèque principale Thèses Disponible
Titre : Étude pharmacogénétique du cancer du sein Type de document : texte imprimé Auteurs : Khadidja Sedrati, Auteur ; Nourredine Abadi, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2017 Importance : 113 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : cancer du sein pharmacogénétique polymorphisme chimiothérapie réponse génotypage phénotypage Index. décimale : 570 Sciences de la vie. Biologie Résumé : Personalized medicine is a concept designed to adapt the treatment of pathology to each individual through a better knowledge of the causes of inter-individual variabilities.
In the domain of oncology, the finding of great variability in the response to a drug, in terms of efficacy and toxicity, is far to be new. This inter-individual variability can come from genetic polymorphisms involved in the kinetics of drugs. Some SNPs are
suggested to be associated with improved or reduced efficacy of treatment. The aim of this study was to search for molecular markers that were predictive of the most effective chemotherapy regimens in breast cancer. We studied the contribution of polymorphisms IVS14 + 1G> A of DPYD gene, A313G of GSTP1 gene, C677T and A1298C of MTHFR gene, G2677T/A and C3435T of ABCB1 gene in response to FAC or FEC breast cancer’s chemotherapy.
Our cohort included 117 patients. Treatment outcomes were evaluated and genotyping of the various polymorphisms was carried out by RFLP PCR and direct sequencing.
Our study confirms that there is a significant correlation between the polymorphisms IVS14 + 1G> A of DPYD gene, C677T of MTHFR gene and response to treatment (p˂0.05). These results confirm the value of these polymorphisms as predictors of the efficacy of FAC or FEC chemotherapeutic treatments for breast cancer patients and, therefore, the benefit of a pharmacogenetic approach to identify new prognostic and predictive biomarkers, with a view to personalized treatment.
Diplôme : Doctorat en sciences En ligne : ../theses/biologie/SED7146.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10457 Étude pharmacogénétique du cancer du sein [texte imprimé] / Khadidja Sedrati, Auteur ; Nourredine Abadi, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2017 . - 113 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : cancer du sein pharmacogénétique polymorphisme chimiothérapie réponse génotypage phénotypage Index. décimale : 570 Sciences de la vie. Biologie Résumé : Personalized medicine is a concept designed to adapt the treatment of pathology to each individual through a better knowledge of the causes of inter-individual variabilities.
In the domain of oncology, the finding of great variability in the response to a drug, in terms of efficacy and toxicity, is far to be new. This inter-individual variability can come from genetic polymorphisms involved in the kinetics of drugs. Some SNPs are
suggested to be associated with improved or reduced efficacy of treatment. The aim of this study was to search for molecular markers that were predictive of the most effective chemotherapy regimens in breast cancer. We studied the contribution of polymorphisms IVS14 + 1G> A of DPYD gene, A313G of GSTP1 gene, C677T and A1298C of MTHFR gene, G2677T/A and C3435T of ABCB1 gene in response to FAC or FEC breast cancer’s chemotherapy.
Our cohort included 117 patients. Treatment outcomes were evaluated and genotyping of the various polymorphisms was carried out by RFLP PCR and direct sequencing.
Our study confirms that there is a significant correlation between the polymorphisms IVS14 + 1G> A of DPYD gene, C677T of MTHFR gene and response to treatment (p˂0.05). These results confirm the value of these polymorphisms as predictors of the efficacy of FAC or FEC chemotherapeutic treatments for breast cancer patients and, therefore, the benefit of a pharmacogenetic approach to identify new prognostic and predictive biomarkers, with a view to personalized treatment.
Diplôme : Doctorat en sciences En ligne : ../theses/biologie/SED7146.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10457 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité SED/7146 SED/7146 Thèse Bibliothèque principale Thèses Disponible
Titre : Identification des facteurs de risque biologiques et génétiques de l'athérosclérose coronarienne dans la population algérienne Type de document : texte imprimé Auteurs : Ouarda Semmame- Bensakesli, Auteur ; Nourredine Abadi, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2017 Importance : 137 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : infarctus du myocarde Athérosclérose lipides apolipoprotéine A1 polymorphisme génétique enzyme de conversion de l’angiotensine homocystéine myocardial infarction Atherosclerosis lipid Apolipoprotein A1 Genepolymorphism angiotensin converting enzyme homocysteine مرض احتشاء القلب تصلب الشرایین التاجیة الدھون حمض الھوموسیسنیین تعدد الأشكال الجینیة أبولیبوبروتین 1Aانزیم تحویل الانجیوتنسین Index. décimale : 570 Sciences de la vie. Biologie Résumé : "In coronary atherosclerosis, there are many genes whose products are involved in the development of the disease and for which a genetic polymorphism has been described.
The objective of this study was to assess the effect of the -75G/A polymorphism of the apolipoprotein A1 gene (Apo A1) and the I/D polymorphism of the angiotensin converting
enzyme (ACE) on the risk of myocardial infarction (MI).
Our case-control study included 319 subjects who received a full lipid profile (TC, TG, HDL, LDL) and a homocysteine assay. The study population was divided into two groups: control group (160 apparently healthy subjects) and patient group (159 subjects with MI). Genotyping of the Apo A1 polymorphism was done by a PCR RFLP using the restriction enzyme MspI. Genotyping of ACE polymorphism was determined by direct PCR
Our results show that the mutated genotype AA of Apo A1 is not significantly associated with the risk of MI (OR = 0.74, 95% CI 0.27-2.008). However carriers of the genotype AA, either in control or in patients, have higher serum levels of HDL. Regarding the DD genotype of ACE, patients have significantly higher frequencies compared to controls (p = 0.02).
In conclusion, individuals with the AA genotype appear to be likely to have a lower risk of MI as a result of its effect on higher serum concentrations of HDL. Furthermore our study confirms the supposed role of the DD genotype of ACE as a marker of MI in our population. Additional studies are needed to confirm this findingDiplôme : Doctorat en sciences En ligne : ../theses/biologie/SEM7008.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10380 Identification des facteurs de risque biologiques et génétiques de l'athérosclérose coronarienne dans la population algérienne [texte imprimé] / Ouarda Semmame- Bensakesli, Auteur ; Nourredine Abadi, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2017 . - 137 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : infarctus du myocarde Athérosclérose lipides apolipoprotéine A1 polymorphisme génétique enzyme de conversion de l’angiotensine homocystéine myocardial infarction Atherosclerosis lipid Apolipoprotein A1 Genepolymorphism angiotensin converting enzyme homocysteine مرض احتشاء القلب تصلب الشرایین التاجیة الدھون حمض الھوموسیسنیین تعدد الأشكال الجینیة أبولیبوبروتین 1Aانزیم تحویل الانجیوتنسین Index. décimale : 570 Sciences de la vie. Biologie Résumé : "In coronary atherosclerosis, there are many genes whose products are involved in the development of the disease and for which a genetic polymorphism has been described.
The objective of this study was to assess the effect of the -75G/A polymorphism of the apolipoprotein A1 gene (Apo A1) and the I/D polymorphism of the angiotensin converting
enzyme (ACE) on the risk of myocardial infarction (MI).
Our case-control study included 319 subjects who received a full lipid profile (TC, TG, HDL, LDL) and a homocysteine assay. The study population was divided into two groups: control group (160 apparently healthy subjects) and patient group (159 subjects with MI). Genotyping of the Apo A1 polymorphism was done by a PCR RFLP using the restriction enzyme MspI. Genotyping of ACE polymorphism was determined by direct PCR
Our results show that the mutated genotype AA of Apo A1 is not significantly associated with the risk of MI (OR = 0.74, 95% CI 0.27-2.008). However carriers of the genotype AA, either in control or in patients, have higher serum levels of HDL. Regarding the DD genotype of ACE, patients have significantly higher frequencies compared to controls (p = 0.02).
In conclusion, individuals with the AA genotype appear to be likely to have a lower risk of MI as a result of its effect on higher serum concentrations of HDL. Furthermore our study confirms the supposed role of the DD genotype of ACE as a marker of MI in our population. Additional studies are needed to confirm this findingDiplôme : Doctorat en sciences En ligne : ../theses/biologie/SEM7008.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10380 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité SEM/7008 SEM/7008 Thèse Bibliothèque principale Thèses Disponible
Titre : Profil épidémiologique et métabolique du surpoids et de l'obèsité chez les adultes constantinois. Type de document : texte imprimé Auteurs : souhaila dalichaouch, Auteur ; Leïla Rouabah, Directeur de thèse ; Nourredine Abadi, Directeur de thèse Mention d'édition : 10/12/2013 Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2013 Importance : 259 f. Format : 30 cm. Note générale : 1 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : Biochimie et Biologie Cellulaire et Moléculaire:Biologie Cellulaire et Moléculaire Surpoids Obésité Adultes Prévalence Variables d’adiposité Facteurs de risque Constantine Overweight Obesity Adults Prevalence adiposity variables Risk Factors زيادة الوزن السمنة الكبار انتشار المتغيرات السمنة عوامل المخاطرة قسنطينة Index. décimale : 570 Sciences de la vie. Biologie Résumé :
In Algeria, as in all countries in the developing world, obesity has become more common in adults. This study aims to determine the prevalence of overweight and obesity among adults in constantine and to investigate the risk factors associated. A cross-sectional study with cluster sampling allowed us to estimate the prevalence of all categories of body mass index. To this end, 1143 adults living in Constantine, were interviewed. Individual meetings include a measurement anthropometric and a guided interview using a questionnaire. The prevalence of overweight and obesity is respectively 32,5% and 30,9%. Women are more affected by obesity than men. Obesity is more common in people with no professional activity. Similarly, the level of education and the prevalence of obesity are inversely correlated. This study shows that the increase is not limited to BMI for adults TT, WHR and RTG increase with age regardless of sex. The abdominal obesity according to IDF and according to the U.S.NCEP ATP III respectively found in 68,15% and 51,96% of subjects. It is more common in women and 55-64 years. The abdominal obesity according to WHR was 52,3%, WHR and RTG are higher in women. The results of the binary logistic regression analysis shows that after adjustment for socioeconomic variables and lifestyle, the prevalence of overweight and obesity is significantly different according to age, marital status, educational level, sedentary and smoking status for men. The status of overweight and obesity is linked to many diseases, some of which are very serious. The analysis of this study revealed associations between overweight / obesity and hypertension, diabetes and cardiovascular diseases. Metabolic and hormonal abnormalities are frequent and many readily associated in obese upper bound his cardiovascular risk and hampering their quality of life. The results of biological analysis of this study show that 27,0% of obese patients have hyperglycemia. 11,2% of obese hypercholesterolemia and 17,8% had hypertriglyceridemia. The leptin is higher in obese compared to controls. Serum cortisol hormone profile appears to be altered in obese subjects compared to controls in the study. The adult obesity is a major public health problems of our days would further increase the risk of chronic diseases if preventive measures are not taken. Obesity is a serious disease which causes significant health care costs. Preventive measures are urgently taken.
Promote a healthy and balanced diet and actively promote physical activity should be a priority in the prevention of obesity in childhood.
Note de contenu :
Annexes.Diplôme : Doctorat en sciences En ligne : ../theses/biologie/DAL7821.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11653 Profil épidémiologique et métabolique du surpoids et de l'obèsité chez les adultes constantinois. [texte imprimé] / souhaila dalichaouch, Auteur ; Leïla Rouabah, Directeur de thèse ; Nourredine Abadi, Directeur de thèse . - 10/12/2013 . - جامعة الإخوة منتوري قسنطينة, 2013 . - 259 f. ; 30 cm.
1 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Biochimie et Biologie Cellulaire et Moléculaire:Biologie Cellulaire et Moléculaire Surpoids Obésité Adultes Prévalence Variables d’adiposité Facteurs de risque Constantine Overweight Obesity Adults Prevalence adiposity variables Risk Factors زيادة الوزن السمنة الكبار انتشار المتغيرات السمنة عوامل المخاطرة قسنطينة Index. décimale : 570 Sciences de la vie. Biologie Résumé :
In Algeria, as in all countries in the developing world, obesity has become more common in adults. This study aims to determine the prevalence of overweight and obesity among adults in constantine and to investigate the risk factors associated. A cross-sectional study with cluster sampling allowed us to estimate the prevalence of all categories of body mass index. To this end, 1143 adults living in Constantine, were interviewed. Individual meetings include a measurement anthropometric and a guided interview using a questionnaire. The prevalence of overweight and obesity is respectively 32,5% and 30,9%. Women are more affected by obesity than men. Obesity is more common in people with no professional activity. Similarly, the level of education and the prevalence of obesity are inversely correlated. This study shows that the increase is not limited to BMI for adults TT, WHR and RTG increase with age regardless of sex. The abdominal obesity according to IDF and according to the U.S.NCEP ATP III respectively found in 68,15% and 51,96% of subjects. It is more common in women and 55-64 years. The abdominal obesity according to WHR was 52,3%, WHR and RTG are higher in women. The results of the binary logistic regression analysis shows that after adjustment for socioeconomic variables and lifestyle, the prevalence of overweight and obesity is significantly different according to age, marital status, educational level, sedentary and smoking status for men. The status of overweight and obesity is linked to many diseases, some of which are very serious. The analysis of this study revealed associations between overweight / obesity and hypertension, diabetes and cardiovascular diseases. Metabolic and hormonal abnormalities are frequent and many readily associated in obese upper bound his cardiovascular risk and hampering their quality of life. The results of biological analysis of this study show that 27,0% of obese patients have hyperglycemia. 11,2% of obese hypercholesterolemia and 17,8% had hypertriglyceridemia. The leptin is higher in obese compared to controls. Serum cortisol hormone profile appears to be altered in obese subjects compared to controls in the study. The adult obesity is a major public health problems of our days would further increase the risk of chronic diseases if preventive measures are not taken. Obesity is a serious disease which causes significant health care costs. Preventive measures are urgently taken.
Promote a healthy and balanced diet and actively promote physical activity should be a priority in the prevention of obesity in childhood.
Note de contenu :
Annexes.Diplôme : Doctorat en sciences En ligne : ../theses/biologie/DAL7821.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11653 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité DAL/7821 DAL/7821 Thèse Bibliothèque principale Thèses Disponible
