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Partager le résultat de cette recherche Interroger des sources externesChronobiologie et propriétés sensorio-motrices de la sensitive (mimosa pudica L.) (proposition donnée par la faculté) la théorie endosymbiotique des mitochondries / Gabriel Roblin
Titre : Chronobiologie et propriétés sensorio-motrices de la sensitive (mimosa pudica L.) (proposition donnée par la faculté) la théorie endosymbiotique des mitochondries Type de document : texte imprimé Auteurs : Gabriel Roblin, Auteur ; Univ. de Poitiers, Editeur scientifique ; P. Gavaudan, Directeur de thèse Année de publication : 1975 Importance : 306 f. Note générale : 01 Disponible au magasin de la bibliothèque centrale Langues : Français (fre) Tags : Mitochondrie Chromobiologie Sensitivité Endosymbiotique Index. décimale : 570 Sciences de la vie. Biologie Diplôme : Doctorat en sciences Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=1506 Chronobiologie et propriétés sensorio-motrices de la sensitive (mimosa pudica L.) (proposition donnée par la faculté) la théorie endosymbiotique des mitochondries [texte imprimé] / Gabriel Roblin, Auteur ; Univ. de Poitiers, Editeur scientifique ; P. Gavaudan, Directeur de thèse . - 1975 . - 306 f.
01 Disponible au magasin de la bibliothèque centrale
Langues : Français (fre)
Tags : Mitochondrie Chromobiologie Sensitivité Endosymbiotique Index. décimale : 570 Sciences de la vie. Biologie Diplôme : Doctorat en sciences Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=1506 Exemplaires
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Titre : Activité structure des mitochondries isolées durant la germination chez le blé tendre : relation avec l'hétérosis et la stérilité mÐle cytoplasmique Type de document : texte imprimé Auteurs : Univ. de Paris-Sud, Editeur scientifique Année de publication : 1977 Importance : 88 f. Note générale : 01 Disponible dans la salle de recherche Langues : Français (fre) Tags : Blé tendre Germination Heterosis Mitochondrie Stérilité MÐle cytoplasmique Index. décimale : 570 Sciences de la vie. Biologie Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=1595 Activité structure des mitochondries isolées durant la germination chez le blé tendre : relation avec l'hétérosis et la stérilité mÐle cytoplasmique [texte imprimé] / Univ. de Paris-Sud, Editeur scientifique . - 1977 . - 88 f.
01 Disponible dans la salle de recherche
Langues : Français (fre)
Tags : Blé tendre Germination Heterosis Mitochondrie Stérilité MÐle cytoplasmique Index. décimale : 570 Sciences de la vie. Biologie Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=1595 Exemplaires
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Titre : Génétique mitochondriale des infertilités masculines Type de document : texte imprimé Auteurs : Mohamed Larbi Rezgoune, Auteur ; Dalila Satta, Directeur de thèse ; Abdelhamid Slama, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2016 Importance : 187 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Tags : mitochondrie polymorphisme infertilité masculine biologie moléculaire mitochondria polymorphism male infertility molecular biology ???????????? ???? ??????? ?????? ???????? ??????? ??? ?????? ?????????? ???????? Index. décimale : 570 Sciences de la vie. Biologie Résumé : Mitochondria play a central role in energy metabolism, homeostasis and apoptosis.
These functions are in part under the control of a mitochondrial genome, support of cytoplasmic heredity, whose transmission is only maternal. The involvement of these organelles in human reproduction is a relatively new concept that arouses scientific and medical interest. Abnormalities both qualitative and quantitative of mitochondrial DNA (mtDNA) have been associated with male fertility disorders.
Infertility concerns 10 to 15 % of couples wishing to have a child, a male component is found
in almost half of cases. In a significant proportion of these cases, a known genetic basis,
chromosomal or gene, sometimes transmitted from the parents, is involved.
In this work, in a first part, different genetic polymorphisms in humans: (CAG)n POLG1,T3801C CYP1A1 and MTHFR A1298C, and their role as potential risk factors for male infertility in an Algerian population cohort were studied by sequencing or RFLP.
Our results show that the variants described at the MTHFR and CYP1A1 genes are not associated with male infertility unlike that of POLG1 which appears to be involved in this dysfunction.
In the second part of our work, we have prospected qualitative alterations of mitochondrial
genome by analysis of macro-deletions by long PCR and quantitative by quantification of leukocyte mtDNA rate by real-time quantitative PCR (mitochondrial DNA vs nuclear) in idiopathic male infertility. The mtDNA deletion does not appear to be associated with this disorder but the assessment of the level of leukocyte mtDNA likely suggests the involvement of this parameter in male infertility especially in azoospermic and asthenospermic men.
Molecular biology has led to the discovery of unexplored etiologies until now without denigrating the clinical and biological explanatory value of many recognized etiologies.
This mitochondrial molecular appearance misunderstood opens up new perspectives and may in the future introduce profound changes in the genetic approach to male infertility.
Diplôme : Doctorat en sciences En ligne : ../theses/biologie/REZ7000.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10389 Génétique mitochondriale des infertilités masculines [texte imprimé] / Mohamed Larbi Rezgoune, Auteur ; Dalila Satta, Directeur de thèse ; Abdelhamid Slama, Directeur de thèse . - [S.l.] : جامعة الإخوة منتوري قسنطينة, 2016 . - 187 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Tags : mitochondrie polymorphisme infertilité masculine biologie moléculaire mitochondria polymorphism male infertility molecular biology ???????????? ???? ??????? ?????? ???????? ??????? ??? ?????? ?????????? ???????? Index. décimale : 570 Sciences de la vie. Biologie Résumé : Mitochondria play a central role in energy metabolism, homeostasis and apoptosis.
These functions are in part under the control of a mitochondrial genome, support of cytoplasmic heredity, whose transmission is only maternal. The involvement of these organelles in human reproduction is a relatively new concept that arouses scientific and medical interest. Abnormalities both qualitative and quantitative of mitochondrial DNA (mtDNA) have been associated with male fertility disorders.
Infertility concerns 10 to 15 % of couples wishing to have a child, a male component is found
in almost half of cases. In a significant proportion of these cases, a known genetic basis,
chromosomal or gene, sometimes transmitted from the parents, is involved.
In this work, in a first part, different genetic polymorphisms in humans: (CAG)n POLG1,T3801C CYP1A1 and MTHFR A1298C, and their role as potential risk factors for male infertility in an Algerian population cohort were studied by sequencing or RFLP.
Our results show that the variants described at the MTHFR and CYP1A1 genes are not associated with male infertility unlike that of POLG1 which appears to be involved in this dysfunction.
In the second part of our work, we have prospected qualitative alterations of mitochondrial
genome by analysis of macro-deletions by long PCR and quantitative by quantification of leukocyte mtDNA rate by real-time quantitative PCR (mitochondrial DNA vs nuclear) in idiopathic male infertility. The mtDNA deletion does not appear to be associated with this disorder but the assessment of the level of leukocyte mtDNA likely suggests the involvement of this parameter in male infertility especially in azoospermic and asthenospermic men.
Molecular biology has led to the discovery of unexplored etiologies until now without denigrating the clinical and biological explanatory value of many recognized etiologies.
This mitochondrial molecular appearance misunderstood opens up new perspectives and may in the future introduce profound changes in the genetic approach to male infertility.
Diplôme : Doctorat en sciences En ligne : ../theses/biologie/REZ7000.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10389 Exemplaires
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Titre : Les interactions fonctionnelles des flavonoïdes de l’extrait butanolique de la plante Heliotropium undulatum vis-à-vis des mécanismes de l’hépatoxicité de l’hydrazine chez le rat. Type de document : texte imprimé Auteurs : Ouafa Deffa, Auteur ; Souad Ameddah, Directeur de thèse ; Ratiba Mekkiou, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2018 Importance : 127 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Tags : Heliotropium undulatum Hydrazine Foie Stress oxydant Inflammation Cyp2E1 Mitochondrie HPLC/MS liver Oxidative stress Mitochondria ?????????? ????? ??????? ???????? ???????????? Index. décimale : 570 Sciences de la vie. Biologie Résumé : The work presented in this thesis contributes to the valorization of the aerial part of an endemic plant collected from the Algerian Sahara, Heliotropium undulatum Vahl (the family Boraginaceae). This study was conducted to evaluate the antioxidant and antiinflammatory activities of n-BuOH extracts of stems and leaves of H. undulatum using a rat- hydrazine model. In vitro studies (DPPH°, Chelation, FRAP, °OH) reveal that the n-BuOH extract of leaves has an antioxidant property. In vivo studies have also shown that the n-BuOH extract of 200 mg/kg leaves has demonstrated hepatoprotective activity by preserving liver function, modulating CYP2E1, neutralizing hepatic oxidative stress, and providing intra- mitochondrial redox status exhibited during treatment with hydrazine (300 mg/kg). The antiinflammatory activity was better pronounced by the n-BuOH extract of the stems, the demonstration of which is carried out using various in vitro tests (denaturation of albumin, HRBC, NO° scavenger). The study of modulatory pathways (hepatic carbonyl proteins, MPO, levels of NO, IL-ip and TNF-a) confirmed the in vivo anti-inflammatory potential of the n- BuOH extract of stems. The set of concomitant antioxidant and anti-inflammatory mechanisms characterizing the two extracts of Heliotropiuin undulatum is correlated with the qualitative and quantitative nature of the phenolic acids and flavonoids revealed via HPLC- MASS analysis and with the synergetic effect of all the phytoconstituents contained in this plant
Diplôme : Doctorat en sciences En ligne : ../theses/biologie/DEF7374.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=11023 Les interactions fonctionnelles des flavonoïdes de l’extrait butanolique de la plante Heliotropium undulatum vis-à-vis des mécanismes de l’hépatoxicité de l’hydrazine chez le rat. [texte imprimé] / Ouafa Deffa, Auteur ; Souad Ameddah, Directeur de thèse ; Ratiba Mekkiou, Directeur de thèse . - [S.l.] : جامعة الإخوة منتوري قسنطينة, 2018 . - 127 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Tags : Heliotropium undulatum Hydrazine Foie Stress oxydant Inflammation Cyp2E1 Mitochondrie HPLC/MS liver Oxidative stress Mitochondria ?????????? ????? ??????? ???????? ???????????? Index. décimale : 570 Sciences de la vie. Biologie Résumé : The work presented in this thesis contributes to the valorization of the aerial part of an endemic plant collected from the Algerian Sahara, Heliotropium undulatum Vahl (the family Boraginaceae). This study was conducted to evaluate the antioxidant and antiinflammatory activities of n-BuOH extracts of stems and leaves of H. undulatum using a rat- hydrazine model. In vitro studies (DPPH°, Chelation, FRAP, °OH) reveal that the n-BuOH extract of leaves has an antioxidant property. In vivo studies have also shown that the n-BuOH extract of 200 mg/kg leaves has demonstrated hepatoprotective activity by preserving liver function, modulating CYP2E1, neutralizing hepatic oxidative stress, and providing intra- mitochondrial redox status exhibited during treatment with hydrazine (300 mg/kg). The antiinflammatory activity was better pronounced by the n-BuOH extract of the stems, the demonstration of which is carried out using various in vitro tests (denaturation of albumin, HRBC, NO° scavenger). The study of modulatory pathways (hepatic carbonyl proteins, MPO, levels of NO, IL-ip and TNF-a) confirmed the in vivo anti-inflammatory potential of the n- BuOH extract of stems. The set of concomitant antioxidant and anti-inflammatory mechanisms characterizing the two extracts of Heliotropiuin undulatum is correlated with the qualitative and quantitative nature of the phenolic acids and flavonoids revealed via HPLC- MASS analysis and with the synergetic effect of all the phytoconstituents contained in this plant
Diplôme : Doctorat en sciences En ligne : ../theses/biologie/DEF7374.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=11023 Exemplaires
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