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Titre : Etude des effets pharmaco toxicologieques de plantes médicinales d'Algérie : Activité cicatrisante et innocuité de l'huile végétale de Pistacia lentiscus L. Type de document : texte imprimé Auteurs : Zouhir Djerrou, Auteur ; Youcef Hamdi Pacha, Directeur de thèse Editeur : Constantine : Université Mentouri Constantine Année de publication : 2011 Importance : 135 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles Langues : Français (fre) Catégories : Français - Anglais
Sciences VétérinairesTags : Pistacia lentiscus L. vegetable oil dermal burns wound healing irritation toxicity hepato-renal function huile végétale brûlures cutanées cicatrisation toxicité, fonction hépatorénale زیت نباتي حروق الجلد التئام الجرح التهيّج السميّة الوظيفة الكبدیة الوظيفة الكلویة Index. décimale : 636 Sciences Vétérinaires Résumé :
Pistacia lentiscus L. is an evergreen shrub of 1 to 3 m high belonging to the family of Anacardiaceae. It is a traditional remedy which has been used by many ancient civilizations like Greeks and Egyptians. All parts of these plants have medicinal properties. However, the medicinal properties of vegetable oil extracted from fruits are particularly well known in North Africa, especially in the eastern region of Algeria to Tunisia. The inhabitants of these regions have used this oil for sore throat remedy, for treating skin burns and respiratory allergies.
The present work is a scientifc contribution to study some pharmacological and toxicological effects of this oil which kept our attention by its reputation in traditional medicine. The test of the Eye irritation / corrosion, showed that this oil is only slightly irritating to rabbit eye.
Similarly, the test of acute toxicity: Dermal irritation/corrosion allowed us to classify PLFO as slightly irritating to the skin, either intact or abraded. Repeated dermal toxicity test showed that this oil produced no edema, but a slight erythema was observed after the second week of application. This phenomenon is growing and regressing alternately until the end of the experiment, the latter does not exceed the rating of 2. One third of rabbits presented a phenomenon of local sensitization with skin thickening, which could reach 100% of the skin of the untreated regions. This phenomenon had been perfectly reversible and the skin has found its normal texture in a few days. As for the rectal route, the present oil was well tolerated. No anatomical or functional disturbance was observed in pathological examinations and histology. The biochemical parameters showed a significant decrease in AST and ALT
enzymes finding a positive impact of this oil on liver function. A significant increase in blood glucose, but still within the range of physiological norms, was recorded in suggesting a possible anti glycogenesis effect.
PLFO has also shown promising healing properties, this latter by reducing the inflammatory phase, stimulation of wound contraction and reducing the epithelization period.
The study concludes that Pistacia lentiscus fatty oil is effective for healing burns. It is tolerable in the short term, but may cause skin sensitization after prolonged use.Diplôme : Doctorat en sciences En ligne : ../theses/veterinaire/DJE6135.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=9532 Etude des effets pharmaco toxicologieques de plantes médicinales d'Algérie : Activité cicatrisante et innocuité de l'huile végétale de Pistacia lentiscus L. [texte imprimé] / Zouhir Djerrou, Auteur ; Youcef Hamdi Pacha, Directeur de thèse . - Constantine : Université Mentouri Constantine, 2011 . - 135 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
Sciences VétérinairesTags : Pistacia lentiscus L. vegetable oil dermal burns wound healing irritation toxicity hepato-renal function huile végétale brûlures cutanées cicatrisation toxicité, fonction hépatorénale زیت نباتي حروق الجلد التئام الجرح التهيّج السميّة الوظيفة الكبدیة الوظيفة الكلویة Index. décimale : 636 Sciences Vétérinaires Résumé :
Pistacia lentiscus L. is an evergreen shrub of 1 to 3 m high belonging to the family of Anacardiaceae. It is a traditional remedy which has been used by many ancient civilizations like Greeks and Egyptians. All parts of these plants have medicinal properties. However, the medicinal properties of vegetable oil extracted from fruits are particularly well known in North Africa, especially in the eastern region of Algeria to Tunisia. The inhabitants of these regions have used this oil for sore throat remedy, for treating skin burns and respiratory allergies.
The present work is a scientifc contribution to study some pharmacological and toxicological effects of this oil which kept our attention by its reputation in traditional medicine. The test of the Eye irritation / corrosion, showed that this oil is only slightly irritating to rabbit eye.
Similarly, the test of acute toxicity: Dermal irritation/corrosion allowed us to classify PLFO as slightly irritating to the skin, either intact or abraded. Repeated dermal toxicity test showed that this oil produced no edema, but a slight erythema was observed after the second week of application. This phenomenon is growing and regressing alternately until the end of the experiment, the latter does not exceed the rating of 2. One third of rabbits presented a phenomenon of local sensitization with skin thickening, which could reach 100% of the skin of the untreated regions. This phenomenon had been perfectly reversible and the skin has found its normal texture in a few days. As for the rectal route, the present oil was well tolerated. No anatomical or functional disturbance was observed in pathological examinations and histology. The biochemical parameters showed a significant decrease in AST and ALT
enzymes finding a positive impact of this oil on liver function. A significant increase in blood glucose, but still within the range of physiological norms, was recorded in suggesting a possible anti glycogenesis effect.
PLFO has also shown promising healing properties, this latter by reducing the inflammatory phase, stimulation of wound contraction and reducing the epithelization period.
The study concludes that Pistacia lentiscus fatty oil is effective for healing burns. It is tolerable in the short term, but may cause skin sensitization after prolonged use.Diplôme : Doctorat en sciences En ligne : ../theses/veterinaire/DJE6135.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=9532 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité DJE/6135 DJE/6135 Thèse Bibliothèque principale Thèses Disponible Documents numériques
texte intégraleAdobe Acrobat PDF"evaluation chimique et activite antidermatophyte de quelques plantes medicinales d’algerie " / Hadria Mansour Djaalab
Titre : "evaluation chimique et activite antidermatophyte de quelques plantes medicinales d’algerie " Type de document : texte imprimé Auteurs : Hadria Mansour Djaalab, Auteur ; Youcef Hamdi Pacha, Directeur de thèse Editeur : constantine [Algérie] : Université Constantine 1 Année de publication : 2014 Importance : 141 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
Sciences VétérinairesTags : "Lawsonia inermis L. Pistacia lentiscus L. Juglans regia L. activité antifongique CMI."
Lawsonia inermis L. antifungal activity, CMI.
"أوراق الحناء ، نبات الضرو، الجوز الملكي ؛ النشاط مضاد للفطريات ،
. CMI"Index. décimale : 636 Sciences Vétérinaires Résumé : "The use of plants or their extracts could be an excellent alternative to the problem of resistance to
antifungals. In view to find plant extracts with antidermatophytic activity, leaves of Lawsonia
inermis L., Pistacia lentiscus L. and bark of Juglans regia L., were soaked in ethanol. The
hydroalcoholic extracts were fractionated successively with petroleum ether, diethyl ether, ethyl
acetate and 1butanol. Extracts and fractions of the three plants were subjected to phytochemical
screening, by standard method, which has revealed their rich in flavonoids, tannins, sterols,
terpenoids and saponins.
Spectral analysis has shown molecules of nature: Flavonol, Flavone, Chalcone, Aurone or
Isoflavone present in all the extracts. By methods of incorporation in solid medium and broth
dilution, the evaluation of antidermatophyte activity was compared with that of Griseofulvin.
At a concentration of 35mg/ml, the three plants LIN, JRE and PLE have shown antifungal activity
against all of the selected strains.
The hydroalcoholic extract of Lawsonia inermis L. was the most active (P < 0.01) with an
inhibition diameter of 18.87 ± 0.58 mm and a MIC = 0.034 mg / ml for Candida albicans.
The extract of Pistcia lentiscus L. was the most active on Trichophyton mentagrophyte (P < 0.01)
by inducing an inhibition diameter of 17 ± 1.00 mm and a MIC = 0.068 mg / ml; Similarly, for
Microsporum canis (P < 0.01) with an inhibition zone of 16.67 ± 0.58 mm.
The extract of Juglans regia L. has developed a significant antifungal activity on Candida
albicans compared to other tested strains.
The antifungal effect of the three extracts on the Trichophyton rubrum strain has been
significantly comparable (P < 0.01).
Fractionation produced by FIFO with organic solvents of increasing polarity has not improved
antidermatophytic activity. Only Candida albicans was sensitive to tested phases of the extracts.
The results of this study justify the traditional use of the extracts of LIN, JRE and PLE in the
treatment of dermatoses and candidiasis. So these plants should be protected and valued."
Diplôme : Doctorat en sciences En ligne : ../theses/veterinaire/MAN6513.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=9627 "evaluation chimique et activite antidermatophyte de quelques plantes medicinales d’algerie " [texte imprimé] / Hadria Mansour Djaalab, Auteur ; Youcef Hamdi Pacha, Directeur de thèse . - constantine [Algérie] : Université Constantine 1, 2014 . - 141 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
Sciences VétérinairesTags : "Lawsonia inermis L. Pistacia lentiscus L. Juglans regia L. activité antifongique CMI."
Lawsonia inermis L. antifungal activity, CMI.
"أوراق الحناء ، نبات الضرو، الجوز الملكي ؛ النشاط مضاد للفطريات ،
. CMI"Index. décimale : 636 Sciences Vétérinaires Résumé : "The use of plants or their extracts could be an excellent alternative to the problem of resistance to
antifungals. In view to find plant extracts with antidermatophytic activity, leaves of Lawsonia
inermis L., Pistacia lentiscus L. and bark of Juglans regia L., were soaked in ethanol. The
hydroalcoholic extracts were fractionated successively with petroleum ether, diethyl ether, ethyl
acetate and 1butanol. Extracts and fractions of the three plants were subjected to phytochemical
screening, by standard method, which has revealed their rich in flavonoids, tannins, sterols,
terpenoids and saponins.
Spectral analysis has shown molecules of nature: Flavonol, Flavone, Chalcone, Aurone or
Isoflavone present in all the extracts. By methods of incorporation in solid medium and broth
dilution, the evaluation of antidermatophyte activity was compared with that of Griseofulvin.
At a concentration of 35mg/ml, the three plants LIN, JRE and PLE have shown antifungal activity
against all of the selected strains.
The hydroalcoholic extract of Lawsonia inermis L. was the most active (P < 0.01) with an
inhibition diameter of 18.87 ± 0.58 mm and a MIC = 0.034 mg / ml for Candida albicans.
The extract of Pistcia lentiscus L. was the most active on Trichophyton mentagrophyte (P < 0.01)
by inducing an inhibition diameter of 17 ± 1.00 mm and a MIC = 0.068 mg / ml; Similarly, for
Microsporum canis (P < 0.01) with an inhibition zone of 16.67 ± 0.58 mm.
The extract of Juglans regia L. has developed a significant antifungal activity on Candida
albicans compared to other tested strains.
The antifungal effect of the three extracts on the Trichophyton rubrum strain has been
significantly comparable (P < 0.01).
Fractionation produced by FIFO with organic solvents of increasing polarity has not improved
antidermatophytic activity. Only Candida albicans was sensitive to tested phases of the extracts.
The results of this study justify the traditional use of the extracts of LIN, JRE and PLE in the
treatment of dermatoses and candidiasis. So these plants should be protected and valued."
Diplôme : Doctorat en sciences En ligne : ../theses/veterinaire/MAN6513.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=9627 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité MAN/6513 MAN/6513 Thèse Bibliothèque principale Thèses Disponible
