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Auteur Hanane Achoub |
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Titre : Etude phytochimique et biologique de deux plantes médicinales Algériennes : Thymus ciliatus (Desf) (Lamiaceae) et Asteriscus graveolens (Forsk.) Dc. (Asteraceae). Type de document : texte imprimé Auteurs : Hanane Achoub, Auteur ; Lahcene Zaiter, Directeur de thèse Mention d'édition : 30/11/2020 Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2020 Importance : 267 f. Format : 30 cm. Note générale : 1 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Chimie organique: Phytochimie Thymus ciliatus (Desf) Asteriscus graveolens (Forsk.) dc. Lamiaceae Asteraceae sesquiterpènes flavonoïdes composés phénoliques monoterpènes activité antioxydante huile essentielle cytotoxicité sesquiterpenes flavonoids phenolic compounds monoterpenes Antioxidant activity essential oil cytotoxic effect سسكويثربينات فلافونويد مركبات فينولية أحادية التربينات نشاط مضادات الأكسدة الزيت الأساسي تأثير السمي للخلايا Index. décimale : 540 Chimie et sciences connexes Résumé :
This work concerned the phytochemical and biological study of two Algerian medicinal plants Thymus ciliatus (Desf) and Asteriscus graveolens (Forsk.) dc. belonging to the families Lamiaceae and Asteraceae ,respectively. This study led to the isolation of twenty seven products from which seventeen were identified including. Among the isolated compounds, 5 sesquiterpenes from which 3 were new, 6 flavonoids which 1 is new, 4 phenolic compounds and 2 monoterpenes. The structures of the isolated products were elucidated mainly by the combination of spectroscopic methods mainly: NMR techniques (1H, 13C, COSY, HSQC and HMBC), UV spectrophotometry, we also used high resolution mass spectrometry methods and comparison with literature data. The quantification of total phenols and total flavonoids contents of the EtOAc, nBuOH extracts of the aerial parts of Thymus ciliatus (Desf) were determined, EtOAc extract had the highest phenolic and flavonoid contents followed by n-butanol extract. This extracts showed an excellent antioxidant activity by DPPH test. The antioxidant activity of AcOEt and n-BuOH extracts of Asteriscus graveolens was estimated by the DPPH test and β-Carotene bleaching assay. The best result was obtained for the ethyl acetate extract, especially in the DPPH method, where its effect is greater than BHT and α-tocopherol used as standards. Both extracts and some isolated compounds of Asteriscus graveolens were tested for their cytotoxic effect in human cancer cell lines (HCT-116, DLD1 and HDFa). The results indicate that EtOAc extract and isolated compounds 9 α-hydroxyparthenolide, 9β-hydroxyparthenolide et 7,12-dihydroxy-6,7- dihydro-5,(6) E-dehydronerolidol showed significant activity compared to the n-BuOH extract and and the two new compounds. The chemical composition of the essential oil of aerial parts of Thymus ciliatus (Desf) Benth studied by GC-FID and GC-MS showed that this oil is mainly composed of elemol (6.80%), carvacrol (5.86%), γ-muurolene (5.18%), β-sesquiphellandrene (5.09%), bicyclogermacrene (5.04%), β-Pinene (4.49%) and curcumene (4.20%).Note de contenu : Annexes. Diplôme : Doctorat en sciences En ligne : ../theses/chimie/ACH7683.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11517 Etude phytochimique et biologique de deux plantes médicinales Algériennes : Thymus ciliatus (Desf) (Lamiaceae) et Asteriscus graveolens (Forsk.) Dc. (Asteraceae). [texte imprimé] / Hanane Achoub, Auteur ; Lahcene Zaiter, Directeur de thèse . - 30/11/2020 . - جامعة الإخوة منتوري قسنطينة, 2020 . - 267 f. ; 30 cm.
1 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Chimie organique: Phytochimie Thymus ciliatus (Desf) Asteriscus graveolens (Forsk.) dc. Lamiaceae Asteraceae sesquiterpènes flavonoïdes composés phénoliques monoterpènes activité antioxydante huile essentielle cytotoxicité sesquiterpenes flavonoids phenolic compounds monoterpenes Antioxidant activity essential oil cytotoxic effect سسكويثربينات فلافونويد مركبات فينولية أحادية التربينات نشاط مضادات الأكسدة الزيت الأساسي تأثير السمي للخلايا Index. décimale : 540 Chimie et sciences connexes Résumé :
This work concerned the phytochemical and biological study of two Algerian medicinal plants Thymus ciliatus (Desf) and Asteriscus graveolens (Forsk.) dc. belonging to the families Lamiaceae and Asteraceae ,respectively. This study led to the isolation of twenty seven products from which seventeen were identified including. Among the isolated compounds, 5 sesquiterpenes from which 3 were new, 6 flavonoids which 1 is new, 4 phenolic compounds and 2 monoterpenes. The structures of the isolated products were elucidated mainly by the combination of spectroscopic methods mainly: NMR techniques (1H, 13C, COSY, HSQC and HMBC), UV spectrophotometry, we also used high resolution mass spectrometry methods and comparison with literature data. The quantification of total phenols and total flavonoids contents of the EtOAc, nBuOH extracts of the aerial parts of Thymus ciliatus (Desf) were determined, EtOAc extract had the highest phenolic and flavonoid contents followed by n-butanol extract. This extracts showed an excellent antioxidant activity by DPPH test. The antioxidant activity of AcOEt and n-BuOH extracts of Asteriscus graveolens was estimated by the DPPH test and β-Carotene bleaching assay. The best result was obtained for the ethyl acetate extract, especially in the DPPH method, where its effect is greater than BHT and α-tocopherol used as standards. Both extracts and some isolated compounds of Asteriscus graveolens were tested for their cytotoxic effect in human cancer cell lines (HCT-116, DLD1 and HDFa). The results indicate that EtOAc extract and isolated compounds 9 α-hydroxyparthenolide, 9β-hydroxyparthenolide et 7,12-dihydroxy-6,7- dihydro-5,(6) E-dehydronerolidol showed significant activity compared to the n-BuOH extract and and the two new compounds. The chemical composition of the essential oil of aerial parts of Thymus ciliatus (Desf) Benth studied by GC-FID and GC-MS showed that this oil is mainly composed of elemol (6.80%), carvacrol (5.86%), γ-muurolene (5.18%), β-sesquiphellandrene (5.09%), bicyclogermacrene (5.04%), β-Pinene (4.49%) and curcumene (4.20%).Note de contenu : Annexes. Diplôme : Doctorat en sciences En ligne : ../theses/chimie/ACH7683.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11517 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité ACHO/7683 ACHO/7683 Thèse Bibliothèque principale Thèses Disponible Recherche et détermination structurale de métabolites secondaires de Matricaria Chamomilla (Asteraceae) / Hanane Achoub
Titre : Recherche et détermination structurale de métabolites secondaires de Matricaria Chamomilla (Asteraceae) : Etude de la phase n- butanol. Type de document : texte imprimé Auteurs : Hanane Achoub, Auteur ; Lahcene Zaiter, Directeur de thèse Editeur : constantine [Algérie] : Université Constantine 1 Année de publication : 2013 Importance : 115 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Flavonoïdes matricaria chamomilla composées flavonoids Asteraceae العائلة المركبة الفلافونيدية Index. décimale : 540 Chimie et sciences connexes Résumé :
The main purpose in this work was, the isolation and the structural détermination of the secondary metabolites of the flavonoids type from the nbutanol phase of the aerial parts of Matricaria chamomilla species belonging to the Asteraceae family.
Our choice for this species is justified by the fact that several species of the geans Matricaria are used in folk medicine for their anti-inflammatory, antibacterial, anti-ulcerative , antipyretic ,antispasmodic activities, for treatment of gastrointestinal disorders and against uterine shrinkages…
This study relates to the phytochemical investigation of the n-butanol phase of the aqueous-alcoholic extracts of the leaves and the flowers of Matricaria chamomilla. This contribution led to the isolation of seven products in the pure state, from which, we have established the structure of to products.
- Luteolin-7-O-β-glucoside.
- 5, 6, 7,3’,4’-pentahydroxyflavone-4’-O-β-D-glucoside.
The isolation and structure determenation of isolated coumpounds were based on the different spectroscopic technics such as ultraviolet, 1H NMR, 13C NMR, 2D NMR experiments (COSY, HSQC, HMBC) and mass spectrometry.
It is important to note, that 5, 6, 7, 3’,4’-pentahydroxyflavone-4’-O-β-Dglucoside is new and then ,was not described elsewhere.Diplôme : Magistère En ligne : ../theses/chimie/ACH6327.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=6294 Recherche et détermination structurale de métabolites secondaires de Matricaria Chamomilla (Asteraceae) : Etude de la phase n- butanol. [texte imprimé] / Hanane Achoub, Auteur ; Lahcene Zaiter, Directeur de thèse . - constantine [Algérie] : Université Constantine 1, 2013 . - 115 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Flavonoïdes matricaria chamomilla composées flavonoids Asteraceae العائلة المركبة الفلافونيدية Index. décimale : 540 Chimie et sciences connexes Résumé :
The main purpose in this work was, the isolation and the structural détermination of the secondary metabolites of the flavonoids type from the nbutanol phase of the aerial parts of Matricaria chamomilla species belonging to the Asteraceae family.
Our choice for this species is justified by the fact that several species of the geans Matricaria are used in folk medicine for their anti-inflammatory, antibacterial, anti-ulcerative , antipyretic ,antispasmodic activities, for treatment of gastrointestinal disorders and against uterine shrinkages…
This study relates to the phytochemical investigation of the n-butanol phase of the aqueous-alcoholic extracts of the leaves and the flowers of Matricaria chamomilla. This contribution led to the isolation of seven products in the pure state, from which, we have established the structure of to products.
- Luteolin-7-O-β-glucoside.
- 5, 6, 7,3’,4’-pentahydroxyflavone-4’-O-β-D-glucoside.
The isolation and structure determenation of isolated coumpounds were based on the different spectroscopic technics such as ultraviolet, 1H NMR, 13C NMR, 2D NMR experiments (COSY, HSQC, HMBC) and mass spectrometry.
It is important to note, that 5, 6, 7, 3’,4’-pentahydroxyflavone-4’-O-β-Dglucoside is new and then ,was not described elsewhere.Diplôme : Magistère En ligne : ../theses/chimie/ACH6327.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=6294 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité ACH/6327 ACH/6327 Thèse Bibliothèque principale Thèses Disponible
