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Titre : Diversité biologique dans les Triticum et Hordeum : possibilités de création d’une nouvelle variabilité génétique. Type de document : texte imprimé Auteurs : Chafia Zerafa, Auteur ; M Benlaribi, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2017 Importance : 182 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : Biological diversity Triticum Hordeum UPOV Genetic resource variability Index. décimale : 570 Sciences de la vie. Biologie Résumé : The aim of this study is to characterize and first express the biological diversity of a
number of the genotypes of the Triticum and Hordeum genus in order to know the basic traits
that can be exploited in the improvement of these cereals.
In this context 10 cultivars of hard wheat Triticum durum Desf., 6 of wheat Triticum
aestivum L. and 6 others of barley Hordeum vulgare L. have been experimented for several
successive years.
The cultivation is carried out in pots on agricultural soil and the tests are carried out in the
glasshouse of the biopole at Mentouri University under semi-controlled conditions.
Thus, a number of characteristics related to the vegetative apparatus, the reproductive
system and the grain are monitored throughout the life cycle of the plant that is to say from
seeding to Maturation of the caryopses.
In addition to the phenological aspects adopted by UPOV in the framework of the DSH and
expressed by the Soltner (1982 and 2005) model, the characterization concerned, in order to
determine relative precisely the duration of expression of each development phase, some
adaptation traits
A cross-breeding trial between varieties of each species is then taken in the second step
with the aim of creating variability.
The findings suggest a great intra and inter-specific biological diversity represented
particularly by certain basic characteristics such as precocity glaucescence and others relative
to the production.
They also reveal a wide variability in the heritage of available cereal genetic resources that
can be easily exploited in the creation of a new variety in wheat and barley.
This is demonstrated through our trial or hybrids are obtained by the approach pollinating
method.Diplôme : Doctorat en sciences En ligne : ../theses/biologie/ZER7108.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10493 Diversité biologique dans les Triticum et Hordeum : possibilités de création d’une nouvelle variabilité génétique. [texte imprimé] / Chafia Zerafa, Auteur ; M Benlaribi, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2017 . - 182 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Biological diversity Triticum Hordeum UPOV Genetic resource variability Index. décimale : 570 Sciences de la vie. Biologie Résumé : The aim of this study is to characterize and first express the biological diversity of a
number of the genotypes of the Triticum and Hordeum genus in order to know the basic traits
that can be exploited in the improvement of these cereals.
In this context 10 cultivars of hard wheat Triticum durum Desf., 6 of wheat Triticum
aestivum L. and 6 others of barley Hordeum vulgare L. have been experimented for several
successive years.
The cultivation is carried out in pots on agricultural soil and the tests are carried out in the
glasshouse of the biopole at Mentouri University under semi-controlled conditions.
Thus, a number of characteristics related to the vegetative apparatus, the reproductive
system and the grain are monitored throughout the life cycle of the plant that is to say from
seeding to Maturation of the caryopses.
In addition to the phenological aspects adopted by UPOV in the framework of the DSH and
expressed by the Soltner (1982 and 2005) model, the characterization concerned, in order to
determine relative precisely the duration of expression of each development phase, some
adaptation traits
A cross-breeding trial between varieties of each species is then taken in the second step
with the aim of creating variability.
The findings suggest a great intra and inter-specific biological diversity represented
particularly by certain basic characteristics such as precocity glaucescence and others relative
to the production.
They also reveal a wide variability in the heritage of available cereal genetic resources that
can be easily exploited in the creation of a new variety in wheat and barley.
This is demonstrated through our trial or hybrids are obtained by the approach pollinating
method.Diplôme : Doctorat en sciences En ligne : ../theses/biologie/ZER7108.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10493 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité ZER/7108 ZER/7108 Thèse Bibliothèque principale Thèses Disponible خصائص ل . U.P.O.Vوالتنوع عند الحبوب ذات السيقان التبنية) :(Triticum et Hordeumمحاولة خلق تنوعية جديدة / عواطف غناي
Titre : خصائص ل . U.P.O.Vوالتنوع عند الحبوب ذات السيقان التبنية) :(Triticum et Hordeumمحاولة خلق تنوعية جديدة Type de document : texte imprimé Auteurs : عواطف غناي, Auteur ; مصطفى بن لعريبي, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2019 Importance : 209 ورقة. Format : 30 سم. Note générale : Doctorat en 3 éme cycle LMD.
2نسخ موجودة مكتبة المركزية
Langues : Arabe (ara) Catégories : Arabe
5 البيولوجياTags : cumالتنوع التنوعية التصالب النصف تبادلي ASC AGCقوة الهجينالتقنيات الحيوية، البيولوجيا والمحيط: القواعد البيولوجية للإنتاج والتنوع الحيوي النباتي Triticum Hordeum Diversity Variability half dialel cross GCA SCA Heterosis Diversité Variabilité Croisement demi-diallèle AGC Hétérosis Index. décimale : 570 بيولوجيا Résumé : The main objective of our study, as stipulated in the title of the thesis, is to contribute methodologically to the creation of genetic variability while targeting the particular elements of parents, characters easy to distinguish in order to be able to observe them easily appear in the descendants. To do this, we started by characterizing the parental genotypes of the three species under study (T.durum Desf., T.aestivum L., H.vulgare L.) and by evaluating the morphophenological and physiological characters through the creation of descriptive sheets according to the recommendations of the U.P.O.V to know the amount of the genetic variability in order to choose the appropriate methods before to launch in improvement programs. The experiment was carried out in a glass greenhouse at the Bio-pôle of the Laboratory for the Development and Valorization of Plant Genetic Resources in Chaâb Erassas, University of the Mentouri brothers Constantine 1, for five seasons. The results obtained and related to the parents showed a significant difference between the genotypes of each species through the phenology, the descriptive sheets and the characters of production and adaptation. These results suggest that hybrids from these parents will be highly different from each other. Once this step is performed, A half-diallel crosses are undertaken between the parents judged to be better for creating a new variability and of proceed for the comparison the genetic potential of four (4) durum wheat cultivars, four (4) bread wheat and five (5) barley with their F1 hybrids as well as, the hybrid of second generation (F2) for durum wheat. The parental genotypes and their hybrids are then sown in a complete randomized blocks design with three repetitions in half-diallel following method 2 and Model 1 of Griffing (1956). The results of the first generation of each species indicated the importance of the additive and non-additive effects in the inheritance of traits under study with the preponderance of additive gene effects for the spike length with beards, the length of beard and the number of nodes per plant. The two effects of additive and nonadditive genes are equal to the of spike length in barley. The effects of additive genes were observed in heredity of the neck spike length, plant height, spike length with barbs, the length of beard, the number of spikelets per spike, the fertility of the spike and the number of grains per spike at common wheat, while controlling flag leaf area, spike length in the first generation of durum wheat and the number of nodes per plant in the second generation (F2). Non-additive gene effects were recorded for the rest of the traits studied. The parents Rihane 03 and Akhrash of barley, TSI \ VEE and Florence aurore of bread wheat and Djeneh - Khataifa, Guemgoum Rekham in durum wheat have recorded in F1the best significant values for general combining ability (GCA) for some characters of production and adaptation. The same observation was noted in F2 for the same genotypes of durum wheat. It is therefore suggested to use these parents in cereal breeding programs because of their ability to inherit these traits from to their descendants. Several hybrids record positive values of specific combining ability (SCA) due to additive X additive genetic interaction and present the highest values of heterosis in F1. These are the hybrids Akhrash x Beecher10, Jaidor x Akhrash in the barley, TSI \ VEE X Mexipak in bread wheat and Djeneh-Khetaifa x Guemgoum Rekham in durum wheat. The value of heterosis decreases certainly in F2, but remains in favor of the hybrid Djeneh –Khetaifa x Guemgoum Rekham. While the F2 generation of hybrids Béliouni x Guemgoum Rekham and Béliouni X Djeneh –Khetaifa are distinguished by the highest positive values of specific combining ability and a important heterosis effects. These hybrids can be adopted as new genotypes inheriting the traits of production and adaptation, hence the interest of continuing their selection in isolated generations to reach pure lines cultivated in fixed varieties. The study of heritability in the narrow sense showed strong values in half of the characters studied for barley and in thirteen (13) traits of common wheat and four (4) traits for durum wheat in the first generation and one trait for the second generation, while, heritability values in the broad sense are high for most traits studied in the three species. Keyword : Triticum, Hordeum, Diversity, Variability , half dialel cross, GCA, SCA, Heterosis. Diplôme : Doctorat En ligne : ../theses/biologie/AGHE4389.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11180 خصائص ل . U.P.O.Vوالتنوع عند الحبوب ذات السيقان التبنية) :(Triticum et Hordeumمحاولة خلق تنوعية جديدة [texte imprimé] / عواطف غناي, Auteur ; مصطفى بن لعريبي, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2019 . - 209 ورقة. ; 30 سم.
Doctorat en 3 éme cycle LMD.
2نسخ موجودة مكتبة المركزية
Langues : Arabe (ara)
Catégories : Arabe
5 البيولوجياTags : cumالتنوع التنوعية التصالب النصف تبادلي ASC AGCقوة الهجينالتقنيات الحيوية، البيولوجيا والمحيط: القواعد البيولوجية للإنتاج والتنوع الحيوي النباتي Triticum Hordeum Diversity Variability half dialel cross GCA SCA Heterosis Diversité Variabilité Croisement demi-diallèle AGC Hétérosis Index. décimale : 570 بيولوجيا Résumé : The main objective of our study, as stipulated in the title of the thesis, is to contribute methodologically to the creation of genetic variability while targeting the particular elements of parents, characters easy to distinguish in order to be able to observe them easily appear in the descendants. To do this, we started by characterizing the parental genotypes of the three species under study (T.durum Desf., T.aestivum L., H.vulgare L.) and by evaluating the morphophenological and physiological characters through the creation of descriptive sheets according to the recommendations of the U.P.O.V to know the amount of the genetic variability in order to choose the appropriate methods before to launch in improvement programs. The experiment was carried out in a glass greenhouse at the Bio-pôle of the Laboratory for the Development and Valorization of Plant Genetic Resources in Chaâb Erassas, University of the Mentouri brothers Constantine 1, for five seasons. The results obtained and related to the parents showed a significant difference between the genotypes of each species through the phenology, the descriptive sheets and the characters of production and adaptation. These results suggest that hybrids from these parents will be highly different from each other. Once this step is performed, A half-diallel crosses are undertaken between the parents judged to be better for creating a new variability and of proceed for the comparison the genetic potential of four (4) durum wheat cultivars, four (4) bread wheat and five (5) barley with their F1 hybrids as well as, the hybrid of second generation (F2) for durum wheat. The parental genotypes and their hybrids are then sown in a complete randomized blocks design with three repetitions in half-diallel following method 2 and Model 1 of Griffing (1956). The results of the first generation of each species indicated the importance of the additive and non-additive effects in the inheritance of traits under study with the preponderance of additive gene effects for the spike length with beards, the length of beard and the number of nodes per plant. The two effects of additive and nonadditive genes are equal to the of spike length in barley. The effects of additive genes were observed in heredity of the neck spike length, plant height, spike length with barbs, the length of beard, the number of spikelets per spike, the fertility of the spike and the number of grains per spike at common wheat, while controlling flag leaf area, spike length in the first generation of durum wheat and the number of nodes per plant in the second generation (F2). Non-additive gene effects were recorded for the rest of the traits studied. The parents Rihane 03 and Akhrash of barley, TSI \ VEE and Florence aurore of bread wheat and Djeneh - Khataifa, Guemgoum Rekham in durum wheat have recorded in F1the best significant values for general combining ability (GCA) for some characters of production and adaptation. The same observation was noted in F2 for the same genotypes of durum wheat. It is therefore suggested to use these parents in cereal breeding programs because of their ability to inherit these traits from to their descendants. Several hybrids record positive values of specific combining ability (SCA) due to additive X additive genetic interaction and present the highest values of heterosis in F1. These are the hybrids Akhrash x Beecher10, Jaidor x Akhrash in the barley, TSI \ VEE X Mexipak in bread wheat and Djeneh-Khetaifa x Guemgoum Rekham in durum wheat. The value of heterosis decreases certainly in F2, but remains in favor of the hybrid Djeneh –Khetaifa x Guemgoum Rekham. While the F2 generation of hybrids Béliouni x Guemgoum Rekham and Béliouni X Djeneh –Khetaifa are distinguished by the highest positive values of specific combining ability and a important heterosis effects. These hybrids can be adopted as new genotypes inheriting the traits of production and adaptation, hence the interest of continuing their selection in isolated generations to reach pure lines cultivated in fixed varieties. The study of heritability in the narrow sense showed strong values in half of the characters studied for barley and in thirteen (13) traits of common wheat and four (4) traits for durum wheat in the first generation and one trait for the second generation, while, heritability values in the broad sense are high for most traits studied in the three species. Keyword : Triticum, Hordeum, Diversity, Variability , half dialel cross, GCA, SCA, Heterosis. Diplôme : Doctorat En ligne : ../theses/biologie/AGHE4389.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11180 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité غنا/4389 غنا/4389 Thèse Bibliothèque principale Thèses Disponible
Titre : Cartographie de la variabilité thermique des écosystèmes forestiers de l’Est algérien. Type de document : texte imprimé Auteurs : Ahmed Laala, Auteur ; Djamel Alatou, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2016 Importance : 212 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : Ecologie végétale:Ecophysiologie et biotechnologie végétale Variabilité Température Forêt NDVI SIG MODIS Est algérien Cartographie Variability Temperature Forest GIS , Eastern Algeria Cartography التغيرات الحرارة الغابة مؤشر الغطاء النباتي الخضري نظام المعلومات الجغرافي القمر الصناعي MODIS شرق الجزائر رسم الخرائط Index. décimale : 570 Sciences de la vie. Biologie Résumé : Algerian forest patrimony is estimated at 4 million hectares, including forests, Scrub and brush. This forest is exposed to natural and anthropogenic hazards that cause severe degradation resulting mainly in continued regressive evolution and a ubstantial loss of wealth. Among the natural threats is the climate conditions and particularly the temperature of the environment in which forest ecosystems evolve. In addition to its action on life processes, on growth and on phenology of species, temperature can change also the biogeographic areas of ecosystems.
In this study we analyzed the temperature to characterize the thermal environment of
eastern Algeria and the effects of its variation on the dynamics and photosynthetic activity of forest ecosystems in this vast area. The used data is the temperatures for a period of 30 consecutive years (1982-2011) and spectral index (NDVI) which can detect the photosynthetic signal above the canopy.
Statistical analysis of long temperature series reveals that the warming observed
worldwide is already noticed in eastern Algeria. The majority of the wilayas exposed to this hazard, where the trend is more pronounced for the annual maximum temperature, may reach 3 °C/30years, an increase of 0.1C°/year. Thus, the estimate of thermal field for each pixel in eastern Algeria was realized by using Geostatistical methods based on multiple regression between temperature and the explanatory variables describing the relief. From these spatial data, the thermal limits have been defined for each forest species. Finally, the technical of GIS and satellite images allowed us to monitor the dynamics of forest vegetation, and to build maps that define the relationship between forest biomass and thermal parameters. These maps helped us to
identify 901087 hectares where trees were very sensitive to changes in the average temperature, with a percentage of 53.9% of the total area of the studied forest ecosystems. Thus, the minimum temperature affects photosynthesis of forest species in an area of 852406 ha with 50.8% of the total forest area. This cartographic expression is effective, firstly for forestry in the discrimination of forest plots where the thermal factor is the limiting factor of productivity and secondly for decision makers to define the forest management strategies of country.
Diplôme : Doctorat en sciences En ligne : ../theses/biologie/LAA6983.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10412 Cartographie de la variabilité thermique des écosystèmes forestiers de l’Est algérien. [texte imprimé] / Ahmed Laala, Auteur ; Djamel Alatou, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2016 . - 212 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Ecologie végétale:Ecophysiologie et biotechnologie végétale Variabilité Température Forêt NDVI SIG MODIS Est algérien Cartographie Variability Temperature Forest GIS , Eastern Algeria Cartography التغيرات الحرارة الغابة مؤشر الغطاء النباتي الخضري نظام المعلومات الجغرافي القمر الصناعي MODIS شرق الجزائر رسم الخرائط Index. décimale : 570 Sciences de la vie. Biologie Résumé : Algerian forest patrimony is estimated at 4 million hectares, including forests, Scrub and brush. This forest is exposed to natural and anthropogenic hazards that cause severe degradation resulting mainly in continued regressive evolution and a ubstantial loss of wealth. Among the natural threats is the climate conditions and particularly the temperature of the environment in which forest ecosystems evolve. In addition to its action on life processes, on growth and on phenology of species, temperature can change also the biogeographic areas of ecosystems.
In this study we analyzed the temperature to characterize the thermal environment of
eastern Algeria and the effects of its variation on the dynamics and photosynthetic activity of forest ecosystems in this vast area. The used data is the temperatures for a period of 30 consecutive years (1982-2011) and spectral index (NDVI) which can detect the photosynthetic signal above the canopy.
Statistical analysis of long temperature series reveals that the warming observed
worldwide is already noticed in eastern Algeria. The majority of the wilayas exposed to this hazard, where the trend is more pronounced for the annual maximum temperature, may reach 3 °C/30years, an increase of 0.1C°/year. Thus, the estimate of thermal field for each pixel in eastern Algeria was realized by using Geostatistical methods based on multiple regression between temperature and the explanatory variables describing the relief. From these spatial data, the thermal limits have been defined for each forest species. Finally, the technical of GIS and satellite images allowed us to monitor the dynamics of forest vegetation, and to build maps that define the relationship between forest biomass and thermal parameters. These maps helped us to
identify 901087 hectares where trees were very sensitive to changes in the average temperature, with a percentage of 53.9% of the total area of the studied forest ecosystems. Thus, the minimum temperature affects photosynthesis of forest species in an area of 852406 ha with 50.8% of the total forest area. This cartographic expression is effective, firstly for forestry in the discrimination of forest plots where the thermal factor is the limiting factor of productivity and secondly for decision makers to define the forest management strategies of country.
Diplôme : Doctorat en sciences En ligne : ../theses/biologie/LAA6983.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10412 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité LAA/6983 LAA/6983 Thèse Bibliothèque principale Thèses Disponible
Titre : Etude et conception d’antennes à résonateurs diélectriques : Application à la réalisation d’une antenne reconfigurable Type de document : texte imprimé Auteurs : Abla Behloul èp Bachkhaznadji, Auteur ; Abdelmadjid Benghalia, Directeur de thèse ; Tayeb A Denidni, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2017 Importance : 100 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ElectroniqueTags : Antennes à résonateur diélectrique méthode des différences finies dans le
domaine temporel (FDTD) effet de couplage antenne reconfigurable en diagramme de
rayonnement Variability Temperature Forest NDVI GIS MODIS Eastern Algeria Cartography هوائي رو رنان عازل طريقة الفروق المحذودة في المجال انسمني (FDTD) هوائي اعادة تشكيم نمط
الاشعاع و تاثير الاقترانIndex. décimale : 621 Electronique Résumé : This work consists of a contribution to the modeling and the conception of dielectric resonator
antennas with application to the realization of reconfigurable antenna. The dielectric resonator
antennas are important antenna for the flexibility and the ease of integration in wireless
systems (WLAN), where they allow to use several shapes (rectangular, triangular,etc) and
several power supplies (coupling slot, coaxial cable,etc.). We are also interested by the
coupling effect due to the presence of another antenna or a presence of a coupling slot. The
calculated program based on the FDTD method to modeling a dielectric resonator antenna, we
enable to calculate the reflection coefficient, the input impedance electrical and the magnetic
fields. The HFSS simulator is used to validate these results. Then, this study has been
extended to the conception and the fabrication of a reconfigurable dielectric resonator
antenna. For this purpose, we studied and simulated a reconfigurable antenna structure by
using two simulator (HFSS, CST), then we proposed another structure which is a triangular
reconfigurable dielectric resonator antenna simulated by CST simulator and fabricated in RF
laboratory, of the National Institute of Scientific Research, INRS, Canada. The numerical
results are presented in terms of the reflection coefficient, radiation pattern, gain, and
efficiency. In addition, we have studied an dielectric resonator antenna with reconfigurable by
diodes PIN. Two distinct radiation patterns were obtained by maintaining the same resonance
frequency, which shows that the insertion of electrically-driven semiconductor components
into the antenna base structure provides an effective means for reconfigurability of the
radiation
Diplôme : Doctorat en sciences En ligne : ../theses/electronique/BEH7084.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10517 Etude et conception d’antennes à résonateurs diélectriques : Application à la réalisation d’une antenne reconfigurable [texte imprimé] / Abla Behloul èp Bachkhaznadji, Auteur ; Abdelmadjid Benghalia, Directeur de thèse ; Tayeb A Denidni, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2017 . - 100 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ElectroniqueTags : Antennes à résonateur diélectrique méthode des différences finies dans le
domaine temporel (FDTD) effet de couplage antenne reconfigurable en diagramme de
rayonnement Variability Temperature Forest NDVI GIS MODIS Eastern Algeria Cartography هوائي رو رنان عازل طريقة الفروق المحذودة في المجال انسمني (FDTD) هوائي اعادة تشكيم نمط
الاشعاع و تاثير الاقترانIndex. décimale : 621 Electronique Résumé : This work consists of a contribution to the modeling and the conception of dielectric resonator
antennas with application to the realization of reconfigurable antenna. The dielectric resonator
antennas are important antenna for the flexibility and the ease of integration in wireless
systems (WLAN), where they allow to use several shapes (rectangular, triangular,etc) and
several power supplies (coupling slot, coaxial cable,etc.). We are also interested by the
coupling effect due to the presence of another antenna or a presence of a coupling slot. The
calculated program based on the FDTD method to modeling a dielectric resonator antenna, we
enable to calculate the reflection coefficient, the input impedance electrical and the magnetic
fields. The HFSS simulator is used to validate these results. Then, this study has been
extended to the conception and the fabrication of a reconfigurable dielectric resonator
antenna. For this purpose, we studied and simulated a reconfigurable antenna structure by
using two simulator (HFSS, CST), then we proposed another structure which is a triangular
reconfigurable dielectric resonator antenna simulated by CST simulator and fabricated in RF
laboratory, of the National Institute of Scientific Research, INRS, Canada. The numerical
results are presented in terms of the reflection coefficient, radiation pattern, gain, and
efficiency. In addition, we have studied an dielectric resonator antenna with reconfigurable by
diodes PIN. Two distinct radiation patterns were obtained by maintaining the same resonance
frequency, which shows that the insertion of electrically-driven semiconductor components
into the antenna base structure provides an effective means for reconfigurability of the
radiation
Diplôme : Doctorat en sciences En ligne : ../theses/electronique/BEH7084.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10517 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité BEH/7084 BEH/7084 Thèse Bibliothèque principale Thèses Disponible
Titre : Étude des gènes de prédisposition aux cancers colorectaux : Syndrome de Lynch Type de document : texte imprimé Auteurs : Hedia Ziada-Bouchaar, Auteur ; Nourredine Abadi, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2017 Importance : 157 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : Familles algériennes HNPCC Syndrome de Lynch MLH1 MSH2 gènes MMR Variability Temperature Forest , NDVI GIS MODIS Eastern Algeria Cartography العائلات الجزائرية السرطان القولوني المستقيمي الوراثي بدون زوائد متلازمة لينش MLH1و MMR Index. décimale : 570 Sciences de la vie. Biologie Résumé : Colorectal cancer (CRC) is currently a major public health problem in Algeria.
Among the hereditary forms of this cancer, Hereditary Non-Polyposis Colorectal Cancer
(HNPCC) is an autosomal dominant disorder characterized by the early onset of CRC. This
syndrome is linked to germline defects in Mismatch Repair (MMR) genes. The work we have
done has been devoted to studying the molecular correlation between CRC and mutations
occurring in the MLH1, MSH2 and MSH6 repair genes in 27 unrelated Algerian families.
The search for germline mutations was tested by sequencing all exons and adjacent
intronic sequences. Multiplex ligand-dependent probe amplification (MLPA) technique was
used for testing large genomic rearrangements (deletion / duplication), when we observed no
point mutations.
Pathogenic mutations were identified in 15 % of families with clinical suspicion on
HNPCC. Two novel variants described for the first time in Algerian families were identified
in MLH1, c.881_884delTCAGinsCATTCCT and a large deletion in MSH6 gene from a young
onset of CRC. Moreover, the variants of MSH2 gene: c.942+3A>T et c.1030C>T, the most
described ones, were also detected in our families. Furthermore, the families HNPCC caused
by MSH6 germline mutation may show an age of onset that is comparable to this of patients
with MLH1 and MSH2 mutations.
According to our results, we confirmed that MSH2, MLH1, and MSH6 contribute to
CRC susceptibility. This work represents the implementation of a diagnostic algorithm for the
identification of Lynch syndrome patients in Algerian families, which can assist in the
management of these patients and the medical supervision of their relatives at risk.
Diplôme : Doctorat en sciences En ligne : ../theses/biologie/ZIA7080.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10521 Étude des gènes de prédisposition aux cancers colorectaux : Syndrome de Lynch [texte imprimé] / Hedia Ziada-Bouchaar, Auteur ; Nourredine Abadi, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2017 . - 157 f. ; 30 cm.
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Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Familles algériennes HNPCC Syndrome de Lynch MLH1 MSH2 gènes MMR Variability Temperature Forest , NDVI GIS MODIS Eastern Algeria Cartography العائلات الجزائرية السرطان القولوني المستقيمي الوراثي بدون زوائد متلازمة لينش MLH1و MMR Index. décimale : 570 Sciences de la vie. Biologie Résumé : Colorectal cancer (CRC) is currently a major public health problem in Algeria.
Among the hereditary forms of this cancer, Hereditary Non-Polyposis Colorectal Cancer
(HNPCC) is an autosomal dominant disorder characterized by the early onset of CRC. This
syndrome is linked to germline defects in Mismatch Repair (MMR) genes. The work we have
done has been devoted to studying the molecular correlation between CRC and mutations
occurring in the MLH1, MSH2 and MSH6 repair genes in 27 unrelated Algerian families.
The search for germline mutations was tested by sequencing all exons and adjacent
intronic sequences. Multiplex ligand-dependent probe amplification (MLPA) technique was
used for testing large genomic rearrangements (deletion / duplication), when we observed no
point mutations.
Pathogenic mutations were identified in 15 % of families with clinical suspicion on
HNPCC. Two novel variants described for the first time in Algerian families were identified
in MLH1, c.881_884delTCAGinsCATTCCT and a large deletion in MSH6 gene from a young
onset of CRC. Moreover, the variants of MSH2 gene: c.942+3A>T et c.1030C>T, the most
described ones, were also detected in our families. Furthermore, the families HNPCC caused
by MSH6 germline mutation may show an age of onset that is comparable to this of patients
with MLH1 and MSH2 mutations.
According to our results, we confirmed that MSH2, MLH1, and MSH6 contribute to
CRC susceptibility. This work represents the implementation of a diagnostic algorithm for the
identification of Lynch syndrome patients in Algerian families, which can assist in the
management of these patients and the medical supervision of their relatives at risk.
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Code-barres Cote Support Localisation Section Disponibilité ZIA/7080 ZIA/7080 Thèse Bibliothèque principale Thèses Disponible 
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