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Auteur جميلة زعمة |
Documents disponibles écrits par cet auteur (5)
Affiner la recherche Interroger des sources externesRhantherium والمستخلص البوتانولي لنباتي C ،E دور فیتامین في الوقایة من التسمم Chrysanthemum fontanesii و suaveolens لدى الفئران الحوامل Sodium Valproate المحرض بدواء / أمال عمراني
Titre : Rhantherium والمستخلص البوتانولي لنباتي C ،E دور فیتامین في الوقایة من التسمم Chrysanthemum fontanesii و suaveolens لدى الفئران الحوامل Sodium Valproate المحرض بدواء : دراسةIn vitro و In vivo Type de document : texte imprimé Auteurs : أمال عمراني, Auteur ; جميلة زعمة, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2013 Importance : 140 ورقة. Format : 30 سم. Note générale : 2نسخ موجودة في المكتبة المركزية Langues : Arabe (ara) Catégories : Arabe
5 البيولوجياTags : Valproic acid embryotoxicity Oxidative stress, Lipid peroxidation, Plant extract, Flavonoids,
Vitamin E Vitamin C Chrysanthemum fontanesii Rhantherium suaveolens Antioxidant activity Phenolic
compounds DPPH Membrane stabilizing activity Antibacterial activity Anticancer activity.Index. décimale : 570 بيولوجيا Diplôme : Doctorat en sciences En ligne : ../theses/biologie/AAME3933.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=9390 Rhantherium والمستخلص البوتانولي لنباتي C ،E دور فیتامین في الوقایة من التسمم Chrysanthemum fontanesii و suaveolens لدى الفئران الحوامل Sodium Valproate المحرض بدواء : دراسةIn vitro و In vivo [texte imprimé] / أمال عمراني, Auteur ; جميلة زعمة, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2013 . - 140 ورقة. ; 30 سم.
2نسخ موجودة في المكتبة المركزية
Langues : Arabe (ara)
Catégories : Arabe
5 البيولوجياTags : Valproic acid embryotoxicity Oxidative stress, Lipid peroxidation, Plant extract, Flavonoids,
Vitamin E Vitamin C Chrysanthemum fontanesii Rhantherium suaveolens Antioxidant activity Phenolic
compounds DPPH Membrane stabilizing activity Antibacterial activity Anticancer activity.Index. décimale : 570 بيولوجيا Diplôme : Doctorat en sciences En ligne : ../theses/biologie/AAME3933.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=9390 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité عمر/3933 عمر/3933 Thèse Bibliothèque principale Thèses Disponible Documents numériques
AAME3933.pdfAdobe Acrobat PDF
Titre : دراسة الدور الوقائي لبعض المركبات النشطة بيولوجيا اتجاه الأثر السمي للمبيدات الهيدروكربونات على الجهاز العصبي و المناعي عند الجرذان Type de document : texte imprimé Auteurs : زهورة لقرون, Auteur ; جميلة زعمة, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2016 Importance : 122 ورقة. Format : 30 سم. Note générale : 2نسخ موجودة مكتبة المركزية
Langues : Arabe (ara) Catégories : Arabe
5 البيولوجياTags : لمبيدات الهيدروكاربونات الأندوسلفان النفتالين الجهاز العصبي الجهاز المناعي الأثر الوقائي والسمي، المستخلص الخام
لقشور البرتقال فيتامين C فيتامين E الكرستين الميتوكوندريات الإجهاد التأكسديIndex. décimale : 570 بيولوجيا Résumé : Environmental toxicology is nowadays facing a great challenge especially as it is addressing
to study the impact of toxic pollutants on the living organism of the general population, in
contrast to professional pharmacology or toxicology which target limited groups in their
professional and medical milieu with well-known diagnostic and therapeutic approaches.
Indeed, many food biological matrixes are contaminated with pesticides, polycyclic aromatic
hydrocarbons and heavy metals with very little concentrations that we consider such
negligible daily doses but which could accumulate with the time because their solubility in
different organs. This study focuses on the preventive effect of some bioactive compounds
such as vitamin C, vitamin E, quercetin and phenolic extract from orange peel Citrus
Senensis, against the toxic impact of a polycyclic aromatic hydrocarbon, the naphthalene and
endosulfan, as organochlorine pesticide on brain and immune systems. The results showed a
significant change in neuronal redox status in cytosol and brain mitochondria. Indeed,
endosulfan and naphthalene administered alone or in mixture at the respective doses of 2mg /
kg and 50 mg / kg, showed a disturbance in the balance prooxidant / antioxidant in cell
compartmentalization since they caused a significant fall in the level of GSH, GST, SOD and
CAT cytosolic rats treated with these chemicals. The results of these studies have also shown
a significant increase in MDA cytosolic and a highly significant reduction of cytosolic
proteins level was also recorded compared to the control group. Furthermore, the results of
this work have showed a very significant decrease in mitochondrial enzymatic activity of
SOD and CAT parallel to fall of GSH rate. Increased peroxidation was recorded via the
significant increase in mitochondrial MDA following animal exposure to endosulfan alone at
a dose of 2 mg / kg, reflecting a loss of integrity mitochondrial membranes. Conversely, the
administration of quercetin (10 mg / kg) associated with endosulfan (2mg / kg) was able to
prevent this neuro-mitochondrial toxicity in rats. The in vitro study of the mitochondrial
integrity showed, in the presence of increasing concentrations of endosulfan, a decrease in
absorbance of mitochondrial suspensions, demonstrating that mitochondria were received
massive internalization of water via the opening giant mitochondrial pores (MPTP), causing
them to swell. Inversely, the tubes containing endosulfan and quercetin showed similar
absorbance to the control tube, which provides information on the maintenance of intact
mitochondrial integrity which not allowed undergoing this swelling.
This study also showed a toxic effect on the immune and blood systems through a very
significant increase in the overall number of lymphocytic cells in rats of groups treated with
the mixture endosulfan and naphthalene. It was also found that in the same study, a significant
and very significant respective reduction in granulocytes and monocytes rates. The evaluation
of some blood biochemical parameters did appear impairment of liver function, kidney and
pancreas via the significant increase in transaminases enzymes in the blood serum (TGO and
TGP), cholesterol, triglycerides, urea, creatinin and blood glucose compared to the control
group. Meanwhile, bioactive substances used in these studies, warned the occurrence of these
disturbances in the function of these organs in animals exposed to these persistent organic
products. In conclusion, the results of this present study showed that endosulfan and
naphthalene have neurotoxic power and immunomodulator effect in environmental doses
which have been administered individually or associated in rats. Moreover, it appears that
these persistent organic products significantly alter liver and kidney function.Diplôme : Doctorat en sciences En ligne : ../theses/biologie/ALEK4139.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10310 دراسة الدور الوقائي لبعض المركبات النشطة بيولوجيا اتجاه الأثر السمي للمبيدات الهيدروكربونات على الجهاز العصبي و المناعي عند الجرذان [texte imprimé] / زهورة لقرون, Auteur ; جميلة زعمة, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2016 . - 122 ورقة. ; 30 سم.
2نسخ موجودة مكتبة المركزية
Langues : Arabe (ara)
Catégories : Arabe
5 البيولوجياTags : لمبيدات الهيدروكاربونات الأندوسلفان النفتالين الجهاز العصبي الجهاز المناعي الأثر الوقائي والسمي، المستخلص الخام
لقشور البرتقال فيتامين C فيتامين E الكرستين الميتوكوندريات الإجهاد التأكسديIndex. décimale : 570 بيولوجيا Résumé : Environmental toxicology is nowadays facing a great challenge especially as it is addressing
to study the impact of toxic pollutants on the living organism of the general population, in
contrast to professional pharmacology or toxicology which target limited groups in their
professional and medical milieu with well-known diagnostic and therapeutic approaches.
Indeed, many food biological matrixes are contaminated with pesticides, polycyclic aromatic
hydrocarbons and heavy metals with very little concentrations that we consider such
negligible daily doses but which could accumulate with the time because their solubility in
different organs. This study focuses on the preventive effect of some bioactive compounds
such as vitamin C, vitamin E, quercetin and phenolic extract from orange peel Citrus
Senensis, against the toxic impact of a polycyclic aromatic hydrocarbon, the naphthalene and
endosulfan, as organochlorine pesticide on brain and immune systems. The results showed a
significant change in neuronal redox status in cytosol and brain mitochondria. Indeed,
endosulfan and naphthalene administered alone or in mixture at the respective doses of 2mg /
kg and 50 mg / kg, showed a disturbance in the balance prooxidant / antioxidant in cell
compartmentalization since they caused a significant fall in the level of GSH, GST, SOD and
CAT cytosolic rats treated with these chemicals. The results of these studies have also shown
a significant increase in MDA cytosolic and a highly significant reduction of cytosolic
proteins level was also recorded compared to the control group. Furthermore, the results of
this work have showed a very significant decrease in mitochondrial enzymatic activity of
SOD and CAT parallel to fall of GSH rate. Increased peroxidation was recorded via the
significant increase in mitochondrial MDA following animal exposure to endosulfan alone at
a dose of 2 mg / kg, reflecting a loss of integrity mitochondrial membranes. Conversely, the
administration of quercetin (10 mg / kg) associated with endosulfan (2mg / kg) was able to
prevent this neuro-mitochondrial toxicity in rats. The in vitro study of the mitochondrial
integrity showed, in the presence of increasing concentrations of endosulfan, a decrease in
absorbance of mitochondrial suspensions, demonstrating that mitochondria were received
massive internalization of water via the opening giant mitochondrial pores (MPTP), causing
them to swell. Inversely, the tubes containing endosulfan and quercetin showed similar
absorbance to the control tube, which provides information on the maintenance of intact
mitochondrial integrity which not allowed undergoing this swelling.
This study also showed a toxic effect on the immune and blood systems through a very
significant increase in the overall number of lymphocytic cells in rats of groups treated with
the mixture endosulfan and naphthalene. It was also found that in the same study, a significant
and very significant respective reduction in granulocytes and monocytes rates. The evaluation
of some blood biochemical parameters did appear impairment of liver function, kidney and
pancreas via the significant increase in transaminases enzymes in the blood serum (TGO and
TGP), cholesterol, triglycerides, urea, creatinin and blood glucose compared to the control
group. Meanwhile, bioactive substances used in these studies, warned the occurrence of these
disturbances in the function of these organs in animals exposed to these persistent organic
products. In conclusion, the results of this present study showed that endosulfan and
naphthalene have neurotoxic power and immunomodulator effect in environmental doses
which have been administered individually or associated in rats. Moreover, it appears that
these persistent organic products significantly alter liver and kidney function.Diplôme : Doctorat en sciences En ligne : ../theses/biologie/ALEK4139.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10310 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité لقر/4139 لقر/4139 Thèse Bibliothèque principale Thèses Disponible
Titre : دراسة الدور الوقائي لكل من الفيتامينE وبعض المستخلصات النباتية اتجاه سمية المبيد كلوربيريفوس Type de document : texte imprimé Auteurs : عائشة لطرش, Auteur ; جميلة زعمة, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2011 Importance : 105 ورقة. Note générale : ذكرة ماجيستير
1نسخة موجودة في قاعة المطالعة
2نسخ موجودة في مخزن المكتبة المركزيةLangues : Arabe (ara) Catégories : Arabe
5 البيولوجياIndex. décimale : 570 بيولوجيا En ligne : ../theses/biologie/ATAR3231.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=8599 دراسة الدور الوقائي لكل من الفيتامينE وبعض المستخلصات النباتية اتجاه سمية المبيد كلوربيريفوس [texte imprimé] / عائشة لطرش, Auteur ; جميلة زعمة, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2011 . - 105 ورقة.
ذكرة ماجيستير
1نسخة موجودة في قاعة المطالعة
2نسخ موجودة في مخزن المكتبة المركزية
Langues : Arabe (ara)
Catégories : Arabe
5 البيولوجياIndex. décimale : 570 بيولوجيا En ligne : ../theses/biologie/ATAR3231.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=8599 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité لطر/3231 لطر/3231 Thèse Bibliothèque principale Thèses Disponible 
Titre : دراسة العلاقة ما بين داء الســــــكري التجــــريبي، سمية الإيثانول و المستخلص البيتانولي لنبات Genista quadriflora : دراسة داخــل و خــــارج العضوية. Type de document : texte imprimé Auteurs : نسيمة بوبكري, Auteur ; جميلة زعمة, Directeur de thèse Editeur : constantine [Algérie] : Université Constantine 1 Année de publication : 2014 Importance : 160 ورقة. Format : 30 سم Note générale : 2نسخ موجودة مكتبة المركزية
Langues : Arabe (ara) Catégories : Arabe
5 البيولوجياTags : Genista quadriflora Diabetes Streptozotocin Antioxidant activities lipid peroxidation ethanol Anti-inflammatory Plant extract Phenolic compounds. داء السكري النشاط المضاد للأكسدة الأكسدة الفوقية للدهون الإيثانول المستخلص النباتي مضاد للإلتهاب الفينولات Index. décimale : 570 بيولوجيا Résumé : The present study aims to investigate the hypoglycemic and antioxidant effect of butanol extract of Genista quadriflora plant in experimental diabetic rats. The n-butanol extract of this plant was evaluated in Wistar Albinos rats for anti-inflammatory activity using carrageenan-induced hind paw edema model. Diabetes was induced by streptozotocin (55mg/kg, IV), the butanol extract (200 mg / kg) is administered orally for 6 days before induction of diabetes and 18 days after, the glibenclamide was administed orally at the dose (5 mg / kg) for 18 days. Diabetes was associated with significant increase of: glucose, cholesterol, triglycerides, creatinine, MDA in liver, kidney and pancreas, and decrease in antioxidant enzyme defense system, and induce increased serum transminases. n-butanol extract of Genista quadriflora and glibenclamide significantly decreased the levels of AST, ALT, TBARS, glucose, cholesterol, triglycerides, creatinine and also GSH, significantly elevated the activities of CAT and GPx in liver, kidney and pancreas. Histopathological observations also correlated with the biochemical parameters. Thus, the data indicate that treatment with buthanol extracts of Genista quadriflora offers protection against free radical-mediated oxidative stress in organs of animals with experimental diabetes. Oral treatment with n- butanol extract of Genista quadriflora elicited an inhibitory activity on the development of the paw edema induced by carrageen. This extract showed a significant reduction in the paw edema volume in a dose-dependent.
Excessive ethanol intake induces severe tissue damage particularly in the liver through the generation of reactive oxygen species. This study was designed to examine the effect of n-butanol extract of Genista quadriflora for its protective potentials against ethanol induced toxicity. The effect of n-butanol extract of Genista quadriflora at a dose of 200 mg/kg and 100 mg/kg was studied on ethanol induced hepatic damage (40% v/v, 3 g/kg per oral every 12 hours for 3 doses) in Wistar Albinos rats. Serum transaminases, cholesterol, triglycerides, lipid peroxidation (MDA), reduced glutathione (GSH), glutathione peroxidase (GPx) and catalase were estimated to access liver and kidney damage. A histological study was determined.
It was found that combined Genista quadriflora (200mg/kg) extract and ethanol treatment decreased significantly TBARS level and increased reduced glutathione, glutathione peroxidase, and catalase activities compared to the ethanol group. Results of in vivo experiments showed that the n-butanol extract of Genista quadriflora inhibited lipid peroxidation, protected the experimental animals from hepatic and kidney toxicity and maintained the levels of antioxidants enzymes.
The antioxidant tested In vitro (DPPH scavenging .OH and inhibition of LPO) of extracts of different phases (Phase ethyl acetate; butanol phase) of Genista quadriflora plant extract it indicated that different function as free radical scavengers, such activities are more strongly correlated with the levels of flavonoids and total phenols (Levels flavonoids and total phenols are relatively high).
البيولوجياDiplôme : Doctorat en sciences En ligne : ../theses/biologie/ABOU4028.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=9785 دراسة العلاقة ما بين داء الســــــكري التجــــريبي، سمية الإيثانول و المستخلص البيتانولي لنبات Genista quadriflora : دراسة داخــل و خــــارج العضوية. [texte imprimé] / نسيمة بوبكري, Auteur ; جميلة زعمة, Directeur de thèse . - constantine [Algérie] : Université Constantine 1, 2014 . - 160 ورقة. ; 30 سم.
2نسخ موجودة مكتبة المركزية
Langues : Arabe (ara)
Catégories : Arabe
5 البيولوجياTags : Genista quadriflora Diabetes Streptozotocin Antioxidant activities lipid peroxidation ethanol Anti-inflammatory Plant extract Phenolic compounds. داء السكري النشاط المضاد للأكسدة الأكسدة الفوقية للدهون الإيثانول المستخلص النباتي مضاد للإلتهاب الفينولات Index. décimale : 570 بيولوجيا Résumé : The present study aims to investigate the hypoglycemic and antioxidant effect of butanol extract of Genista quadriflora plant in experimental diabetic rats. The n-butanol extract of this plant was evaluated in Wistar Albinos rats for anti-inflammatory activity using carrageenan-induced hind paw edema model. Diabetes was induced by streptozotocin (55mg/kg, IV), the butanol extract (200 mg / kg) is administered orally for 6 days before induction of diabetes and 18 days after, the glibenclamide was administed orally at the dose (5 mg / kg) for 18 days. Diabetes was associated with significant increase of: glucose, cholesterol, triglycerides, creatinine, MDA in liver, kidney and pancreas, and decrease in antioxidant enzyme defense system, and induce increased serum transminases. n-butanol extract of Genista quadriflora and glibenclamide significantly decreased the levels of AST, ALT, TBARS, glucose, cholesterol, triglycerides, creatinine and also GSH, significantly elevated the activities of CAT and GPx in liver, kidney and pancreas. Histopathological observations also correlated with the biochemical parameters. Thus, the data indicate that treatment with buthanol extracts of Genista quadriflora offers protection against free radical-mediated oxidative stress in organs of animals with experimental diabetes. Oral treatment with n- butanol extract of Genista quadriflora elicited an inhibitory activity on the development of the paw edema induced by carrageen. This extract showed a significant reduction in the paw edema volume in a dose-dependent.
Excessive ethanol intake induces severe tissue damage particularly in the liver through the generation of reactive oxygen species. This study was designed to examine the effect of n-butanol extract of Genista quadriflora for its protective potentials against ethanol induced toxicity. The effect of n-butanol extract of Genista quadriflora at a dose of 200 mg/kg and 100 mg/kg was studied on ethanol induced hepatic damage (40% v/v, 3 g/kg per oral every 12 hours for 3 doses) in Wistar Albinos rats. Serum transaminases, cholesterol, triglycerides, lipid peroxidation (MDA), reduced glutathione (GSH), glutathione peroxidase (GPx) and catalase were estimated to access liver and kidney damage. A histological study was determined.
It was found that combined Genista quadriflora (200mg/kg) extract and ethanol treatment decreased significantly TBARS level and increased reduced glutathione, glutathione peroxidase, and catalase activities compared to the ethanol group. Results of in vivo experiments showed that the n-butanol extract of Genista quadriflora inhibited lipid peroxidation, protected the experimental animals from hepatic and kidney toxicity and maintained the levels of antioxidants enzymes.
The antioxidant tested In vitro (DPPH scavenging .OH and inhibition of LPO) of extracts of different phases (Phase ethyl acetate; butanol phase) of Genista quadriflora plant extract it indicated that different function as free radical scavengers, such activities are more strongly correlated with the levels of flavonoids and total phenols (Levels flavonoids and total phenols are relatively high).
البيولوجياDiplôme : Doctorat en sciences En ligne : ../theses/biologie/ABOU4028.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=9785 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité بوب/4028 بوب/4028 Thèse Bibliothèque principale Thèses Disponible Documents numériques
texte intégreURL
texte intégreAdobe Acrobat PDF
Titre : دور المستخلص البيتانولي لنباتين من جنس) (Genista et Limoniumفي الوقاية من سمية مبيد الكلوربيريفوس Type de document : texte imprimé Auteurs : عائشة لطرش, Auteur ; جميلة زعمة, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2018 Importance : 141 ورقة. Format : 30 سم. Note générale : 2نسخ موجودة مكتبة المركزية
Langues : Arabe (ara) Catégories : Arabe
5 البيولوجياTags : Chlorpyrifos Oxidative stress, Lipid peroxidation Plant extract Flavonoids,AchE Limonium pruinosum Genista ulicina Flavonoids مبيد الكلوربيريفوس التوتر التأكسدي الأكسدة اللبيدية المستخلصات النباتية الفلافونويدات الاستيل كولين استراز Index. décimale : 570 بيولوجيا Résumé : Although mostly known as an organophosphorus pesticides (OPs) Chlorpyrifos (CPF) can react also as a pro-oxidant resulting in the generation of (ROS) (Reactive oxygen species).
The purpose of this study was to evaluate the protective effect of Genista ulicina Spach and Limonium pruinosum extract Towards the oxidative stress which implied (involved) in the toxicity of this pesticide.
Our result indicated that administration of CPF at a dose (10mg/kg/BW) for 10 days by oral gavage induced a significant increase in MDA level in all tissues, organs; transaminase enzymes ALAT, ASAT; Triglycerides,cholesterol, Creatinine and Uric Acid; on the other hand the activity of antioxidant enzyme including GPx, CAT and GSH levels were significantly decreased. Histopathological observations also correlated with the biochemical parameters was shown.
Also, the protective effects of Buthanolic extract of Genista ulicina Spach and Limonium pruinosum (150mg/kg/BW) alone or in combination with CPF were investigated. Co-administration of plants extract with CPF or alone in male rats decreased MDA levels, normalized CAT and GPx activity as well as GSH content and restore some biochemical parameters by suppressing CPF
stress. Furthermore Milder pathological alterations were observed. Overall, the protective effects of plants extract on CPF induced toxicity may be due to its potent antioxidative properties Antioxidant activities of the extracts were studied in vitro. The inhibition
of the formation of malondialdehyde (MDA) and the scavenging of DPPH radicals were assayed. The total phenolic and flavonoid contents of the extracts were determined. The experimental results show that the extracts had antioxidant activity in vitro. The extracts showed a high antioxidant effect, especially scavenging of DPPH anions and inhibition of lipid peroxidation.
That extracts can inhibit membrane LPO and free radical formation due to its free radical scavenging ability. The biological and antioxidant effects exhibited by these extracts could be related to an overall effect of the phenolic compounds present in this extract .Leading to ensure a protective role in attenuating the oxidative stress generated by CPF.
Diplôme : Doctorat en sciences En ligne : ../theses/biologie/ALAT4337.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10943 دور المستخلص البيتانولي لنباتين من جنس) (Genista et Limoniumفي الوقاية من سمية مبيد الكلوربيريفوس [texte imprimé] / عائشة لطرش, Auteur ; جميلة زعمة, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2018 . - 141 ورقة. ; 30 سم.
2نسخ موجودة مكتبة المركزية
Langues : Arabe (ara)
Catégories : Arabe
5 البيولوجياTags : Chlorpyrifos Oxidative stress, Lipid peroxidation Plant extract Flavonoids,AchE Limonium pruinosum Genista ulicina Flavonoids مبيد الكلوربيريفوس التوتر التأكسدي الأكسدة اللبيدية المستخلصات النباتية الفلافونويدات الاستيل كولين استراز Index. décimale : 570 بيولوجيا Résumé : Although mostly known as an organophosphorus pesticides (OPs) Chlorpyrifos (CPF) can react also as a pro-oxidant resulting in the generation of (ROS) (Reactive oxygen species).
The purpose of this study was to evaluate the protective effect of Genista ulicina Spach and Limonium pruinosum extract Towards the oxidative stress which implied (involved) in the toxicity of this pesticide.
Our result indicated that administration of CPF at a dose (10mg/kg/BW) for 10 days by oral gavage induced a significant increase in MDA level in all tissues, organs; transaminase enzymes ALAT, ASAT; Triglycerides,cholesterol, Creatinine and Uric Acid; on the other hand the activity of antioxidant enzyme including GPx, CAT and GSH levels were significantly decreased. Histopathological observations also correlated with the biochemical parameters was shown.
Also, the protective effects of Buthanolic extract of Genista ulicina Spach and Limonium pruinosum (150mg/kg/BW) alone or in combination with CPF were investigated. Co-administration of plants extract with CPF or alone in male rats decreased MDA levels, normalized CAT and GPx activity as well as GSH content and restore some biochemical parameters by suppressing CPF
stress. Furthermore Milder pathological alterations were observed. Overall, the protective effects of plants extract on CPF induced toxicity may be due to its potent antioxidative properties Antioxidant activities of the extracts were studied in vitro. The inhibition
of the formation of malondialdehyde (MDA) and the scavenging of DPPH radicals were assayed. The total phenolic and flavonoid contents of the extracts were determined. The experimental results show that the extracts had antioxidant activity in vitro. The extracts showed a high antioxidant effect, especially scavenging of DPPH anions and inhibition of lipid peroxidation.
That extracts can inhibit membrane LPO and free radical formation due to its free radical scavenging ability. The biological and antioxidant effects exhibited by these extracts could be related to an overall effect of the phenolic compounds present in this extract .Leading to ensure a protective role in attenuating the oxidative stress generated by CPF.
Diplôme : Doctorat en sciences En ligne : ../theses/biologie/ALAT4337.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10943 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité لطر/4337 لطر/4337 Thèse Bibliothèque principale Thèses Disponible
