1 résultat(s) recherche sur le tag 'Antioxidant enzymes'    

The effect of Argania spinosa on plasma Homocysteine, Lipids, Antioxidant enzymes and Aortas Sections in Methionine induced Hyperhomocysteinemia in mice / Badiaa Aklil  

Public ISBD Titre : The effect of Argania spinosa on plasma Homocysteine, Lipids, Antioxidant enzymes and Aortas Sections in Methionine induced Hyperhomocysteinemia in mice Type de document : texte imprimé Auteurs : Badiaa Aklil, Auteur ; Z. Kabouche, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2018 Importance : 150 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles Langues : Français (fre) Catégories : Français - Anglais Biologie Tags : Homocystéine  Argania spinosa  Antioxydant  Méthionine  Stress oxydant  Maladies ardiovasculaires  Biofilm  Homocysteine  Antioxidant enzymes  Methionine  Oxidative stress  Cardiovascular diseases  ?????????????  Argania spinosa????????? ??????? ???????  ????????  ??????? ????????  ????? ????? ???????? ???????  ????????? Index. décimale : 570 Sciences de la vie. Biologie Résumé : Hyperhomocysteinemia (HHcy), oxidative stress and decreased antioxidant capacities lead to several clinical manifestations and particularly, cardiovascular and liver diseases. In this study, we evaluated the protective and the preventive effect of the crude extract of Argania spinosa against HHcy ,hyperlipidemia, oxidant status and damages in the aorta, heart and liver induced by high L-methionine intake in mice. After 3 weeks of treatments, Hcy concentrations, lipid parameters, liver enzyme activities, hepatic antioxidant status and histological sections of aorta, liver and heart were determined. Our results showed that consumption of high L-methionine diet (500mg/Kg) led to an increase in plasma Hcy, CHO, LDL-c, TG, AST, corresponding with decrease of HDL-c, reduced GSH, and catalase activity. These were associated with the loss and degeneration of endothelium, fenestration and formation of foam cells in the media of the aorta, also the alteration of the cardiac muscle and liver tissue. However, the administration of the crude extract of A. spinosa (150mg/Kg) in combination with L-methionine ameliorated all these changes. Moreover, in the present thesis, we conducted a study in vitro to evaluate the antibacterial effect of Argan oil on biofilm formation. The results showed that there was a trend of increasing inhibition of 4 species of bacteria (Streptococcus mutans, Streptococcus anginosus, Streptococcus intermedius, and staphylococcus haemolyticus), that belong to gram positive strain as the Argan oil was getting more concentrated. Diplôme : Doctorat en sciences En ligne : ../theses/biologie/AKL7340.pdf Format de la ressource électronique : pdf Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10990 The effect of Argania spinosa on plasma Homocysteine, Lipids, Antioxidant enzymes and Aortas Sections in Methionine induced Hyperhomocysteinemia in mice [texte imprimé] / Badiaa Aklil, Auteur ; Z. Kabouche, Directeur de thèse . - [S.l.] : جامعة الإخوة منتوري قسنطينة, 2018 . - 150 f. ; 30 cm. 2 copies imprimées disponibles Langues : Français (fre) Catégories : Français - Anglais Biologie Tags : Homocystéine  Argania spinosa  Antioxydant  Méthionine  Stress oxydant  Maladies ardiovasculaires  Biofilm  Homocysteine  Antioxidant enzymes  Methionine  Oxidative stress  Cardiovascular diseases  ?????????????  Argania spinosa????????? ??????? ???????  ????????  ??????? ????????  ????? ????? ???????? ???????  ????????? Index. décimale : 570 Sciences de la vie. Biologie Résumé : Hyperhomocysteinemia (HHcy), oxidative stress and decreased antioxidant capacities lead to several clinical manifestations and particularly, cardiovascular and liver diseases. In this study, we evaluated the protective and the preventive effect of the crude extract of Argania spinosa against HHcy ,hyperlipidemia, oxidant status and damages in the aorta, heart and liver induced by high L-methionine intake in mice. After 3 weeks of treatments, Hcy concentrations, lipid parameters, liver enzyme activities, hepatic antioxidant status and histological sections of aorta, liver and heart were determined. Our results showed that consumption of high L-methionine diet (500mg/Kg) led to an increase in plasma Hcy, CHO, LDL-c, TG, AST, corresponding with decrease of HDL-c, reduced GSH, and catalase activity. These were associated with the loss and degeneration of endothelium, fenestration and formation of foam cells in the media of the aorta, also the alteration of the cardiac muscle and liver tissue. However, the administration of the crude extract of A. spinosa (150mg/Kg) in combination with L-methionine ameliorated all these changes. Moreover, in the present thesis, we conducted a study in vitro to evaluate the antibacterial effect of Argan oil on biofilm formation. The results showed that there was a trend of increasing inhibition of 4 species of bacteria (Streptococcus mutans, Streptococcus anginosus, Streptococcus intermedius, and staphylococcus haemolyticus), that belong to gram positive strain as the Argan oil was getting more concentrated. Diplôme : Doctorat en sciences En ligne : ../theses/biologie/AKL7340.pdf Format de la ressource électronique : pdf Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10990

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Code-barres	Cote	Support	Localisation	Section	Disponibilité
AKL/7340	AKL/7340	Thèse	Bibliothèque principale	Thèses	Disponible