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Auteur Djamila Zama |
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Affiner la recherche Interroger des sources externesL'effet préventif des flavonoïdes et des phénols de thé vert (Camellia sinensis (L.) Kuntze) sur le cancer de la prostate chez une population de l'Est Algérien / Somia Lassed
Titre : L'effet préventif des flavonoïdes et des phénols de thé vert (Camellia sinensis (L.) Kuntze) sur le cancer de la prostate chez une population de l'Est Algérien : étude épidémiologique et étude expérimentale in vitro et in humaine Type de document : texte imprimé Auteurs : Somia Lassed, Auteur ; Djamila Zama, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2017 Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : Cancer de la prostate stress oxydant thé vert chimioprévention Algérie Prostate cancer oxidative stress green tea chemoprevention Algeria سرطان البروستاتا الإجھاد التأكسدي الشاي الأخضر الوقایة الكیماویة الجزائر Index. décimale : 570 Sciences de la vie. Biologie Résumé : In Algeria, prostate cancer is the fourth most common cancer and the sixth leading cause of
death in men. The objective of the current study is to determine the relationship between lifestyle
factors, family history, diet including green tea consumption and the risk of prostate cancer and to
evaluate the preventive effect of green tea on prostate cancer in the East Algerian population.
The epidemiological approach carried out on a representative sample of East Algerian
population consists of 90 patients with prostate cancer and 190 controls shows that ageing,
consumption of lamb and beef and high intake of animal fat and dairy products increase the risk
of prostate cancer. Contrary, 7 to 13 servings of vegetables per week and 14 servings or more
decrease 62% and 96% of the risk of prostate cancer respectively. Also, the consumption of 7 to
14 servings of fruit per week decreases 98% of the risk. Consumption of green tea reduced the
risk of prostate cancer, but the results were statistically limited. A high risk has been observed in
men with a family history of prostate cancer. A positive association was also found for alcohol
and smoking intake and a dose-response relationship existed for quantity and history of smoking.
Our intervention study include 70 patients with prostate cancer and 120 controls of East Algerian
population and which precedes by an in vitro study shows that oxidative stress can be associated
with the development and progression of prostate cancer in our population. Also, the consumption
of green tea which is rich in phenols and flavonoids and which exhibits potent antioxidant and
anti-cancer activities in our in vitro study can have a protective effect against this disease via the
reduction of oxidative stress. Consumption of 2 to 3 cups of green tea per day for 6 months
significantly increases the level of GSH, total thiols and catalase and GPx activity and
significantly decreases the level of MDA in the blood of patients with prostate cancer. In addition
it also improves the level of albumin and total protein in plasma.
Faced to the limitations of the treatments currently used for cancer, chemoprevention remains
the only solution. Regular consumption of green tea for a long period may prevent men from
developing prostate cancer or at least delay its progression.Diplôme : Doctorat En ligne : ../theses/biologie/LAS7067.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10534 L'effet préventif des flavonoïdes et des phénols de thé vert (Camellia sinensis (L.) Kuntze) sur le cancer de la prostate chez une population de l'Est Algérien : étude épidémiologique et étude expérimentale in vitro et in humaine [texte imprimé] / Somia Lassed, Auteur ; Djamila Zama, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2017.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Cancer de la prostate stress oxydant thé vert chimioprévention Algérie Prostate cancer oxidative stress green tea chemoprevention Algeria سرطان البروستاتا الإجھاد التأكسدي الشاي الأخضر الوقایة الكیماویة الجزائر Index. décimale : 570 Sciences de la vie. Biologie Résumé : In Algeria, prostate cancer is the fourth most common cancer and the sixth leading cause of
death in men. The objective of the current study is to determine the relationship between lifestyle
factors, family history, diet including green tea consumption and the risk of prostate cancer and to
evaluate the preventive effect of green tea on prostate cancer in the East Algerian population.
The epidemiological approach carried out on a representative sample of East Algerian
population consists of 90 patients with prostate cancer and 190 controls shows that ageing,
consumption of lamb and beef and high intake of animal fat and dairy products increase the risk
of prostate cancer. Contrary, 7 to 13 servings of vegetables per week and 14 servings or more
decrease 62% and 96% of the risk of prostate cancer respectively. Also, the consumption of 7 to
14 servings of fruit per week decreases 98% of the risk. Consumption of green tea reduced the
risk of prostate cancer, but the results were statistically limited. A high risk has been observed in
men with a family history of prostate cancer. A positive association was also found for alcohol
and smoking intake and a dose-response relationship existed for quantity and history of smoking.
Our intervention study include 70 patients with prostate cancer and 120 controls of East Algerian
population and which precedes by an in vitro study shows that oxidative stress can be associated
with the development and progression of prostate cancer in our population. Also, the consumption
of green tea which is rich in phenols and flavonoids and which exhibits potent antioxidant and
anti-cancer activities in our in vitro study can have a protective effect against this disease via the
reduction of oxidative stress. Consumption of 2 to 3 cups of green tea per day for 6 months
significantly increases the level of GSH, total thiols and catalase and GPx activity and
significantly decreases the level of MDA in the blood of patients with prostate cancer. In addition
it also improves the level of albumin and total protein in plasma.
Faced to the limitations of the treatments currently used for cancer, chemoprevention remains
the only solution. Regular consumption of green tea for a long period may prevent men from
developing prostate cancer or at least delay its progression.Diplôme : Doctorat En ligne : ../theses/biologie/LAS7067.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10534 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité LAS/7067 LAS/7067 Thèse Bibliothèque principale Thèses Disponible
Titre : L’effet protecteur des extraits de la plante Centaurea sphaerocephala L. vis-à-vis de la toxicité induite par l’acide valproïque : Etude in vitro et in vivo Type de document : texte imprimé Auteurs : Amina Maya Lahneche, Auteur ; Djamila Zama, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2018 Importance : 140 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : Centaurea sphaerocephala l’acide valproïque stress oxydative activités antioxydantes composés phénoliques oxidative stress valproic acid antioxidant activities lipid
peroxidation plant extract phenolic compounds التوتر التأكسدي الفعل المضاد للأكسدة المستخلص النباتي المركبات الفينولية الأكسدة الفوقية للدهونIndex. décimale : 570 Sciences de la vie. Biologie Résumé : This work is devoted to study the protective effect of n-butanol extract of Centaurea sphaerocephala (c. sphaerocephala) against the impact toxic of valproic acid (VPA) associated with oxidative stress on different tissues in male Wistar albino’s rats. For that, n-Butanol extract of C. sphaerocephala (50mg/kg and 100mg/kg) and VPA (300mg/kg) were administered by gavage for 14days. At the end of the experiment or in the 15th day, animals were scarified, dissected and different organs (liver, kidney, brain and testicular) were removed, homogenized and used for determination of lipid peroxidation and antioxidant enzymes (catalase (CAT), glutathione peroxidase (GPx) and the level of reduced glutathione (GSH)). A small species of these organs were used for histopathological examination.
The dysfunction caused by the VPA is expressed by a significant increase of lipid peroxidation reported by a determination of the level of tissues MDA and a significant decrease in GSH level and activity of enzymes antioxidant enzymes activities (catalase and GPx). This accompanied by a changes in biochemical parameters characterized especially by an increase in the concentration of creatinine, blood sugar, cholesterol levels, triglycerides and Aminotransferase (AST, ALT) which are released once that liver cells damaged and their membrane perforated.
As well, the histological’ results showed clear alterations in the histoarchitecture of the different tissues studied: liver, kidney and testicular.
Indeed, the pretreatment of rats by n-butanolic extract of C. sphaerocephala (50mg/kg, 100mg/kg) and Vit E (100mg/kg) restored the biochemical parameters to their normal values and also improved the antioxidant parameters as well as the histological appearance of the different tissues studied.
n-butanol extract of this plant has a protective effect action against the oxidative stress resulting from the treatment of rats by the VPA due to its antioxidant effect.
The in vitro Antioxidant tests (scavenging the radical DPPH, inhibition of LPO,) of the extracts the different phases (ethyl acetate and n-butanol) of C. Sphaerocephala indicated that various extracts have the role of free radical’s scavengers. In addition, these activities are strongly correlated with the levels of flavonoids and total phenols which are relatively high.
The anticancer test was carried out using (HeLa) cell line by analyzing the different doses of the n-butanol extract of C. sphaerocephala plant. The results indicate that the extract has an anti-cancer effect concentrations dependent.
Diplôme : Doctorat En ligne : ../theses/biologie/LAH7238.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10833 L’effet protecteur des extraits de la plante Centaurea sphaerocephala L. vis-à-vis de la toxicité induite par l’acide valproïque : Etude in vitro et in vivo [texte imprimé] / Amina Maya Lahneche, Auteur ; Djamila Zama, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2018 . - 140 f. ; 30 cm.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Centaurea sphaerocephala l’acide valproïque stress oxydative activités antioxydantes composés phénoliques oxidative stress valproic acid antioxidant activities lipid
peroxidation plant extract phenolic compounds التوتر التأكسدي الفعل المضاد للأكسدة المستخلص النباتي المركبات الفينولية الأكسدة الفوقية للدهونIndex. décimale : 570 Sciences de la vie. Biologie Résumé : This work is devoted to study the protective effect of n-butanol extract of Centaurea sphaerocephala (c. sphaerocephala) against the impact toxic of valproic acid (VPA) associated with oxidative stress on different tissues in male Wistar albino’s rats. For that, n-Butanol extract of C. sphaerocephala (50mg/kg and 100mg/kg) and VPA (300mg/kg) were administered by gavage for 14days. At the end of the experiment or in the 15th day, animals were scarified, dissected and different organs (liver, kidney, brain and testicular) were removed, homogenized and used for determination of lipid peroxidation and antioxidant enzymes (catalase (CAT), glutathione peroxidase (GPx) and the level of reduced glutathione (GSH)). A small species of these organs were used for histopathological examination.
The dysfunction caused by the VPA is expressed by a significant increase of lipid peroxidation reported by a determination of the level of tissues MDA and a significant decrease in GSH level and activity of enzymes antioxidant enzymes activities (catalase and GPx). This accompanied by a changes in biochemical parameters characterized especially by an increase in the concentration of creatinine, blood sugar, cholesterol levels, triglycerides and Aminotransferase (AST, ALT) which are released once that liver cells damaged and their membrane perforated.
As well, the histological’ results showed clear alterations in the histoarchitecture of the different tissues studied: liver, kidney and testicular.
Indeed, the pretreatment of rats by n-butanolic extract of C. sphaerocephala (50mg/kg, 100mg/kg) and Vit E (100mg/kg) restored the biochemical parameters to their normal values and also improved the antioxidant parameters as well as the histological appearance of the different tissues studied.
n-butanol extract of this plant has a protective effect action against the oxidative stress resulting from the treatment of rats by the VPA due to its antioxidant effect.
The in vitro Antioxidant tests (scavenging the radical DPPH, inhibition of LPO,) of the extracts the different phases (ethyl acetate and n-butanol) of C. Sphaerocephala indicated that various extracts have the role of free radical’s scavengers. In addition, these activities are strongly correlated with the levels of flavonoids and total phenols which are relatively high.
The anticancer test was carried out using (HeLa) cell line by analyzing the different doses of the n-butanol extract of C. sphaerocephala plant. The results indicate that the extract has an anti-cancer effect concentrations dependent.
Diplôme : Doctorat En ligne : ../theses/biologie/LAH7238.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10833 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité LAH/7238 LAH/7238 Thèse Bibliothèque principale Thèses Disponible
Titre : L’effet protecteur des extraits des plantes Helianthemum confertum et Helianthemum ruficomum vis-à-vis de la toxicité induite par la Doxorubicine : Etude in vitro et in vivo Type de document : texte imprimé Auteurs : Radja Djebbari, Auteur ; Djamila Zama, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2017 Importance : 122 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles.
Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : Helianthemum confertum Helianthemum ruficomum stress oxydative activités anti oxydants Doxorubicine extraits des plantes peroxydation lipidique composes phénoliques oxidative stress Doxorubicin Antioxidant activities lipid peroxidation Plant extract Phenolic compounds Doxorubicineالمستخلص النباتي الفينولات النشاط المضاد للأكسدة التوترالتاكسدي الأكسدة الفوقية للدهون Index. décimale : 570 Sciences de la vie. Biologie Résumé : The present study aims to investigate the protective and antioxidant effects of n-butanol extracts of H. confertum and H. ruficomum plants in experimental rats. The n-butanol extract of those plants was evaluated in Wistar Albinos rats for its protective potentials against doxorubicin induced acute toxicity. The effect of n-butanol extracts of H. confertum and H. ruficomum at a dose of (50mg/kg and 100mg/kg) was studied on DOX-induced hepatic, kidney and heart damage. One dose of doxorubicin (10mg/kg and 15mg/kg) was injected intraperitoneal in Wistar Albinos rats. Serum transaminases, cholesterol, triglycerides, LDH, urea, creatinine, lipid peroxidation (MDA), reduced glutathione (GSH), glutathione peroxidase (GPx) and catalase were estimated to access liver, kidney and heart damage. It was found that combined H.
confertum and H. ruficomum (50 and 100mg/kg) extract and DOX (10 and15mg/kg) treatment decreased significantly TBARS level and biochemical parameters. In contract increased reduced glutathione, glutathione peroxidase, and catalase activities compared to the DOX-group. Results of in vivo experiments showed that the n-butanol extracts of H. confertum and H. ruficomum inhibited lipid peroxidation, protected the experimental animals from hepatic and kidney toxicity
and maintained the levels of antioxidants enzymes. The protective effect of vitamin E was also studied against doxorubicin-induced acute toxicity at (15mg/kg), and it was found that combined vitamin E (100mg/kg) and DOX (15mg/kg) treatment decreased significantly TBARS level and increased antioxidants activities.
Also, histological study was determined in pretreatment with n-butanol extract of H. confertum and doxorubicin induced acute toxicity at (10mg/kg), and it was found that combined H. confertum n-butanol extract at (50 and 100mg/kg) decreased necrotic cells in hepatic tissue. The antioxidant in vitro tests (DPPH scavenging, inhibition of LPO and anti-cancer activity) of n-butanol extracts of H. confertum and H. ruficomum indicated that different function as free radical scavengers, such activities are more strongly correlated with the levels of flavonoids and total phenols.Diplôme : Doctorat En ligne : ../theses/biologie/DJE7167.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10590 L’effet protecteur des extraits des plantes Helianthemum confertum et Helianthemum ruficomum vis-à-vis de la toxicité induite par la Doxorubicine : Etude in vitro et in vivo [texte imprimé] / Radja Djebbari, Auteur ; Djamila Zama, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2017 . - 122 f. ; 30 cm.
2 copies imprimées disponibles.
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Helianthemum confertum Helianthemum ruficomum stress oxydative activités anti oxydants Doxorubicine extraits des plantes peroxydation lipidique composes phénoliques oxidative stress Doxorubicin Antioxidant activities lipid peroxidation Plant extract Phenolic compounds Doxorubicineالمستخلص النباتي الفينولات النشاط المضاد للأكسدة التوترالتاكسدي الأكسدة الفوقية للدهون Index. décimale : 570 Sciences de la vie. Biologie Résumé : The present study aims to investigate the protective and antioxidant effects of n-butanol extracts of H. confertum and H. ruficomum plants in experimental rats. The n-butanol extract of those plants was evaluated in Wistar Albinos rats for its protective potentials against doxorubicin induced acute toxicity. The effect of n-butanol extracts of H. confertum and H. ruficomum at a dose of (50mg/kg and 100mg/kg) was studied on DOX-induced hepatic, kidney and heart damage. One dose of doxorubicin (10mg/kg and 15mg/kg) was injected intraperitoneal in Wistar Albinos rats. Serum transaminases, cholesterol, triglycerides, LDH, urea, creatinine, lipid peroxidation (MDA), reduced glutathione (GSH), glutathione peroxidase (GPx) and catalase were estimated to access liver, kidney and heart damage. It was found that combined H.
confertum and H. ruficomum (50 and 100mg/kg) extract and DOX (10 and15mg/kg) treatment decreased significantly TBARS level and biochemical parameters. In contract increased reduced glutathione, glutathione peroxidase, and catalase activities compared to the DOX-group. Results of in vivo experiments showed that the n-butanol extracts of H. confertum and H. ruficomum inhibited lipid peroxidation, protected the experimental animals from hepatic and kidney toxicity
and maintained the levels of antioxidants enzymes. The protective effect of vitamin E was also studied against doxorubicin-induced acute toxicity at (15mg/kg), and it was found that combined vitamin E (100mg/kg) and DOX (15mg/kg) treatment decreased significantly TBARS level and increased antioxidants activities.
Also, histological study was determined in pretreatment with n-butanol extract of H. confertum and doxorubicin induced acute toxicity at (10mg/kg), and it was found that combined H. confertum n-butanol extract at (50 and 100mg/kg) decreased necrotic cells in hepatic tissue. The antioxidant in vitro tests (DPPH scavenging, inhibition of LPO and anti-cancer activity) of n-butanol extracts of H. confertum and H. ruficomum indicated that different function as free radical scavengers, such activities are more strongly correlated with the levels of flavonoids and total phenols.Diplôme : Doctorat En ligne : ../theses/biologie/DJE7167.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=10590 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité DJE/7167 DJE/7167 Thèse Bibliothèque principale Thèses Disponible
Titre : L’effet protecteur des extraits des plantes (Perralderia coronopifolia et Gaillonia reboudiana) vis-à-vis d’une toxicité provoquée par le pentachlorophénol. Type de document : texte imprimé Auteurs : Khadidja Bekhouche, Auteur ; Djamila Zama, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2019 Importance : 285 f. Format : 30 cm. Note générale : Doctorat 3éme CYCLE LMD.
2 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : Biologie Animale: Physiotoxicologie Cellulaire Perralderia coronopifolia Gaillonia reboudiana Pentachlorophénol Polyphénols Activité
antioxydante Activité anticancéreuse Hépato-toxicité Pentachlorophenol Polyphenols Antioxidant activity anticancer activity Hepatotoxicity نشاط مضاد للأكسدة فينول خماسي الكلور سمية كبدية نشاط مضاد للسرطانIndex. décimale : 570 Sciences de la vie. Biologie Résumé :
The present study was conducted to evaluate the protective effects and biological properties of the two endemic plants P. coronopifolia and G. reboudiana. The ethyl acetate acetate and nbutanol extracts of the P. coronopifolia plant as well as the metanolic extract of the G. reboudiana plant show richness in phenolic compounds and particularly flavonoids. These compounds provided a very important total antioxidant activity compared to standards antioxidant. This activity is justified in vitro by the reducing power and the large trapping capacity of the ROS, metal chelation, inhibition of lipid peroxidation, and plasmid DNA protection against oxidative damage induced by ROS. Thus, a potent antiproliferative activity of higher concentration has been proven in our various extracts, and especially in the extracts examined from the plant P. coronopifolia against the C6 and HeLa cancer cell lines. Another study was carried out in order to prove the in vivo antioxidant effect and the protective effect of these extracts against functional and structural alterations in livers, kidneys and hearts following PCP-induced toxicity in adult rats (with a dose of 20 mg / kg/ day during two weeks). These extracts act on the maintenance of the antioxidant system against xenobiotics. In addition, PCP treatment caused damage to the electrical system in cells membranes via a significant increase in MDA levels, a decreased GPx activity, a decreased GSH levels and a significant disruption of serum biochemical parameters (increased levels of AST, ALT, total bilirubin, urea, creatine, cholesterol and triglycerides). Pre-treatment of rats with n-butanol extracts of the P. coronopifolia plant and metanolic extract of the G. reboudiana showed that they are able to normalize the MDA reduced glutathione levels and GPx activities (of liver, kidney and heart) and capable to regularise the biochemical parameters in serums of PCP-treated rats. Pretreatment with these extracts has shown that they can act as radical chain terminators that converts reactive free radicals into stable, non-reactive products, and also as chemo-protectors against cellular oxidative damage (in liver, kidney and heart cells) induced by the PCP-treatment. Following our in vitro and in vivo studies, a histological study was carried out to confirm their protective effects against PCP-induced toxicity, by protecting the architecture of liver, kidney and heart and decreasing the functional and structural alterations of these organs. Our extracts showed strong antioxidant activity, DNA-protective capacity, high-potency anticancer effects and protective effects against PCP-induced toxicity in Witar Albinos rats.Note de contenu : Annexes. Diplôme : Doctorat En ligne : ../theses/biologie/BEK7536.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11376 L’effet protecteur des extraits des plantes (Perralderia coronopifolia et Gaillonia reboudiana) vis-à-vis d’une toxicité provoquée par le pentachlorophénol. [texte imprimé] / Khadidja Bekhouche, Auteur ; Djamila Zama, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2019 . - 285 f. ; 30 cm.
Doctorat 3éme CYCLE LMD.
2 copies imprimées disponibles
Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : Biologie Animale: Physiotoxicologie Cellulaire Perralderia coronopifolia Gaillonia reboudiana Pentachlorophénol Polyphénols Activité
antioxydante Activité anticancéreuse Hépato-toxicité Pentachlorophenol Polyphenols Antioxidant activity anticancer activity Hepatotoxicity نشاط مضاد للأكسدة فينول خماسي الكلور سمية كبدية نشاط مضاد للسرطانIndex. décimale : 570 Sciences de la vie. Biologie Résumé :
The present study was conducted to evaluate the protective effects and biological properties of the two endemic plants P. coronopifolia and G. reboudiana. The ethyl acetate acetate and nbutanol extracts of the P. coronopifolia plant as well as the metanolic extract of the G. reboudiana plant show richness in phenolic compounds and particularly flavonoids. These compounds provided a very important total antioxidant activity compared to standards antioxidant. This activity is justified in vitro by the reducing power and the large trapping capacity of the ROS, metal chelation, inhibition of lipid peroxidation, and plasmid DNA protection against oxidative damage induced by ROS. Thus, a potent antiproliferative activity of higher concentration has been proven in our various extracts, and especially in the extracts examined from the plant P. coronopifolia against the C6 and HeLa cancer cell lines. Another study was carried out in order to prove the in vivo antioxidant effect and the protective effect of these extracts against functional and structural alterations in livers, kidneys and hearts following PCP-induced toxicity in adult rats (with a dose of 20 mg / kg/ day during two weeks). These extracts act on the maintenance of the antioxidant system against xenobiotics. In addition, PCP treatment caused damage to the electrical system in cells membranes via a significant increase in MDA levels, a decreased GPx activity, a decreased GSH levels and a significant disruption of serum biochemical parameters (increased levels of AST, ALT, total bilirubin, urea, creatine, cholesterol and triglycerides). Pre-treatment of rats with n-butanol extracts of the P. coronopifolia plant and metanolic extract of the G. reboudiana showed that they are able to normalize the MDA reduced glutathione levels and GPx activities (of liver, kidney and heart) and capable to regularise the biochemical parameters in serums of PCP-treated rats. Pretreatment with these extracts has shown that they can act as radical chain terminators that converts reactive free radicals into stable, non-reactive products, and also as chemo-protectors against cellular oxidative damage (in liver, kidney and heart cells) induced by the PCP-treatment. Following our in vitro and in vivo studies, a histological study was carried out to confirm their protective effects against PCP-induced toxicity, by protecting the architecture of liver, kidney and heart and decreasing the functional and structural alterations of these organs. Our extracts showed strong antioxidant activity, DNA-protective capacity, high-potency anticancer effects and protective effects against PCP-induced toxicity in Witar Albinos rats.Note de contenu : Annexes. Diplôme : Doctorat En ligne : ../theses/biologie/BEK7536.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11376 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité BEK/7536 BEK/7536 Thèse Bibliothèque principale Thèses Disponible
Titre : Etude phytochimique et pharmacologique de deux plantes appartenant à la famille des Astéraceae et Fabaceae. : Cas de : Onopordum acanthium L. et Spartium junceum L. Type de document : texte imprimé Auteurs : Sofiane Habibatni, Auteur ; Djamila Zama, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2018 Importance : 107 f. Format : 30 cm. Note générale : 0 copies imprimées disponibles
Langues : Français (fre) Catégories : Français - Anglais
BiologieTags : d’O acanthium S junceum Extrait BuOH Activité antioxydante Activité analgésique oedémateuse et antipyéritique O acanthium Antioxidant activity Analgesic edematous and antipyretic activity S junceum O acanthiumمستخلص BuOHنشاط مضاد للأكسدة نشاط مسكن الاذمة وخافض للحرارة Index. décimale : 570 Sciences de la vie. Biologie Résumé : The present work was focused on the phytochemical analytical studies and the evaluation of antioxidant and anti-inflammatory activities including analgesic and antipyretic activity of two plants belonging to asteraceae and fabaceae families namely O. acanthium and S. junceum. The various preparations of O. acanthium are mainly used against hepatic diseases, hemorrhoids, gastric disorders, gynecological diseases and as antipyretic. While those of S. junceum are cardiotonic, cathartic, diuretic, emetic and purgative. Phytochemical analysis of various parts of both the plants revealed the presence of phenols, flavonoïds, saponins, coumarins, tannins and anthraquinones. Onopordum and Spartium acetate extract had shown strongest antioxidant activity analysed with the DPPH test with IC50 values of 16.19 and 24.32 μg / mL respectively.With the ABTS+ radical cation reduction test, the acetate extract of the Onopordum and Spartium ethanolic flowers displayed IC50 values of 23.71 and 23.49 μg / mL respectively. With the ß-carotene bleaching test, the acetate extract and dichloromethane extract of O. acanthium flowers had IC50 equal to 2.51 and 20.77 respectively whereas the acetate extract of S. junceum had IC50 equal to 24.28 μg / mL. With iron reduction test, antioxidant activity of O. acanthium flowers of acetate extract followed by dichloromethane extract with IC50 value 6.48 and 10.08 respectively whereas butanolic extract of S. junceum leaves and acetate extract of S. junceum flowers showed very interesting activity with IC50 value 13.15 and 14.52 respectively. These extracts have the power to reduce Fe. An in-vivo study have shown an analgesic activity for the BuOH extract of the leaves and stems of O acanthium and S junceum respectively, with a notorious power of protection against abdominal cramps, at the dose of 600 mg / kg, after 25 min pretreatment with BuOH extracts of O acanthium and S junceum had a protective effect against pain comparable to that of aspirin at a dose of 500 mg / kg. The results obtained shown that the butanolic extracts of the two plants at the dose of 900 mg / kg had superior anti-inflammatory activity and highly significant to that of aspirin at 500 mg / kg. In addition, the BuOH extract of O acanthium leaves showed an anti-inflammatory and antipyretic effect. These results demonstrates as a starting point for therapeutic applications.
Diplôme : Doctorat en sciences En ligne : ../theses/biologie/HAB7375.pdf Format de la ressource électronique : Permalink : index.php?lvl=notice_display&id=11024 Etude phytochimique et pharmacologique de deux plantes appartenant à la famille des Astéraceae et Fabaceae. : Cas de : Onopordum acanthium L. et Spartium junceum L. [texte imprimé] / Sofiane Habibatni, Auteur ; Djamila Zama, Directeur de thèse . - جامعة الإخوة منتوري قسنطينة, 2018 . - 107 f. ; 30 cm.
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Langues : Français (fre)
Catégories : Français - Anglais
BiologieTags : d’O acanthium S junceum Extrait BuOH Activité antioxydante Activité analgésique oedémateuse et antipyéritique O acanthium Antioxidant activity Analgesic edematous and antipyretic activity S junceum O acanthiumمستخلص BuOHنشاط مضاد للأكسدة نشاط مسكن الاذمة وخافض للحرارة Index. décimale : 570 Sciences de la vie. Biologie Résumé : The present work was focused on the phytochemical analytical studies and the evaluation of antioxidant and anti-inflammatory activities including analgesic and antipyretic activity of two plants belonging to asteraceae and fabaceae families namely O. acanthium and S. junceum. The various preparations of O. acanthium are mainly used against hepatic diseases, hemorrhoids, gastric disorders, gynecological diseases and as antipyretic. While those of S. junceum are cardiotonic, cathartic, diuretic, emetic and purgative. Phytochemical analysis of various parts of both the plants revealed the presence of phenols, flavonoïds, saponins, coumarins, tannins and anthraquinones. Onopordum and Spartium acetate extract had shown strongest antioxidant activity analysed with the DPPH test with IC50 values of 16.19 and 24.32 μg / mL respectively.With the ABTS+ radical cation reduction test, the acetate extract of the Onopordum and Spartium ethanolic flowers displayed IC50 values of 23.71 and 23.49 μg / mL respectively. With the ß-carotene bleaching test, the acetate extract and dichloromethane extract of O. acanthium flowers had IC50 equal to 2.51 and 20.77 respectively whereas the acetate extract of S. junceum had IC50 equal to 24.28 μg / mL. With iron reduction test, antioxidant activity of O. acanthium flowers of acetate extract followed by dichloromethane extract with IC50 value 6.48 and 10.08 respectively whereas butanolic extract of S. junceum leaves and acetate extract of S. junceum flowers showed very interesting activity with IC50 value 13.15 and 14.52 respectively. These extracts have the power to reduce Fe. An in-vivo study have shown an analgesic activity for the BuOH extract of the leaves and stems of O acanthium and S junceum respectively, with a notorious power of protection against abdominal cramps, at the dose of 600 mg / kg, after 25 min pretreatment with BuOH extracts of O acanthium and S junceum had a protective effect against pain comparable to that of aspirin at a dose of 500 mg / kg. The results obtained shown that the butanolic extracts of the two plants at the dose of 900 mg / kg had superior anti-inflammatory activity and highly significant to that of aspirin at 500 mg / kg. In addition, the BuOH extract of O acanthium leaves showed an anti-inflammatory and antipyretic effect. These results demonstrates as a starting point for therapeutic applications.
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