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Auteur Amar Zellagui |
Documents disponibles écrits par cet auteur (2)
Affiner la recherche Interroger des sources externesEtude phytochimique et valorisation biologique de deux plantes, Genista microcephala Coss & Dur (Fabaceae) et Jurinea humilis DC (Asteraseae). / Djamila Maanani
Titre : Etude phytochimique et valorisation biologique de deux plantes, Genista microcephala Coss & Dur (Fabaceae) et Jurinea humilis DC (Asteraseae). Type de document : texte imprimé Auteurs : Djamila Maanani, Auteur ; Salah Rhouati, Directeur de thèse ; Amar Zellagui, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2018 Importance : 177 f. Format : 30 cm. Note générale : Doctorat 3éme CYCLE LMD.
2 copies imprimées disponiblesLangues : Français (fre) Catégories : Français - Anglais
ChimieTags : Chimie Organique:Phytochimie Activité antimicrobienne activité antioxydant acides gras Genista microcephala Jurinéa humilis composés phénoliques Antimicrobial activity antioxidant activity fatty acids Jurinea humilis phenolic compounds النشاط المضاد للبكتيريا النشاط المضاد للأكسدة الأحماض الدهنية المركبات الفينولي Index. décimale : 540 Chimie et sciences connexes Résumé :
This work is concerning the phytochemical study of two Algerian plants, the first belonging to the Fabaceae family (Genista microcephala coss & dur) and Asteraceae family (Jurinea humilis DC). The phytochemical study of the two Algerian medicinal plants allowed the identification of five isoflavonoids from ethyl acetate and butanol extracts of G. microcephala and three flavonoids from butanol extract of J.humilis, isolated for the first time in both plants, The structurs of compounds were elucidated by various spectroscopic methods spectral: 1D and 2D NMR (1H, 13C, DEPT, HMBC and HMQC), UV, mass spectrometry (MS) and by comparison with lettirature valrieus. The biological study carried out to determine the phenolic content and to evaluate the antioxidant and antimicrobial activities of Genista microcephala. Antioxidant activity was evaluated by various in vitro tests, including Ferric Ion Reducing Activity (FRAP), Cupric Ion Reducing Antioxidant Capacity (CUPRAC), and total antioxidant capacities (TAC). The antimicrobial activity of ethyl acetate and butanolic extracts of G. microcephala in addition of fatty acids content of different parts of plant was evaluated against human pathogenic bacteria, fish bacteria and yeast. The used methods were agar diffusion method and the determination of minimal bactericidal and fungicidal concentrations (MBC and MFC). Ethyl acetate extract was the most active regarding antioxidant and antimicrobienne assays. The tested activity seems to be due to the high content of this extract on isoflavonoids.Note de contenu :
annexeDiplôme : Doctorat En ligne : ../theses/chimie/MAA7436.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11175 Etude phytochimique et valorisation biologique de deux plantes, Genista microcephala Coss & Dur (Fabaceae) et Jurinea humilis DC (Asteraseae). [texte imprimé] / Djamila Maanani, Auteur ; Salah Rhouati, Directeur de thèse ; Amar Zellagui, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2018 . - 177 f. ; 30 cm.
Doctorat 3éme CYCLE LMD.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Chimie Organique:Phytochimie Activité antimicrobienne activité antioxydant acides gras Genista microcephala Jurinéa humilis composés phénoliques Antimicrobial activity antioxidant activity fatty acids Jurinea humilis phenolic compounds النشاط المضاد للبكتيريا النشاط المضاد للأكسدة الأحماض الدهنية المركبات الفينولي Index. décimale : 540 Chimie et sciences connexes Résumé :
This work is concerning the phytochemical study of two Algerian plants, the first belonging to the Fabaceae family (Genista microcephala coss & dur) and Asteraceae family (Jurinea humilis DC). The phytochemical study of the two Algerian medicinal plants allowed the identification of five isoflavonoids from ethyl acetate and butanol extracts of G. microcephala and three flavonoids from butanol extract of J.humilis, isolated for the first time in both plants, The structurs of compounds were elucidated by various spectroscopic methods spectral: 1D and 2D NMR (1H, 13C, DEPT, HMBC and HMQC), UV, mass spectrometry (MS) and by comparison with lettirature valrieus. The biological study carried out to determine the phenolic content and to evaluate the antioxidant and antimicrobial activities of Genista microcephala. Antioxidant activity was evaluated by various in vitro tests, including Ferric Ion Reducing Activity (FRAP), Cupric Ion Reducing Antioxidant Capacity (CUPRAC), and total antioxidant capacities (TAC). The antimicrobial activity of ethyl acetate and butanolic extracts of G. microcephala in addition of fatty acids content of different parts of plant was evaluated against human pathogenic bacteria, fish bacteria and yeast. The used methods were agar diffusion method and the determination of minimal bactericidal and fungicidal concentrations (MBC and MFC). Ethyl acetate extract was the most active regarding antioxidant and antimicrobienne assays. The tested activity seems to be due to the high content of this extract on isoflavonoids.Note de contenu :
annexeDiplôme : Doctorat En ligne : ../theses/chimie/MAA7436.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11175 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité MAA/7436 MAA/7436 Thèse Bibliothèque principale Thèses Disponible
Titre : Secondary metabolic components and biological effectiveness study on two species Thymelaea microphyllaand Gnidia somalensis Type de document : texte imprimé Auteurs : Ali Saeed Noman Labib, Auteur ; Amar Zellagui, Directeur de thèse ; Salah Rhouati, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2017 Importance : 234 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Anglais (eng) Catégories : Français - Anglais
ChimieTags : Thymelaea microphylla antioxidant activity antimicrobialactivity microphybenzimidazol antioxidant activité antimicrobialactivités الفعالية المضادة للأكسد الفعالية المضادة للميكروبات Index. décimale : 540 Chimie et sciences connexes Résumé : The main objective of our work is phytochemical studies and evaluation
of secondary metabolite products extracted from Thymelaeaceae family
which is rich in biological active phenolic compounds. So, we choose
Thymelaea microphylla, which grows in Algeria. In addition to another plant
from the same family; Gnidia somalensis growing in Yemen.
Our study also, devoted to the evaluation and effectiveness of the plant
extracts and pure compounds against cancer cells. We used the ELISA and
xCELLigence assay technics for determining the inhibition of fractions and
pure compounds in vitro, against HeLa cells (human uterus carcinoma) and
C6 cells (rat brain tumor). Which have shown positive results, especially for
fractions that have a high activity compared with the reference compound. In
addition, we have got a significant results by testing the pure compounds
(Prestegane B, daphnoretin and trans-tiliroside) which gave a positive results.
On the other hand, we were able to isolated 10 compounds from T.
microphylla:
• Two lignan lactones.
• One bicoumarin.
• Four flavonoids.
• Two spiro lactones.
• One new alkaloid (microphybenzimidazole).
Also, we have separated 12 phenolic compounds from the plant Gnidia
somalensis: 6 polysubstituted cinnamic acid derivatives and 6 flavonoids.
We used different chromatographic methods for separation and
purification (Column chromatography CC, thin layer chromatography TLC),
and spectroscopic tools for structure identification (HPLC LC-MS, HPLCTOF), ID (Tf -NMR, 13C- NMR and DEPT) and 2D (HMQC, HMBC and
COSY).
Diplôme : Doctorat en sciences En ligne : ../theses/chimie/LAB7152.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10431 Secondary metabolic components and biological effectiveness study on two species Thymelaea microphyllaand Gnidia somalensis [texte imprimé] / Ali Saeed Noman Labib, Auteur ; Amar Zellagui, Directeur de thèse ; Salah Rhouati, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2017 . - 234 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Anglais (eng)
Catégories : Français - Anglais
ChimieTags : Thymelaea microphylla antioxidant activity antimicrobialactivity microphybenzimidazol antioxidant activité antimicrobialactivités الفعالية المضادة للأكسد الفعالية المضادة للميكروبات Index. décimale : 540 Chimie et sciences connexes Résumé : The main objective of our work is phytochemical studies and evaluation
of secondary metabolite products extracted from Thymelaeaceae family
which is rich in biological active phenolic compounds. So, we choose
Thymelaea microphylla, which grows in Algeria. In addition to another plant
from the same family; Gnidia somalensis growing in Yemen.
Our study also, devoted to the evaluation and effectiveness of the plant
extracts and pure compounds against cancer cells. We used the ELISA and
xCELLigence assay technics for determining the inhibition of fractions and
pure compounds in vitro, against HeLa cells (human uterus carcinoma) and
C6 cells (rat brain tumor). Which have shown positive results, especially for
fractions that have a high activity compared with the reference compound. In
addition, we have got a significant results by testing the pure compounds
(Prestegane B, daphnoretin and trans-tiliroside) which gave a positive results.
On the other hand, we were able to isolated 10 compounds from T.
microphylla:
• Two lignan lactones.
• One bicoumarin.
• Four flavonoids.
• Two spiro lactones.
• One new alkaloid (microphybenzimidazole).
Also, we have separated 12 phenolic compounds from the plant Gnidia
somalensis: 6 polysubstituted cinnamic acid derivatives and 6 flavonoids.
We used different chromatographic methods for separation and
purification (Column chromatography CC, thin layer chromatography TLC),
and spectroscopic tools for structure identification (HPLC LC-MS, HPLCTOF), ID (Tf -NMR, 13C- NMR and DEPT) and 2D (HMQC, HMBC and
COSY).
Diplôme : Doctorat en sciences En ligne : ../theses/chimie/LAB7152.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10431 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité LAB/7152 LAB/7152 Thèse Bibliothèque principale Thèses Disponible
