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Partager le résultat de cette recherche Interroger des sources externesConception, caractérisation et application des complexes à base de ligands hétérocycliques / Feriel Aouatef Sahki ép Hammoudi
Titre : Conception, caractérisation et application des complexes à base de ligands hétérocycliques : azotés et soufrés. Type de document : texte imprimé Auteurs : Feriel Aouatef Sahki ép Hammoudi, Auteur ; Sofiane Bouacida, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2019 Importance : 207 f. Format : 30 cm. Note générale : Doctorat 3éme CYCLE LMD.
2 copies imprimées disponiblesLangues : Français (fre) Catégories : Français - Anglais
ChimieTags : Chimie: chimie inorganique Complexes de coordination Benzimidazole Quinoléine Benzothiazole Activité
antibactérienne Pouvoir antioxydant Structure électronique Surfaces d’Hirshfeld Coordination complexes Quinoline Antibacterial activity Antioxidant activity Electronic structure Hirshfeld Surfaces معقد تساندي كينولين بنزإميدازول بنزوثيازول نشاط مضاد للجراثيم نشاط مضاد للأكسدة البنية الالكترونية أسطح هيرشفيلدIndex. décimale : 540 Chimie et sciences connexes Résumé :
This work has been devoted to the design and characterization of some new heterocyclic nitrogen and sulfur donor ligands derived from quinoline, benz-imidazole and benzothiazole, as well as their coordination complexes. The evaluation of their antibacterial and antioxidant activity was also discussed. The 2-(1H-benzo[d]imidazol-2-yl) quinoline (BQ), 2-(((1-methyl-1H-imidazol-2- ylmethyl)sulfanyl)methyl)-1H-benzo[d]ligands imidazole (MIMTMB), 2-(((1-methyl-1Himidazol- 2-yl)methyl)sulfanyl)benzo[d]thiazole (MIMTBT), as well as two other ligands previously prepared in the laboratory: The bis((1H-benzo[d]imidazol-2-yl)methyl) sulfane (BBMS) and 2-((1H-benzo[d]imidazol-2-yl)methylthio)-1H-benzo[d]imidazole (BTMB) react with the chlorides of cobalt (II), zinc (II), manganese (II), mercury (II), lead (II), copper (II), and cadmium (II) to lead to coordination complexes. The structures of the ligands and their complexes have been elucidated by IR spectroscopy, 1H NMR, 13C NMR, UV-visible, elemental analysis and single-crystal X-ray diffraction. The structural characterization by RX revealed the complex environment and the stability of the crystal structure by hydrogen bonds and π-π interactions. Theoretical calculations for some complexes were made to understand the geometry and the electronic structure of some compounds. As well as thermogravimetric analyzes that have been performed on some compounds to better understand their behavior and thermal stability. The antibacterial activity of certain ligands and complexes was evaluated against three strains: Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. As well as an evaluation of their antioxidant activity (DPPH test).Note de contenu :
Annexes.Diplôme : Doctorat En ligne : ../theses/chimie/SAH7511.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11347 Conception, caractérisation et application des complexes à base de ligands hétérocycliques : azotés et soufrés. [texte imprimé] / Feriel Aouatef Sahki ép Hammoudi, Auteur ; Sofiane Bouacida, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2019 . - 207 f. ; 30 cm.
Doctorat 3éme CYCLE LMD.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Chimie: chimie inorganique Complexes de coordination Benzimidazole Quinoléine Benzothiazole Activité
antibactérienne Pouvoir antioxydant Structure électronique Surfaces d’Hirshfeld Coordination complexes Quinoline Antibacterial activity Antioxidant activity Electronic structure Hirshfeld Surfaces معقد تساندي كينولين بنزإميدازول بنزوثيازول نشاط مضاد للجراثيم نشاط مضاد للأكسدة البنية الالكترونية أسطح هيرشفيلدIndex. décimale : 540 Chimie et sciences connexes Résumé :
This work has been devoted to the design and characterization of some new heterocyclic nitrogen and sulfur donor ligands derived from quinoline, benz-imidazole and benzothiazole, as well as their coordination complexes. The evaluation of their antibacterial and antioxidant activity was also discussed. The 2-(1H-benzo[d]imidazol-2-yl) quinoline (BQ), 2-(((1-methyl-1H-imidazol-2- ylmethyl)sulfanyl)methyl)-1H-benzo[d]ligands imidazole (MIMTMB), 2-(((1-methyl-1Himidazol- 2-yl)methyl)sulfanyl)benzo[d]thiazole (MIMTBT), as well as two other ligands previously prepared in the laboratory: The bis((1H-benzo[d]imidazol-2-yl)methyl) sulfane (BBMS) and 2-((1H-benzo[d]imidazol-2-yl)methylthio)-1H-benzo[d]imidazole (BTMB) react with the chlorides of cobalt (II), zinc (II), manganese (II), mercury (II), lead (II), copper (II), and cadmium (II) to lead to coordination complexes. The structures of the ligands and their complexes have been elucidated by IR spectroscopy, 1H NMR, 13C NMR, UV-visible, elemental analysis and single-crystal X-ray diffraction. The structural characterization by RX revealed the complex environment and the stability of the crystal structure by hydrogen bonds and π-π interactions. Theoretical calculations for some complexes were made to understand the geometry and the electronic structure of some compounds. As well as thermogravimetric analyzes that have been performed on some compounds to better understand their behavior and thermal stability. The antibacterial activity of certain ligands and complexes was evaluated against three strains: Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. As well as an evaluation of their antioxidant activity (DPPH test).Note de contenu :
Annexes.Diplôme : Doctorat En ligne : ../theses/chimie/SAH7511.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11347 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité SAH/7511 SAH/7511 Thèse Bibliothèque principale Thèses Disponible
Titre : Métabolites secondaires et principes actifs : Détermination structurale de ces principaux composés naturels issus d’espèces endémiques de la région de Tébessa et de la Kabylie. Type de document : texte imprimé Auteurs : Redouane Lemoui, Auteur ; Samira Benyahia, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2018 Importance : 124 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Chimie organique: Phytochimie la Berberis hispanica la Stachys brachyclada flavonoïdes activité
antibactérienne l’activité antiproliférativeIndex. décimale : 540 Chimie et sciences connexes Résumé :
The present work focuses on a phytochemical and a biological study of two endemic Algerian species, Berberis hispanica from the family Berberidaceae and Stachys brachyclada from the family Lamiaceae. The phytochemical study of the ethyl acetate and n-butanol extracts of the aerial parts of the Berberis hispanica species has led to the isolation and identification of a phenolic acid, the first isolated caffeic acid in this species and two flavonoids: Tamarixetin; Rutin.The structural identification has been performed using spectroscopic analysis techniques (MS,1H NMR, 13C NMR), supported by a comparison with literature data. As for the biological study of AcOEt extracts, n-BuOH and flavonoid tamarixetin of this species, it has given interesting results. The n-BuOH extract has shown a better richness in polyphenols and flavonoids compared to the AcOET extract. The two extracts; AcOEt and n-BuOH have demonstrated a very good antibacterial activity with respect to the Klebsiella pneumonia strain (15 mm to 100 mg/ml). As for the antioxidant activity of these two extracts, it has been evaluated by the free radical scavenging method (DPPH) and has shown that the AcOEt extract (IC50 = 79,8μg/mL) has a better activity compared with the n-BuOH extract (IC50 = 136, 2 μg/ml). In addition, the antiproliferative activity of the flavonoid tamarixetin indicates a good response against HeLa cells (carcinoma of the human uterine cervix). Concerning the phytochemical study of the MeOH extract of the aerial parts of the second Stachysbrachyclada species, it has led to the separation and purification of five flavonoids isolated for the first time in the species, namely: Stachysetin ; Lutéoline-7-O- -D-allopyranosyl-(1→2)-glucopyranoside ; Isoscutellareine-7-O- -D-allopyranosyl-(1→2) glucopyranoside ; Apigénine ; Lutéoline.Their identification has been carried out by combining our spectroscopic data (MS, 1D and 2D NMR) with those of the literature.Note de contenu :
Annexe.
Diplôme : Doctorat en sciences En ligne : ../theses/chimie/LEM7464.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11295 Métabolites secondaires et principes actifs : Détermination structurale de ces principaux composés naturels issus d’espèces endémiques de la région de Tébessa et de la Kabylie. [texte imprimé] / Redouane Lemoui, Auteur ; Samira Benyahia, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2018 . - 124 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Chimie organique: Phytochimie la Berberis hispanica la Stachys brachyclada flavonoïdes activité
antibactérienne l’activité antiproliférativeIndex. décimale : 540 Chimie et sciences connexes Résumé :
The present work focuses on a phytochemical and a biological study of two endemic Algerian species, Berberis hispanica from the family Berberidaceae and Stachys brachyclada from the family Lamiaceae. The phytochemical study of the ethyl acetate and n-butanol extracts of the aerial parts of the Berberis hispanica species has led to the isolation and identification of a phenolic acid, the first isolated caffeic acid in this species and two flavonoids: Tamarixetin; Rutin.The structural identification has been performed using spectroscopic analysis techniques (MS,1H NMR, 13C NMR), supported by a comparison with literature data. As for the biological study of AcOEt extracts, n-BuOH and flavonoid tamarixetin of this species, it has given interesting results. The n-BuOH extract has shown a better richness in polyphenols and flavonoids compared to the AcOET extract. The two extracts; AcOEt and n-BuOH have demonstrated a very good antibacterial activity with respect to the Klebsiella pneumonia strain (15 mm to 100 mg/ml). As for the antioxidant activity of these two extracts, it has been evaluated by the free radical scavenging method (DPPH) and has shown that the AcOEt extract (IC50 = 79,8μg/mL) has a better activity compared with the n-BuOH extract (IC50 = 136, 2 μg/ml). In addition, the antiproliferative activity of the flavonoid tamarixetin indicates a good response against HeLa cells (carcinoma of the human uterine cervix). Concerning the phytochemical study of the MeOH extract of the aerial parts of the second Stachysbrachyclada species, it has led to the separation and purification of five flavonoids isolated for the first time in the species, namely: Stachysetin ; Lutéoline-7-O- -D-allopyranosyl-(1→2)-glucopyranoside ; Isoscutellareine-7-O- -D-allopyranosyl-(1→2) glucopyranoside ; Apigénine ; Lutéoline.Their identification has been carried out by combining our spectroscopic data (MS, 1D and 2D NMR) with those of the literature.Note de contenu :
Annexe.
Diplôme : Doctorat en sciences En ligne : ../theses/chimie/LEM7464.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11295 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité LEM/7464 LEM/7464 Thèse Bibliothèque principale Thèses Disponible
