| Titre : |
Synthèse et caractérisation de poly-hétérocycles bioactifs |
| Type de document : |
texte imprimé |
| Auteurs : |
Chamseddine Derabli, Auteur ; Raouf Boulcina, Directeur de thèse |
| Editeur : |
جامعة الإخوة منتوري قسنطينة |
| Année de publication : |
2016 |
| Importance : |
217 f. |
| Format : |
30 cm. |
| Note générale : |
2 copies imprimées disponibles
|
| Langues : |
Français (fre) |
| Catégories : |
Français - Anglais
Chimie
|
| Tags : |
Quinolones cyclisation d’aza-Michael liquides ioniques quinazolines quinazolinones quinoléines pyranopyrazoles pyrimidines Tacrine Maladie d’Alzheimer aza-Michael cyclization ionic liquids quinolines Alzheimer's disease الكينولونات تحلق آزا-ميكائيل السائل الأيوني كينازولينات كينازولينونات كينولين بيرانوبيرازول بيريميدين تاكرين مرض
الألزهايمر |
| Index. décimale : |
540 Chimie et sciences connexes |
| Résumé : |
This manuscript includes three main parts:
In the first chapter, we described a new method for preparation of 2-aryl-2,3-dihydro-4-quinolonesby the use of the cyclization of the corresponding 2-aminochalconesvia an azaMichael reaction. This method was catalyzed by a DABCO’s ionic liquid which allowed us to obtain quantitatively our intended products in a single step.
In the second chapter, we synthesized a series of new 1,2-dihydroquinazoline derivatives by a one pot reaction, from benzaldehyde derivatives, ammonium acetate and 2-aminobenzophenones in the presence of DMAP. Similarly, we described the synthesis of new hybrid quinazoline-quinoline compounds from raw materials and other easily accessible key intermediates.
Finally, the study that we have undertaken in this final chapter of the thesis has as main objective, the preparation of novel heterocyclic analogues of Tacrine (used in the treatment of Alzheimer's disease) based pyranopyrazole and pyrimidine structures.
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| Diplôme : |
Doctorat |
| Permalink : |
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Synthèse et caractérisation de poly-hétérocycles bioactifs
