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Auteur Zahia Kabouche |
Documents disponibles écrits par cet auteur (18)
Affiner la recherche Interroger des sources externesComposants et potentiel biologique de Cotula anthemoides L et Pentzia monodiana MAIRE. (Asteraceae). / Wafa Tadrent ép Laouadi
Titre : Composants et potentiel biologique de Cotula anthemoides L et Pentzia monodiana MAIRE. (Asteraceae). Type de document : texte imprimé Auteurs : Wafa Tadrent ép Laouadi, Auteur ; Zahia Kabouche, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2018 Importance : 233 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Cotula anthemoides L Pentzia monodiana Maire Asteraceae lignanes flavonoïdes sesquiterpènes lactones activité antioxydante activité anticholinesterase activité
antityrosinase sesquiterpenes lactones antioxidant activity anticholinesterase activity antityrosinase activity فلافونيدات lignanesضد الأكسدة ضد الكولينستراز و ضد التيروزينازIndex. décimale : 540 Chimie et sciences connexes Résumé : The present work concerns the phytochemical and biological studies of areal parts of two Algerian plants belonging to the Asteraceae family: Cotula anthemoides L. and Pentzia monodiana Maire. This study led to the isolation and identification of fifteen compounds of Cotula anthemoides and eight compounds of Pentzia monodiana including five phenolic acids, nine flavonoids from which one is new, three lignans, one sesquiterpene lactone, two glycosyl phenolics, a glycosyl acid, a diterpene and an nucleoside. The structural determination of the isolated compounds was established by the use of 1D and 2D NMR spectroscopic techniques (1H, 13C, COSY, HSQC, HMBC and ROESY), by mass spectrometry (ESI-MS and HRESI-MS) and by comparison with the literature data. The evaluation of the antioxidant activity by 4 methods (DPPH, ABTS, CUPRAC and chelating by ferrous ions) of the various extracts, showed a good activity of extracts from P. monodiana compared to those of C. anthemoides. Furthermore, extracts of C. anthemoides showed an interesting anticholinesterase activity. However, both of lignanes, flavonol and flavones substituted in C-3, exhibited better antityrosinase and antiradical activities than some flavones only.
Diplôme : Doctorat En ligne : ../theses/chimie/TAD7353.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=11002 Composants et potentiel biologique de Cotula anthemoides L et Pentzia monodiana MAIRE. (Asteraceae). [texte imprimé] / Wafa Tadrent ép Laouadi, Auteur ; Zahia Kabouche, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2018 . - 233 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Cotula anthemoides L Pentzia monodiana Maire Asteraceae lignanes flavonoïdes sesquiterpènes lactones activité antioxydante activité anticholinesterase activité
antityrosinase sesquiterpenes lactones antioxidant activity anticholinesterase activity antityrosinase activity فلافونيدات lignanesضد الأكسدة ضد الكولينستراز و ضد التيروزينازIndex. décimale : 540 Chimie et sciences connexes Résumé : The present work concerns the phytochemical and biological studies of areal parts of two Algerian plants belonging to the Asteraceae family: Cotula anthemoides L. and Pentzia monodiana Maire. This study led to the isolation and identification of fifteen compounds of Cotula anthemoides and eight compounds of Pentzia monodiana including five phenolic acids, nine flavonoids from which one is new, three lignans, one sesquiterpene lactone, two glycosyl phenolics, a glycosyl acid, a diterpene and an nucleoside. The structural determination of the isolated compounds was established by the use of 1D and 2D NMR spectroscopic techniques (1H, 13C, COSY, HSQC, HMBC and ROESY), by mass spectrometry (ESI-MS and HRESI-MS) and by comparison with the literature data. The evaluation of the antioxidant activity by 4 methods (DPPH, ABTS, CUPRAC and chelating by ferrous ions) of the various extracts, showed a good activity of extracts from P. monodiana compared to those of C. anthemoides. Furthermore, extracts of C. anthemoides showed an interesting anticholinesterase activity. However, both of lignanes, flavonol and flavones substituted in C-3, exhibited better antityrosinase and antiradical activities than some flavones only.
Diplôme : Doctorat En ligne : ../theses/chimie/TAD7353.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=11002 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité TAD/7353 TAD/7353 Thèse Bibliothèque principale Thèses Disponible
Titre : Composition chimique et évaluation des activites biologiques des huiles essentielles de Pistacia atlantica Desf.et de Ferula vesceritensis Coss. & Dur. et synthese catalytique de nouveaux dérivés pipéridiniques Type de document : texte imprimé Auteurs : Ilhem Labed ep Zouad, Auteur ; Zahia Kabouche, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2015 Importance : 211 f. Format : 30 cm. Note générale : 2 copies imprimes disponibles Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Chimie pharmaceutique Ferula vesceritensis Coss. & Dur. antioxydante anticholinestérase antibactérienne couplage oxydant énamides pipéridines hydroboration hydrogénation Pistacia atlantica Desf. antioxidant anticholinesterase antibacterial oxidative coupling enamides hydrogenation hydrobration piperidines Index. décimale : 540 Chimie et sciences connexes Résumé : In a first part we studied the chemical composition and biological activities of Pistacia
atlantica Desf. and Ferula vesceritensis Coss. & Dur. The GC and GC-MS analyses
showed that the essential oils of P. atlantica are rich in α-pinene, limonene and spatulenol,
while β-phellandrene, α-terpinene, β-elemene, γ-gurjunene and germacrene-B were found
as major components, for the first time for the essential oils of the genus Pistacia .
α-Pinene and β- pinene were predominant in the essential oils of Ferula vesceritensis;
however the first time that α-phellandrene, fenchylacetate, elixene, l'aristolene and cartol
were found as main components in the essential oils of the genus Ferula . The both essential
oils of P. atlantica . and F. vesceritensis exhibited a good antibacterial activity against
clinical isolated bacteria and food borne pathogens. The essential oils of P. atlantica
possess an important antioxidant effect which were determined using β-carotene-linoleic
acid, DPPH- and ABTS•+ -scavenging activities, metal chelating effect and CUPRAC
assays. The essential oils showed a moderate anticholinestérase activity compared with
galantamin for the inhibitory activity of principal enzymes of Alzheimer’s disease AChE
and BChE.
In a second part, we synthesized 12 new piperidine derivatives, which have been achieved
through [Cp*Ru]-catalyzed intermolecular coupling of allylic alcohols and propargylic
amides with water as the only side product, and demonstrated that the selective
oxidativecoupling cinnamyl alcohol derivatives and 2-substituted allylic alcohols. This
methodology allows the access to 3,4- and 3,5-disubstituted enamides as valuable
scaffolds for the preparation of 3-methylpiperidine derivatives through selective [Cp*Ru]
catalyzed alkene hydrogenation.Diplôme : Doctorat En ligne : ../theses/chimie/LAB6834.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10126 Composition chimique et évaluation des activites biologiques des huiles essentielles de Pistacia atlantica Desf.et de Ferula vesceritensis Coss. & Dur. et synthese catalytique de nouveaux dérivés pipéridiniques [texte imprimé] / Ilhem Labed ep Zouad, Auteur ; Zahia Kabouche, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2015 . - 211 f. ; 30 cm.
2 copies imprimes disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Chimie pharmaceutique Ferula vesceritensis Coss. & Dur. antioxydante anticholinestérase antibactérienne couplage oxydant énamides pipéridines hydroboration hydrogénation Pistacia atlantica Desf. antioxidant anticholinesterase antibacterial oxidative coupling enamides hydrogenation hydrobration piperidines Index. décimale : 540 Chimie et sciences connexes Résumé : In a first part we studied the chemical composition and biological activities of Pistacia
atlantica Desf. and Ferula vesceritensis Coss. & Dur. The GC and GC-MS analyses
showed that the essential oils of P. atlantica are rich in α-pinene, limonene and spatulenol,
while β-phellandrene, α-terpinene, β-elemene, γ-gurjunene and germacrene-B were found
as major components, for the first time for the essential oils of the genus Pistacia .
α-Pinene and β- pinene were predominant in the essential oils of Ferula vesceritensis;
however the first time that α-phellandrene, fenchylacetate, elixene, l'aristolene and cartol
were found as main components in the essential oils of the genus Ferula . The both essential
oils of P. atlantica . and F. vesceritensis exhibited a good antibacterial activity against
clinical isolated bacteria and food borne pathogens. The essential oils of P. atlantica
possess an important antioxidant effect which were determined using β-carotene-linoleic
acid, DPPH- and ABTS•+ -scavenging activities, metal chelating effect and CUPRAC
assays. The essential oils showed a moderate anticholinestérase activity compared with
galantamin for the inhibitory activity of principal enzymes of Alzheimer’s disease AChE
and BChE.
In a second part, we synthesized 12 new piperidine derivatives, which have been achieved
through [Cp*Ru]-catalyzed intermolecular coupling of allylic alcohols and propargylic
amides with water as the only side product, and demonstrated that the selective
oxidativecoupling cinnamyl alcohol derivatives and 2-substituted allylic alcohols. This
methodology allows the access to 3,4- and 3,5-disubstituted enamides as valuable
scaffolds for the preparation of 3-methylpiperidine derivatives through selective [Cp*Ru]
catalyzed alkene hydrogenation.Diplôme : Doctorat En ligne : ../theses/chimie/LAB6834.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10126 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité LAB/6834 LAB/6834 Thèse Bibliothèque principale Thèses Disponible
Titre : "Drug Design" et synthèse de nouveaux calix[8]arènes sulfoniques flexibles à activités anticorrosive et anticoagulante Type de document : texte imprimé Auteurs : Seifeddine Rekkab, Auteur ; Zahia Kabouche, Directeur de thèse Editeur : constantine [Algérie] : Université Constantine 1 Année de publication : 2014 Importance : 157 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : Calixarènes sulfonique, activité anticorrosive, activité anticoagulante, POM.
sulfonic Calixarenes, anticorrosive activity, anticoagulant activity, POM.
.POM ,Calixarènes sulfoniques ضد التآكل،ضد تخثر الدمIndex. décimale : 540 Chimie et sciences connexes Résumé : "In this work, We developed a new method of the synthesis of sulfonic
calix[8]arenes derivatives.
We realized four substitution reactions of eight hydroxyl groups of
5,11,17,23,29,35,41,47-octa-tert-butyl-49,50,51,52,53,54,55,56-octakis calix[8]arene
and 49,50,51,52,53,54,55,56-octakis-calix[8]arene by 1,3-trimethylene and 1,4-
tetramethylene groups, leading respectively to the following four new sulfonic
calix[8]arenes :
• 5,11,17,23,29,35,41,47-octa-tert-butyl-49,50,51,52,53,54,55,56-octakis-
(3-propylsulphonic acid) calix[8]arene.
• 49,50,51,52,53,54,55,56-octakis-(3-propylsulphonic acid) calix[8]arene.
• 5,11,17,23,29,35,41,47-octa-tert-butyl-49,50,51,52,53,54,55,56-octakis-
(4-butylsulphonic acid) calix[8]arene.
• 49,50,51,52,53,54,55,56-octakis-(4-butylsulphonic acid) calix[8]arene).
The anticorrosive activity of the synthesized calix[8]arenes was studied by the
use of the three classical methods (gravimetric, potentiodynamic and impedance).
They showed an excellent inhibition of steel corrosion in HCl 1M.
The increase of the temperature decreases the inhibitory efficiency and the
calixarenes were adsorbed to the surface of steel according to isotherm model of
Langmuir, via a chemical adsorption.
The synthesized calixarenes showed an excellent in vivo and in vitro
anticoagulant activity, especially the derivative 5,11,17,23,29,35,41,47-octa-tertbutyl-
49,50,51,52,53,54,55,56-octakis-(4-butylsulphonic acid) calix[8]arene.
The POM (Petra, Osiris, Molinspiration) theory application on the synthesized
calixarenes showed that they are not toxic and that they are efficient as well as the
clinical coagulation inhibitors."
Diplôme : Doctorat en sciences En ligne : ../theses/chimie/REK6531.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=9646 "Drug Design" et synthèse de nouveaux calix[8]arènes sulfoniques flexibles à activités anticorrosive et anticoagulante [texte imprimé] / Seifeddine Rekkab, Auteur ; Zahia Kabouche, Directeur de thèse . - constantine [Algérie] : Université Constantine 1, 2014 . - 157 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : Calixarènes sulfonique, activité anticorrosive, activité anticoagulante, POM.
sulfonic Calixarenes, anticorrosive activity, anticoagulant activity, POM.
.POM ,Calixarènes sulfoniques ضد التآكل،ضد تخثر الدمIndex. décimale : 540 Chimie et sciences connexes Résumé : "In this work, We developed a new method of the synthesis of sulfonic
calix[8]arenes derivatives.
We realized four substitution reactions of eight hydroxyl groups of
5,11,17,23,29,35,41,47-octa-tert-butyl-49,50,51,52,53,54,55,56-octakis calix[8]arene
and 49,50,51,52,53,54,55,56-octakis-calix[8]arene by 1,3-trimethylene and 1,4-
tetramethylene groups, leading respectively to the following four new sulfonic
calix[8]arenes :
• 5,11,17,23,29,35,41,47-octa-tert-butyl-49,50,51,52,53,54,55,56-octakis-
(3-propylsulphonic acid) calix[8]arene.
• 49,50,51,52,53,54,55,56-octakis-(3-propylsulphonic acid) calix[8]arene.
• 5,11,17,23,29,35,41,47-octa-tert-butyl-49,50,51,52,53,54,55,56-octakis-
(4-butylsulphonic acid) calix[8]arene.
• 49,50,51,52,53,54,55,56-octakis-(4-butylsulphonic acid) calix[8]arene).
The anticorrosive activity of the synthesized calix[8]arenes was studied by the
use of the three classical methods (gravimetric, potentiodynamic and impedance).
They showed an excellent inhibition of steel corrosion in HCl 1M.
The increase of the temperature decreases the inhibitory efficiency and the
calixarenes were adsorbed to the surface of steel according to isotherm model of
Langmuir, via a chemical adsorption.
The synthesized calixarenes showed an excellent in vivo and in vitro
anticoagulant activity, especially the derivative 5,11,17,23,29,35,41,47-octa-tertbutyl-
49,50,51,52,53,54,55,56-octakis-(4-butylsulphonic acid) calix[8]arene.
The POM (Petra, Osiris, Molinspiration) theory application on the synthesized
calixarenes showed that they are not toxic and that they are efficient as well as the
clinical coagulation inhibitors."
Diplôme : Doctorat en sciences En ligne : ../theses/chimie/REK6531.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=9646 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité REK/6531 REK/6531 Thèse Bibliothèque principale Thèses Disponible
Titre : "Étude phytochimique et activité antioxydante de Matricaria pubescens (Desf.) Sch. Bip. et Chrysanthemum deserticolum Batt. &Trab." : (ASTERACEAE) Type de document : texte imprimé Auteurs : Ouissem Gherboudj, Auteur ; Zahia Kabouche, Directeur de thèse Editeur : constantine [Algérie] : Université Constantine 1 Année de publication : 2014 Importance : 471 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : "Asteraceae, Matricaria pubescens, Chrysanthemum deserticolum, activité
antioxydante."
"Asteraceae, Matricaria pubescens, Chrysanthemum deserticolum, antioxidant
activity."
فعالية مضادة للأكسدةIndex. décimale : 540 Chimie et sciences connexes Résumé : "Our phytochemical and biological works concerned the aerial parts of two endemic Saharian
species belonging to Asteraeae family: Matricaria pubescens (Desf.) Sch. Bip. and
Chrysanthemum deserticolum Batt. &Trab., collected from Ghardaïa.
Several chromatographic methods were used in our experimental works which allowed us to
isolate eleven products from the butanolic extract of Matricaria pubescens from wich three
are new, and twenty six products from Chrysanthemum deserticolum from wich seventeen
were identified and among wich one was isolated for the first time from a natural source.
Structures were determined by different spectral methods: nuclear magnetic resonance with
different applications (NMR 1H, NMR -13C, DEPT, COSY, HMQC, HMBC and NOESY),
the mass spectrometry, UV, as well as comparison with literature data.
Butanolic and ethyl acetate phases of the two studied species together with two flavonoids
(luteolin- 7-O-β-D-glucoside and 4 `-O-methylisoscutellarein-7-O-[6''-O-acetyl-β-D-glucosyl-
(1→ 2)-β-D-glucoside]), isolated from Matricaria pubescens, showed an excellent
antioxidant activity, by the use of DPPH and ABTS methods."
Diplôme : Doctorat En ligne : ../theses/chimie/GHE6499.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=9615 "Étude phytochimique et activité antioxydante de Matricaria pubescens (Desf.) Sch. Bip. et Chrysanthemum deserticolum Batt. &Trab." : (ASTERACEAE) [texte imprimé] / Ouissem Gherboudj, Auteur ; Zahia Kabouche, Directeur de thèse . - constantine [Algérie] : Université Constantine 1, 2014 . - 471 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : "Asteraceae, Matricaria pubescens, Chrysanthemum deserticolum, activité
antioxydante."
"Asteraceae, Matricaria pubescens, Chrysanthemum deserticolum, antioxidant
activity."
فعالية مضادة للأكسدةIndex. décimale : 540 Chimie et sciences connexes Résumé : "Our phytochemical and biological works concerned the aerial parts of two endemic Saharian
species belonging to Asteraeae family: Matricaria pubescens (Desf.) Sch. Bip. and
Chrysanthemum deserticolum Batt. &Trab., collected from Ghardaïa.
Several chromatographic methods were used in our experimental works which allowed us to
isolate eleven products from the butanolic extract of Matricaria pubescens from wich three
are new, and twenty six products from Chrysanthemum deserticolum from wich seventeen
were identified and among wich one was isolated for the first time from a natural source.
Structures were determined by different spectral methods: nuclear magnetic resonance with
different applications (NMR 1H, NMR -13C, DEPT, COSY, HMQC, HMBC and NOESY),
the mass spectrometry, UV, as well as comparison with literature data.
Butanolic and ethyl acetate phases of the two studied species together with two flavonoids
(luteolin- 7-O-β-D-glucoside and 4 `-O-methylisoscutellarein-7-O-[6''-O-acetyl-β-D-glucosyl-
(1→ 2)-β-D-glucoside]), isolated from Matricaria pubescens, showed an excellent
antioxidant activity, by the use of DPPH and ABTS methods."
Diplôme : Doctorat En ligne : ../theses/chimie/GHE6499.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=9615 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité GHE/6499 GHE/6499 Thèse Bibliothèque principale Thèses Disponible
Titre : "Etude phytochimique et activités antioxydante, antiproliférative, antibactérienne et antivirale d’extraits et d’huiles essentielles de quatre espèces endémiques du genre Thymus." Type de document : texte imprimé Auteurs : Assia Zeghib, Auteur ; Zahia Kabouche, Directeur de thèse ; Claude-Alain Calliste, Directeur de thèse Editeur : constantine [Algérie] : Université Constantine 1 Année de publication : 2013 Importance : 154 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
ChimieTags : "Thymus guyonii De Noe, Thymus ciliatus Desf., Thymus numidicus (Poiret), Thymus
hirtus Willd., extrait, huile essentielle, activités biologiques, investigation phytochimique."
"Thymus guyonii De Noe, Thymus ciliatus Desf., Thymus numidicus (Poiret),
Thymus hirtus Willd., extract, essential oil, biological activities, phytochemical investigation."
"Thymus ، Thymus guyonii De Noe, Thymus ciliatus Desf., Thymus numidicus (Poiret)
ان سًخخهص، الص جَ أساس ، ا ف لعان اُث ا ب ل ىُنىج تُ، انذساست انف خُىك اًُُئ تُ. ، hirtus Willd."Index. décimale : 540 Chimie et sciences connexes Résumé : "The antioxidant and antiproliferative activities investigation of the extracts of Thymus
guyonii De Noe, Thymus ciliatus Desf. and Thymus numidicus (Poiret) , shows that this latter
species presents the best biological potential : the most polar extracts are the most antioxidant
while the least polar extracts are the most antiproliferative.
The rosmarinic acid (10.61%) and the methyl rosmarinate (44.02%) were purified from the
T. numidicus methanol extract. The fractionnation of the T. numidicus hydro-ethanolic extract,
by increasing polarity solvents, allowed to concentrate the main compounds responsible of the
antioxidant activity in the ethyl acetate fraction. A flavone (luteolin, 4.54 %), a flavanol (quercetin,
0.64 %) and two phenolic acids (rosmarinic acid, 25.12 % and methyl rosmarinate, 15.53 %) were
isolated from the ethyl acetate fraction. All these isolated molecules are very active, with a CI50 in
approximately of 10 μg/mL.
The T. numidicus dichloromethane fraction presents the best bactericidal potential
towards the eight studied bacterial strains. The T. numidicus aqueous fraction is the only one to be
antiviral towards the coxsackievirus B3 strain.
The phytochemical investigation of the T. numidicus dichloromethane extract
(antiproliferative one), led to the obtaining of a cold precipitate similar to the ursolic acid and
containing 3 predominant products.
The GC and GC/MS analysis of T. guyonii essential oil showed that it is mainly composed
of : o-cymene (9,69 %), δ-terpinene (5,73 %), thymol (21,18 %) and carvacrol (55,60 %).
The GC and GC/MS analysis of Thymus hirtus Willd. essential oil showed that it is
mainly composed of : α-pinene (9,46 %), camphene (5,38 %), eucalyptol (1,8-cineole) (34,62 %)
and 2-bornanone (18,55 %).
The GC and GC/MS analysis of T. numidicus essential oil showed that it is mainly
composed of: thymol (23,92%), linalool (17,20%), o-cymene (11,41%), γ-terpinene (10,84%),
thymol methyl ether (6,73%) and carvacrol (6,02%).
The T. guyonii essential oil showed the better bactericidal activity towards the eight studied
bacterial strains, especially Staphylococcus aureus ATCC 25923 and Pseudomonas aeruginosa
ATCC 27853."
Diplôme : Doctorat en sciences En ligne : ../theses/chimie/ZEG6511.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=9625 "Etude phytochimique et activités antioxydante, antiproliférative, antibactérienne et antivirale d’extraits et d’huiles essentielles de quatre espèces endémiques du genre Thymus." [texte imprimé] / Assia Zeghib, Auteur ; Zahia Kabouche, Directeur de thèse ; Claude-Alain Calliste, Directeur de thèse . - constantine [Algérie] : Université Constantine 1, 2013 . - 154 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
ChimieTags : "Thymus guyonii De Noe, Thymus ciliatus Desf., Thymus numidicus (Poiret), Thymus
hirtus Willd., extrait, huile essentielle, activités biologiques, investigation phytochimique."
"Thymus guyonii De Noe, Thymus ciliatus Desf., Thymus numidicus (Poiret),
Thymus hirtus Willd., extract, essential oil, biological activities, phytochemical investigation."
"Thymus ، Thymus guyonii De Noe, Thymus ciliatus Desf., Thymus numidicus (Poiret)
ان سًخخهص، الص جَ أساس ، ا ف لعان اُث ا ب ل ىُنىج تُ، انذساست انف خُىك اًُُئ تُ. ، hirtus Willd."Index. décimale : 540 Chimie et sciences connexes Résumé : "The antioxidant and antiproliferative activities investigation of the extracts of Thymus
guyonii De Noe, Thymus ciliatus Desf. and Thymus numidicus (Poiret) , shows that this latter
species presents the best biological potential : the most polar extracts are the most antioxidant
while the least polar extracts are the most antiproliferative.
The rosmarinic acid (10.61%) and the methyl rosmarinate (44.02%) were purified from the
T. numidicus methanol extract. The fractionnation of the T. numidicus hydro-ethanolic extract,
by increasing polarity solvents, allowed to concentrate the main compounds responsible of the
antioxidant activity in the ethyl acetate fraction. A flavone (luteolin, 4.54 %), a flavanol (quercetin,
0.64 %) and two phenolic acids (rosmarinic acid, 25.12 % and methyl rosmarinate, 15.53 %) were
isolated from the ethyl acetate fraction. All these isolated molecules are very active, with a CI50 in
approximately of 10 μg/mL.
The T. numidicus dichloromethane fraction presents the best bactericidal potential
towards the eight studied bacterial strains. The T. numidicus aqueous fraction is the only one to be
antiviral towards the coxsackievirus B3 strain.
The phytochemical investigation of the T. numidicus dichloromethane extract
(antiproliferative one), led to the obtaining of a cold precipitate similar to the ursolic acid and
containing 3 predominant products.
The GC and GC/MS analysis of T. guyonii essential oil showed that it is mainly composed
of : o-cymene (9,69 %), δ-terpinene (5,73 %), thymol (21,18 %) and carvacrol (55,60 %).
The GC and GC/MS analysis of Thymus hirtus Willd. essential oil showed that it is
mainly composed of : α-pinene (9,46 %), camphene (5,38 %), eucalyptol (1,8-cineole) (34,62 %)
and 2-bornanone (18,55 %).
The GC and GC/MS analysis of T. numidicus essential oil showed that it is mainly
composed of: thymol (23,92%), linalool (17,20%), o-cymene (11,41%), γ-terpinene (10,84%),
thymol methyl ether (6,73%) and carvacrol (6,02%).
The T. guyonii essential oil showed the better bactericidal activity towards the eight studied
bacterial strains, especially Staphylococcus aureus ATCC 25923 and Pseudomonas aeruginosa
ATCC 27853."
Diplôme : Doctorat en sciences En ligne : ../theses/chimie/ZEG6511.pdf Format de la ressource électronique : Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=9625 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité ZEG/6511 ZEG/6511 Thèse Bibliothèque principale Thèses Disponible
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