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Auteur Abdelmalek Bouraiou |
Documents disponibles écrits par cet auteur (4)
Affiner la recherche Interroger des sources externesConception et evaluation de l’activité biologique de nouveaux dérivés indoliziniques et furaniques et expérimentation de nouveaux procédés pour l’obtention de flavonols. / Roumaissa Belguedj
Titre : Conception et evaluation de l’activité biologique de nouveaux dérivés indoliziniques et furaniques et expérimentation de nouveaux procédés pour l’obtention de flavonols. Type de document : texte imprimé Auteurs : Roumaissa Belguedj, Auteur ; Abdelmalek Bouraiou, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2018 Importance : 247 f. Format : 30 cm. Note générale : Doctorat 3éme CYCLE LMD.
2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Chimie: chimie organique ylure de pyridinium cycloaddition 1,3-dipolaire réactions multicomposants micro-ondes indolizine 2,3-dihydrofurane flavonoïdes réaction AFO mécanochimie liquides ioniques activités biologiques pyridinium ylide 1,3-dipolar cycloaddition multi-component reactions microwaves 2,3-dihydrofuran flavonoids AFO reaction Mechanochemistry ionic liquids Biological activity إلير البيريدينيوم تفاعل اN1ضافة الحلقية- 3,1ثنائي القطب تفاعل متعدد المكونات ميكروايف، الف67فونويد, تفاعل ) AFOال( كيمياء لا ميكانيكية ال سوائل أيونية النشاط البيولوجي Index. décimale : 540 Chimie et sciences connexes Résumé :
The aim of the first part of this work is the elaboration of new hybrid compounds containing different heterocycles such as indolizine, benzindolizine, imidazole, quinoline, benzimidazole or furan by the exploitation of the reactivity of some pyridinium-based ylides having the imidazole, benzimidazole or quinoline nucleus. The prepared compounds were subjected to biological evaluation. This part is subdivided into 3 chapters: In the first chapter, the biological activities and some synthesis methods of indolizine derivatives as well as some concepts about the 1,3-dipolar cycloaddition reaction were given. The results concerning the synthesis of the hybrid derivatives (benz) indolizine / (benz) imidazole and indolizine / quinoline were presented in an experimental part. In the second chapter, after a brief bibliographical overview concerning biological applications of some 2,3-dihydrofuran derivatives, we have presented the most widely used synthetic methods for this class of compounds. The discussion of the results concerning the synthesis of the benzimidazole / 2,3-dihydrofuran hybrid derivatives via the multicomponent reaction were discussed in the next section. In the third chapter, which was devoted to the biological evaluation of certain prepared compounds, some basic notions about this part (tuberculosis, leishmaniasis and oxidative stress) were given. The results that we have obtained, were exposed and commented in results and discussion part. The second part of this work is in relation with modern chemistry. This part was devoted to the experimentation of the AFO reaction by two modern approaches (mechanochemistry and the use of ionic liquids). After a bibliographic overview of some modern synthesis technologies and alternatives methodes to volatile solvents, the results obtained were discussed in the results and discussion section. Each part was closed by an experimental section which details the experimental protocols, as well as the spectroscopic and physical characteristics of the compounds obtained. The molecules prepared have been identified by the usual spectral methods such as IR, 1H and 13C NMR. The original products have been further characterized by high resolution mass spectroscopy and / or X-ray diffraction.
Note de contenu :
Annexes.Diplôme : Doctorat En ligne : ../theses/chimie/BEL7407.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11059 Conception et evaluation de l’activité biologique de nouveaux dérivés indoliziniques et furaniques et expérimentation de nouveaux procédés pour l’obtention de flavonols. [texte imprimé] / Roumaissa Belguedj, Auteur ; Abdelmalek Bouraiou, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2018 . - 247 f. ; 30 cm.
Doctorat 3éme CYCLE LMD.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Chimie: chimie organique ylure de pyridinium cycloaddition 1,3-dipolaire réactions multicomposants micro-ondes indolizine 2,3-dihydrofurane flavonoïdes réaction AFO mécanochimie liquides ioniques activités biologiques pyridinium ylide 1,3-dipolar cycloaddition multi-component reactions microwaves 2,3-dihydrofuran flavonoids AFO reaction Mechanochemistry ionic liquids Biological activity إلير البيريدينيوم تفاعل اN1ضافة الحلقية- 3,1ثنائي القطب تفاعل متعدد المكونات ميكروايف، الف67فونويد, تفاعل ) AFOال( كيمياء لا ميكانيكية ال سوائل أيونية النشاط البيولوجي Index. décimale : 540 Chimie et sciences connexes Résumé :
The aim of the first part of this work is the elaboration of new hybrid compounds containing different heterocycles such as indolizine, benzindolizine, imidazole, quinoline, benzimidazole or furan by the exploitation of the reactivity of some pyridinium-based ylides having the imidazole, benzimidazole or quinoline nucleus. The prepared compounds were subjected to biological evaluation. This part is subdivided into 3 chapters: In the first chapter, the biological activities and some synthesis methods of indolizine derivatives as well as some concepts about the 1,3-dipolar cycloaddition reaction were given. The results concerning the synthesis of the hybrid derivatives (benz) indolizine / (benz) imidazole and indolizine / quinoline were presented in an experimental part. In the second chapter, after a brief bibliographical overview concerning biological applications of some 2,3-dihydrofuran derivatives, we have presented the most widely used synthetic methods for this class of compounds. The discussion of the results concerning the synthesis of the benzimidazole / 2,3-dihydrofuran hybrid derivatives via the multicomponent reaction were discussed in the next section. In the third chapter, which was devoted to the biological evaluation of certain prepared compounds, some basic notions about this part (tuberculosis, leishmaniasis and oxidative stress) were given. The results that we have obtained, were exposed and commented in results and discussion part. The second part of this work is in relation with modern chemistry. This part was devoted to the experimentation of the AFO reaction by two modern approaches (mechanochemistry and the use of ionic liquids). After a bibliographic overview of some modern synthesis technologies and alternatives methodes to volatile solvents, the results obtained were discussed in the results and discussion section. Each part was closed by an experimental section which details the experimental protocols, as well as the spectroscopic and physical characteristics of the compounds obtained. The molecules prepared have been identified by the usual spectral methods such as IR, 1H and 13C NMR. The original products have been further characterized by high resolution mass spectroscopy and / or X-ray diffraction.
Note de contenu :
Annexes.Diplôme : Doctorat En ligne : ../theses/chimie/BEL7407.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11059 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité BEL/7407 BEL/7407 Thèse Bibliothèque principale Thèses Disponible
Titre : Les dérivés hétérocycliques : Conception et synthèse de nouveaux dérivés Poly-hétérocyliques à activité potentielle. Type de document : texte imprimé Auteurs : Esma Lamera, Auteur ; Abdelmalek Bouraiou, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2019 Importance : 238 f. Format : 30 cm. Note générale : Doctorat 3éme CYCLE LMD.
2 copies imprimées disponiblesLangues : Français (fre) Catégories : Français - Anglais
ChimieTags : Chimie: chimie organique Les polyhétérocycles azotés Pyrazole Réaction multicomposants azépine DMAP One pot Phtalazine Association Indole Indazole Carbazole activité biologique Nitrogen polyheterocycles Multicomponent reaction azepine indazole biological activity متعدد الحلقات النيتروجينية بيرازول تفاعل متعدد المكونات أزيبين وعاء
واحد فتالازين جمع أندول أندازول كاربازول نشاط بيولوجي"Index. décimale : 540 Chimie et sciences connexes Résumé :
The objective of the works presented in this thesis is the development of new access routes to a variety of nitrogen polyheterocyclic compounds containing in their structures a phthalazine nucleus fused to other cycles using a multicomponents reactions. The first chapter begins with a bibliographic overview of multi-component reactions. This chapter is divides into two parts: The first part was dedicated to the development of a simple and efficient synthesis of 1H-pyrazolo[1,2-b]phthalazine by the use of DMAP as an effective catalyst of the threecomponent reaction between malononitrile, phthalazine and aromatics aldehydes. In the second part, we proceeded to the synthesis of a range of 1H-indazolo[1,2-b] phthalazine-1,6,11-trione, following the Bazgir reaction between the aromatic aldehyde, the phathalhydrazide, and cyclohexane-1,3-dione, with the use of CF3COOH as a new catalyst for this reaction. The second chapter is devoted to the preparation of new heterocyclic derivatives by the association of multicomponents reactions with others reactions. This chapter is divided into 2 parts: The first part was devoted to the preparation of new polyheterocycles carbazole via a one pot reaction, by the combination of the Fischer indolization reaction with a multicomponent reaction of Bazgir. The second part was dedicated to the synthesis of a variety of original polyheterocyclics compounds of tetrahydroazepinophthalazine, by the combination of the Beckman rearrangement reaction with a multicomponent reaction of Bazgir. In the third chapter, which was devoted to the biological evaluation of some prepared compounds, we gave some basic notions about this part (antioxidant activity, Alzheimer's disease and cytotoxicity). The results we have reached have been presented and commented on in the results and discussion section. Each chapter was closed by an experimental section which details the experimental protocols, as well as the spectroscopic and physical characteristics of the compounds obtained. The molecules prepared were identified by the usual spectral methods such as IR, 1H and 13C NMR, and mass spectroscopy. The structures of some compounds have been established by X-ray diffraction.Note de contenu :
Annexes.Diplôme : Doctorat En ligne : ../theses/chimie/LAM7510.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11345 Les dérivés hétérocycliques : Conception et synthèse de nouveaux dérivés Poly-hétérocyliques à activité potentielle. [texte imprimé] / Esma Lamera, Auteur ; Abdelmalek Bouraiou, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2019 . - 238 f. ; 30 cm.
Doctorat 3éme CYCLE LMD.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Chimie: chimie organique Les polyhétérocycles azotés Pyrazole Réaction multicomposants azépine DMAP One pot Phtalazine Association Indole Indazole Carbazole activité biologique Nitrogen polyheterocycles Multicomponent reaction azepine indazole biological activity متعدد الحلقات النيتروجينية بيرازول تفاعل متعدد المكونات أزيبين وعاء
واحد فتالازين جمع أندول أندازول كاربازول نشاط بيولوجي"Index. décimale : 540 Chimie et sciences connexes Résumé :
The objective of the works presented in this thesis is the development of new access routes to a variety of nitrogen polyheterocyclic compounds containing in their structures a phthalazine nucleus fused to other cycles using a multicomponents reactions. The first chapter begins with a bibliographic overview of multi-component reactions. This chapter is divides into two parts: The first part was dedicated to the development of a simple and efficient synthesis of 1H-pyrazolo[1,2-b]phthalazine by the use of DMAP as an effective catalyst of the threecomponent reaction between malononitrile, phthalazine and aromatics aldehydes. In the second part, we proceeded to the synthesis of a range of 1H-indazolo[1,2-b] phthalazine-1,6,11-trione, following the Bazgir reaction between the aromatic aldehyde, the phathalhydrazide, and cyclohexane-1,3-dione, with the use of CF3COOH as a new catalyst for this reaction. The second chapter is devoted to the preparation of new heterocyclic derivatives by the association of multicomponents reactions with others reactions. This chapter is divided into 2 parts: The first part was devoted to the preparation of new polyheterocycles carbazole via a one pot reaction, by the combination of the Fischer indolization reaction with a multicomponent reaction of Bazgir. The second part was dedicated to the synthesis of a variety of original polyheterocyclics compounds of tetrahydroazepinophthalazine, by the combination of the Beckman rearrangement reaction with a multicomponent reaction of Bazgir. In the third chapter, which was devoted to the biological evaluation of some prepared compounds, we gave some basic notions about this part (antioxidant activity, Alzheimer's disease and cytotoxicity). The results we have reached have been presented and commented on in the results and discussion section. Each chapter was closed by an experimental section which details the experimental protocols, as well as the spectroscopic and physical characteristics of the compounds obtained. The molecules prepared were identified by the usual spectral methods such as IR, 1H and 13C NMR, and mass spectroscopy. The structures of some compounds have been established by X-ray diffraction.Note de contenu :
Annexes.Diplôme : Doctorat En ligne : ../theses/chimie/LAM7510.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11345 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité LAM/7510 LAM/7510 Thèse Bibliothèque principale Thèses Disponible
Titre : Synthèse des cetones et esters quinoleiques alpha, beta-insatures et préparation des déivés d'aziridine et de pyrazole Type de document : texte imprimé Auteurs : Abdelmalek Bouraiou ; Univ. de Constantine, Éditeur scientifique ; Salah Rhouati, Directeur de thèse Année de publication : 2004 Importance : 144 f. Note générale : 01 Disponible à la salle de recherche 02 Diponibles au magazin de la bibliothéque centrale Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Pyrrole Quinoléines Réactif de Vilsmeier Esters alpha,beta-insatures Azidirines Pyrazoles Flavonones Pyrroline Chalcones Index. décimale : 540 Chimie et sciences connexes Permalink : index.php?lvl=notice_display&id=4057 Synthèse des cetones et esters quinoleiques alpha, beta-insatures et préparation des déivés d'aziridine et de pyrazole [texte imprimé] / Abdelmalek Bouraiou ; Univ. de Constantine, Éditeur scientifique ; Salah Rhouati, Directeur de thèse . - 2004 . - 144 f.
01 Disponible à la salle de recherche 02 Diponibles au magazin de la bibliothéque centrale
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Pyrrole Quinoléines Réactif de Vilsmeier Esters alpha,beta-insatures Azidirines Pyrazoles Flavonones Pyrroline Chalcones Index. décimale : 540 Chimie et sciences connexes Permalink : index.php?lvl=notice_display&id=4057 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité KOU/3882 KOU/3882 Thèse Bibliothèque principale Thèses Disponible
Titre : Synthèse d'hétérocycles quinoléiques à visée thérapeutique et d'analogues structuraux de produits naturels Type de document : texte imprimé Auteurs : Abdelmalek Bouraiou ; Univ. de Constantine, Éditeur scientifique ; A. Belfaitah, Directeur de thèse Année de publication : 2009 Importance : 198 p. Note générale : 01 Disponible à la salle de recherche 02 Disponibles au magazin de la B.U.C. 01 CD Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Flavonoides Quinoléine Activité biologique Cycloaddition 1,3-dipolaire Ylure d'azométhine Aza-analogues Index. décimale : 540 Chimie et sciences connexes En ligne : ../theses/chimie/BOU5383.pdf Permalink : index.php?lvl=notice_display&id=3786 Synthèse d'hétérocycles quinoléiques à visée thérapeutique et d'analogues structuraux de produits naturels [texte imprimé] / Abdelmalek Bouraiou ; Univ. de Constantine, Éditeur scientifique ; A. Belfaitah, Directeur de thèse . - 2009 . - 198 p.
01 Disponible à la salle de recherche 02 Disponibles au magazin de la B.U.C. 01 CD
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Flavonoides Quinoléine Activité biologique Cycloaddition 1,3-dipolaire Ylure d'azométhine Aza-analogues Index. décimale : 540 Chimie et sciences connexes En ligne : ../theses/chimie/BOU5383.pdf Permalink : index.php?lvl=notice_display&id=3786 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité BOU/5383 BOU/5383 Thèse Bibliothèque principale Thèses Disponible
