Détail de l'auteur
Auteur Taoues Boumoud |
Documents disponibles écrits par cet auteur (3)
Affiner la recherche Interroger des sources externesÉlaboration de nouvelles voies catalytiques dans la synthese de molécules hétérocycliques / Faiza Boukezzoula
Titre : Élaboration de nouvelles voies catalytiques dans la synthese de molécules hétérocycliques Type de document : texte imprimé Auteurs : Faiza Boukezzoula, Auteur ; Taoues Boumoud, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2016 Importance : 196 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : hétérocycles synthèse convergente réactions à composants multiples catalyse
organique molécules chirales et achirales synthèse asymétrique liquides ioniques pyrazolopyranopyrimidines pyranopyrazoles spirooxindoles heterocyclic compounds convergent strategy MCRs Organocatalysis asymmetrical and symmetrical molecules asymmetric synthesis ionic liquids المركبات الحلقية الغير متجانسة التفاعلات الكيماوية المتعددة المتفاعلات المحفزات العضوية المركبات الكيرالية ولاكيرالية السوائل الأيونية بيرازولوبيرانوابيرميدين بيرنوابيرازول سبيروا اكسندولIndex. décimale : 540 Chimie et sciences connexes Résumé : The subject that we developed "Elaboration of novel catalytic methods for the synthesis of
heterocyclic molecules " summarizes:
- Through a bibliographical study which puts forward the heterocyclic compounds, the advantage of the reactions making their synthesis possible, in occurrence MCRs and the privilege of organic catalysis.
- Through a study of the catalytic properties of two molecules asymmetrical (DMAP and DABCO) and two symmetrical (L-Proline and Cinchonine) with respect to the synthesis of
pyrazolpyrnopyrimidindiones/ones and pyranopyrazoles, via multicomponent reactions
- Through a study of catalytic properties of two ionic liquids [MePPh3][Br] and [OPPh3][Br] in the synthesis of the spirooxindoles and the pyranopyrazoles. The results with [OPPh3][Br] are not as good as those obtained with [MePPh3][Br], which certainly due to its cumbersome properties.
- This study reinforced the idea of the organic catalysis in MCRs giving the
pyrazolopyranopyrimidindiones/ones the pyranopyrazoles and the spirooxindoles
heterocyclic compoundsDiplôme : Doctorat En ligne : ../theses/chimie/BOU6898.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10228 Élaboration de nouvelles voies catalytiques dans la synthese de molécules hétérocycliques [texte imprimé] / Faiza Boukezzoula, Auteur ; Taoues Boumoud, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2016 . - 196 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : hétérocycles synthèse convergente réactions à composants multiples catalyse
organique molécules chirales et achirales synthèse asymétrique liquides ioniques pyrazolopyranopyrimidines pyranopyrazoles spirooxindoles heterocyclic compounds convergent strategy MCRs Organocatalysis asymmetrical and symmetrical molecules asymmetric synthesis ionic liquids المركبات الحلقية الغير متجانسة التفاعلات الكيماوية المتعددة المتفاعلات المحفزات العضوية المركبات الكيرالية ولاكيرالية السوائل الأيونية بيرازولوبيرانوابيرميدين بيرنوابيرازول سبيروا اكسندولIndex. décimale : 540 Chimie et sciences connexes Résumé : The subject that we developed "Elaboration of novel catalytic methods for the synthesis of
heterocyclic molecules " summarizes:
- Through a bibliographical study which puts forward the heterocyclic compounds, the advantage of the reactions making their synthesis possible, in occurrence MCRs and the privilege of organic catalysis.
- Through a study of the catalytic properties of two molecules asymmetrical (DMAP and DABCO) and two symmetrical (L-Proline and Cinchonine) with respect to the synthesis of
pyrazolpyrnopyrimidindiones/ones and pyranopyrazoles, via multicomponent reactions
- Through a study of catalytic properties of two ionic liquids [MePPh3][Br] and [OPPh3][Br] in the synthesis of the spirooxindoles and the pyranopyrazoles. The results with [OPPh3][Br] are not as good as those obtained with [MePPh3][Br], which certainly due to its cumbersome properties.
- This study reinforced the idea of the organic catalysis in MCRs giving the
pyrazolopyranopyrimidindiones/ones the pyranopyrazoles and the spirooxindoles
heterocyclic compoundsDiplôme : Doctorat En ligne : ../theses/chimie/BOU6898.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10228 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité BOU/6898 BOU/6898 Thèse Bibliothèque principale Thèses Disponible
Titre : Nouvelles voies de synthèse des hétérocycles et des dipeptides à tête prosthétique Type de document : texte imprimé Auteurs : Imane Tebabel, Auteur ; Taoues Boumoud, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2017 Importance : 206 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Dihydropyrimidinones DHPMs liquide ionique thiazolopyrimidinones oxadiazolopyrimidines dipepetide Biginelli et pseudo Hantzsch nitrate d'ammonium ionic liquid Biginelli and Hantzsch-like مشتقات الدي هيدروبيريميدينون DHPM السائل الأيوني من ثیازولو[2,3-a] بیریمیدین3- (H25-
بنزیلدینثیازولو[2,3-a]بیریمیدین الأ كسادزول 3-سيانوبيريدون ثنائي الببتیدIndex. décimale : 540 Chimie et sciences connexes Résumé : In the first chapter, we developed a novel catalytic synthesis of 3,4-
dihydropyrimidinones via Biginelli reaction in the presence of a bronsted ionic liquid [H-val]
HSO4 as the reaction medium. Then, we performed the synthesis of thiazolo[3,2-
a]pyrimidin-3(5H)-ones via Hantzsch thiazoles synthesis using bromide ethylacetoacetate as
an alkylatig agent in refluxed acetone, this novel method allowed to prepare these fused
heterocyclic compounds in good yields. Lability of hydrogens in previous derivatives allowed
to prepare new 2-benzilidénethiazolo[3,2-a]pyrimidin-3(5H)-ones via two methods: divergent
and convergent from DHPMs as starting materials.
In addition in the second chapter, we were interested in the development of novel
synthesis of 2-cyanopyridones via Hantzsch-like reaction using ammonium nitrate instead of the usually used ammonium acetate. Then we carried out several consecutive reactions on
these heterocyclic compounds to achieve the desired products: oxadiazolopyridines.
In the third chapter, we have prepared some dipeptide N-cyanopyridines from
cyanopyridines by carrying out some consecutive reactions.
Diplôme : Doctorat en sciences En ligne : ../theses/chimie/TEB7138.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10464 Nouvelles voies de synthèse des hétérocycles et des dipeptides à tête prosthétique [texte imprimé] / Imane Tebabel, Auteur ; Taoues Boumoud, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2017 . - 206 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Dihydropyrimidinones DHPMs liquide ionique thiazolopyrimidinones oxadiazolopyrimidines dipepetide Biginelli et pseudo Hantzsch nitrate d'ammonium ionic liquid Biginelli and Hantzsch-like مشتقات الدي هيدروبيريميدينون DHPM السائل الأيوني من ثیازولو[2,3-a] بیریمیدین3- (H25-
بنزیلدینثیازولو[2,3-a]بیریمیدین الأ كسادزول 3-سيانوبيريدون ثنائي الببتیدIndex. décimale : 540 Chimie et sciences connexes Résumé : In the first chapter, we developed a novel catalytic synthesis of 3,4-
dihydropyrimidinones via Biginelli reaction in the presence of a bronsted ionic liquid [H-val]
HSO4 as the reaction medium. Then, we performed the synthesis of thiazolo[3,2-
a]pyrimidin-3(5H)-ones via Hantzsch thiazoles synthesis using bromide ethylacetoacetate as
an alkylatig agent in refluxed acetone, this novel method allowed to prepare these fused
heterocyclic compounds in good yields. Lability of hydrogens in previous derivatives allowed
to prepare new 2-benzilidénethiazolo[3,2-a]pyrimidin-3(5H)-ones via two methods: divergent
and convergent from DHPMs as starting materials.
In addition in the second chapter, we were interested in the development of novel
synthesis of 2-cyanopyridones via Hantzsch-like reaction using ammonium nitrate instead of the usually used ammonium acetate. Then we carried out several consecutive reactions on
these heterocyclic compounds to achieve the desired products: oxadiazolopyridines.
In the third chapter, we have prepared some dipeptide N-cyanopyridines from
cyanopyridines by carrying out some consecutive reactions.
Diplôme : Doctorat en sciences En ligne : ../theses/chimie/TEB7138.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10464 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité TEB/7138 TEB/7138 Thèse Bibliothèque principale Thèses Disponible
Titre : Synthèse de composés hétérocycliques à visée anticancèreuse Type de document : texte imprimé Auteurs : Nora Chouha, Auteur ; Taoues Boumoud, Auteur ; Laurent Desaubry, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2018 Importance : 155 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Triarylimidazoles spirooxindoles acide citrique BF3.OEt2 iminobenzimidazole fluorizoline oncogène KRAS cytotoxicité leucémie citric acid KRAS oncogene cytotoxicity leukemia Index. décimale : 540 Chimie et sciences connexes Résumé : Our work focuses on the development of new synthetic approaches to anticancer compounds. This work was carried out at the University of Constantine and Strasbourg, under Prof. Taoues Boumoud and Dr. Laurent Désaubry’s supervision. Triarylimidazoles and spirooxindoles are heterocycles found among several important anti-cancer agents. In order to facilitate the pharmacochemical exploration of these compounds, improving their synthesis was aimed. Novel catalytic ways were developped for the synthesis of triarylimidazoles and spiro[chroméne-oxindoles] with good yields via multicomponent reactions in the presence of citric acid and BF3.OEt2 as catalysts respectively. Two articles demonstarting the catalytic effects of the former catalysts in the synthesis of benzimidazoles and spirooxindole derivatives were published. Original work carried out in Strasbourg has demonstrated the cytotoxic properties of an iminobenzimidazole on cancerous lines. Analogues of this compound, were prepered, to determine the structural requirements for this cytotoxicity. An article describing these works was published inThe Open Medicinal Chemistry Journal. Another cytotoxic agent “fluorizoline” and analogues thereof were also prepared. Two first articles demonstrating the inhibition of KRAS oncogene by this compound and its activity in models of chronic lymphocytic leukemia were also published.
Diplôme : Doctorat En ligne : ../theses/chimie/CHO7370.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11019 Synthèse de composés hétérocycliques à visée anticancèreuse [texte imprimé] / Nora Chouha, Auteur ; Taoues Boumoud, Auteur ; Laurent Desaubry, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2018 . - 155 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Triarylimidazoles spirooxindoles acide citrique BF3.OEt2 iminobenzimidazole fluorizoline oncogène KRAS cytotoxicité leucémie citric acid KRAS oncogene cytotoxicity leukemia Index. décimale : 540 Chimie et sciences connexes Résumé : Our work focuses on the development of new synthetic approaches to anticancer compounds. This work was carried out at the University of Constantine and Strasbourg, under Prof. Taoues Boumoud and Dr. Laurent Désaubry’s supervision. Triarylimidazoles and spirooxindoles are heterocycles found among several important anti-cancer agents. In order to facilitate the pharmacochemical exploration of these compounds, improving their synthesis was aimed. Novel catalytic ways were developped for the synthesis of triarylimidazoles and spiro[chroméne-oxindoles] with good yields via multicomponent reactions in the presence of citric acid and BF3.OEt2 as catalysts respectively. Two articles demonstarting the catalytic effects of the former catalysts in the synthesis of benzimidazoles and spirooxindole derivatives were published. Original work carried out in Strasbourg has demonstrated the cytotoxic properties of an iminobenzimidazole on cancerous lines. Analogues of this compound, were prepered, to determine the structural requirements for this cytotoxicity. An article describing these works was published inThe Open Medicinal Chemistry Journal. Another cytotoxic agent “fluorizoline” and analogues thereof were also prepared. Two first articles demonstrating the inhibition of KRAS oncogene by this compound and its activity in models of chronic lymphocytic leukemia were also published.
Diplôme : Doctorat En ligne : ../theses/chimie/CHO7370.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11019 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité CHO/7370 CHO/7370 Thèse Bibliothèque principale Thèses Disponible
