4 résultat(s) recherche sur le tag 'antioxidants'    

Enquête sur la consommation des polyphénols auprès d’un échantillon de 200 personnes de la région de Constantine / Fatima Zohra Becila    

Public ISBD Titre : Enquête sur la consommation des polyphénols auprès d’un échantillon de 200 personnes de la région de Constantine Type de document : texte imprimé Auteurs : Fatima Zohra Becila, Auteur ; Malika Barkat, Directeur de thèse Editeur : constantine [Algérie] : Université Constantine 1 Année de publication : 2014 Importance : 104 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles Langues : Français (fre) Tags : Free radicals  oxidative stress  antioxidants  polyphenols  health  nutrition  radicaux libres  apport journalier  polyphénols  santé  alimentation  ?????? ?????  ???????  ?????? ???????  ????? ?????????  ????? Index. décimale : 640 Industrie Alimentaire Résumé : The organism produces free radicals daily. They may result from the action of certain chemical components of our environment (X-rays and UV light) of air pollutants (N, NO2), drugs, smoke, tobacco, alcohol, dietary errors. Oxidative stress due to free radicals causes tissue damage mainly by oxidation of proteins, DNA or lipids; it is involved in many diseases such as trigger or associated with the development of complications. Antioxidants are compound chemicals that reduce cells’ oxidation. Some are endogenous, while others are obtained from the diet (exogenous). Among them, polyphenols represent a very large proportion of micronutrients provided by our diet. They are becoming increasingly important, particularly caused of their effects of natural antioxidants. The purpose of the survey is to collect as much information on the consumption of certain foods that contain polyphenols end to know the daily consumption of a sample of 200 subjects taken at random in the Constantine. The questionnaire developed has two main components: a first component summarizes information on the identification of the interviewee, his health, risk factors and sedentary behavior. The second part contains information on foods consumed containing polyphenolic compounds, drawn from the database of the site phenol -explorer (http:// www. Phenol-explorer.eu/contents/total? Food- id = aa1). He also discussed in addition to the quantitative aspect and some processing that may affect the polyphenol composition of foods. From the results obtained, we run down the following key points: For daily consumption, 76% of subjects surveyed consume vegetables, 48% consume fruits, 39% and 20% drink drinks and herbal teas. Consumption of vegetables, fruits and beverages depends on the price, while the taste is not the primary factor in daily consumption of herbal teas. The sick patients consume fewer fresh fruits and vegetables and envelopes, more preserved foods, have more risk factors compared to healthy subjects. Regarding the consumption of polyphenols majority of respondents (75%) consumption complies with the standard (1g per day) which 2,75% corresponds to sick patients and 92,55% with healthy subjects. Among subjects with the standard lower consumption (25%), 97,43% corresponds to sick patients and 7,45% corresponds to healthy subjects. A weak correlation is found between the consumption of polyphenols and health, A weak correlation is found between the consumption of polyphenols and health. Diplôme : Magistère En ligne : ../theses/agronomie/BEC6482.pdf Format de la ressource électronique : pdf Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=9543 Enquête sur la consommation des polyphénols auprès d’un échantillon de 200 personnes de la région de Constantine [texte imprimé] / Fatima Zohra Becila, Auteur ; Malika Barkat, Directeur de thèse . - constantine (Route ain el bey, Algérie) : Université Constantine 1, 2014 . - 104 f. ; 30 cm. 2 copies imprimées disponibles Langues : Français (fre) Tags : Free radicals  oxidative stress  antioxidants  polyphenols  health  nutrition  radicaux libres  apport journalier  polyphénols  santé  alimentation  ?????? ?????  ???????  ?????? ???????  ????? ?????????  ????? Index. décimale : 640 Industrie Alimentaire Résumé : The organism produces free radicals daily. They may result from the action of certain chemical components of our environment (X-rays and UV light) of air pollutants (N, NO2), drugs, smoke, tobacco, alcohol, dietary errors. Oxidative stress due to free radicals causes tissue damage mainly by oxidation of proteins, DNA or lipids; it is involved in many diseases such as trigger or associated with the development of complications. Antioxidants are compound chemicals that reduce cells’ oxidation. Some are endogenous, while others are obtained from the diet (exogenous). Among them, polyphenols represent a very large proportion of micronutrients provided by our diet. They are becoming increasingly important, particularly caused of their effects of natural antioxidants. The purpose of the survey is to collect as much information on the consumption of certain foods that contain polyphenols end to know the daily consumption of a sample of 200 subjects taken at random in the Constantine. The questionnaire developed has two main components: a first component summarizes information on the identification of the interviewee, his health, risk factors and sedentary behavior. The second part contains information on foods consumed containing polyphenolic compounds, drawn from the database of the site phenol -explorer (http:// www. Phenol-explorer.eu/contents/total? Food- id = aa1). He also discussed in addition to the quantitative aspect and some processing that may affect the polyphenol composition of foods. From the results obtained, we run down the following key points: For daily consumption, 76% of subjects surveyed consume vegetables, 48% consume fruits, 39% and 20% drink drinks and herbal teas. Consumption of vegetables, fruits and beverages depends on the price, while the taste is not the primary factor in daily consumption of herbal teas. The sick patients consume fewer fresh fruits and vegetables and envelopes, more preserved foods, have more risk factors compared to healthy subjects. Regarding the consumption of polyphenols majority of respondents (75%) consumption complies with the standard (1g per day) which 2,75% corresponds to sick patients and 92,55% with healthy subjects. Among subjects with the standard lower consumption (25%), 97,43% corresponds to sick patients and 7,45% corresponds to healthy subjects. A weak correlation is found between the consumption of polyphenols and health, A weak correlation is found between the consumption of polyphenols and health. Diplôme : Magistère En ligne : ../theses/agronomie/BEC6482.pdf Format de la ressource électronique : pdf Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=9543

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L’effet protecteur des antioxydants naturels dans l’intoxication du mercure chez le rat Albinos Wistar / Ahlem Bahi  

Public ISBD Titre : L’effet protecteur des antioxydants naturels dans l’intoxication du mercure chez le rat Albinos Wistar : (Aspects biochimiques, immunologiques et histologiques). Type de document : texte imprimé Auteurs : Ahlem Bahi, Auteur ; Youcef Necib, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2015 Format : 30 cm. Note générale : 2 copies imprimées disponibles Langues : Français (fre) Tags : Mercure  Huile d’argan  Sélénium  Stress oxydatif  Argania Spinosa  antioxydants  Mercury  Argan Oil  Selenium  Oxidative Stress  antioxidants  ?????????  ??????? ????????  ??? ???????  ?????? Index. décimale : 570 Sciences de la vie. Biologie Résumé : The present study aimed to evaluate the protective effect of argan oil and selenium against oxidative stress induced by mercury. For this reason, a phytochemical study of antioxidant tested in vitro was performed on argan oil to estimate its expected effect. The results showed the presence of phenolic compounds in a very high concentration. The evaluation of power scavenger argan oil is more active with IC50 = 13.33 ± 1.3, and in vivo on Albino Wistar rats were treated with mercury alone or combined with argan oil and selenium, for a period of three weeks, the blood is then withdrawn and the rats are sacrificed the various parameters are determined. From the analysis of our results, we observed a significant reduction in weight gain during treatment with mercury alone or combined with argan oil and selenium, but no clear change in the relative weight of liver, kidney or spleen was obtained. The results also showed significant changes in biochemical parameters, immunological and haematological. Characterized primarily by a significant increase in serum glucose, urea, creatinine, uric acid, total and direct bilirubin, total lipids, cholesterol, triglyceride, conjugated diene and the enzymatic activity of AST, ALT, LDH and PAL .dropoff window Whereas serum concentrations of albumin and total protein were reduced in treated rats compared to mercury control animals. Results also show immunological and haematological toxicity especially among the treated groups the pure mercury, an increase in serum IL-1, IL-6 and TNF and elevated white blood cell count, decreased red blood cell levels, hemoglobin concentration the percentage of hematocrit and phagocytic activity during treatment with mercury. Thus the treatment of the rats with the mercury causes a reduction in the plasma antioxidant capacity characterized by decrease in the serum concentration of vitamin E and C and rate of DPPH and thiols. We also observed that the results obtained highlight the detoxifier potential expressed by the decrease in erythrocyte glutathione levels, liver and kidney, metallothionein, the enzymatic activity of the antioxidant system SOD, GPx, GST and catalase and increased in lipid peroxidation expressed by the high levels of plasma MDA, erythrocyte, liver and kidney. Also the results clearly showed substantive alterations of tissue studies in comparison with the control, with hepatocyte cytolysis, hepatic necrosis and tubular degeneration with necrosis of the kidneys. Furthermore supplementation argan oil and selenium changed the toxic effects of mercury and decreased histological alterations and showed that both antioxidants are effective against oxidative stress induced by mercury Diplôme : Doctorat en sciences En ligne : ../theses/biologie/BAH6696.pdf Format de la ressource électronique : pdf Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=9928 L’effet protecteur des antioxydants naturels dans l’intoxication du mercure chez le rat Albinos Wistar : (Aspects biochimiques, immunologiques et histologiques). [texte imprimé] / Ahlem Bahi, Auteur ; Youcef Necib, Directeur de thèse . - [S.l.] : جامعة الإخوة منتوري قسنطينة, 2015 . -  ; 30 cm. 2 copies imprimées disponibles Langues : Français (fre) Tags : Mercure  Huile d’argan  Sélénium  Stress oxydatif  Argania Spinosa  antioxydants  Mercury  Argan Oil  Selenium  Oxidative Stress  antioxidants  ?????????  ??????? ????????  ??? ???????  ?????? Index. décimale : 570 Sciences de la vie. Biologie Résumé : The present study aimed to evaluate the protective effect of argan oil and selenium against oxidative stress induced by mercury. For this reason, a phytochemical study of antioxidant tested in vitro was performed on argan oil to estimate its expected effect. The results showed the presence of phenolic compounds in a very high concentration. The evaluation of power scavenger argan oil is more active with IC50 = 13.33 ± 1.3, and in vivo on Albino Wistar rats were treated with mercury alone or combined with argan oil and selenium, for a period of three weeks, the blood is then withdrawn and the rats are sacrificed the various parameters are determined. From the analysis of our results, we observed a significant reduction in weight gain during treatment with mercury alone or combined with argan oil and selenium, but no clear change in the relative weight of liver, kidney or spleen was obtained. The results also showed significant changes in biochemical parameters, immunological and haematological. Characterized primarily by a significant increase in serum glucose, urea, creatinine, uric acid, total and direct bilirubin, total lipids, cholesterol, triglyceride, conjugated diene and the enzymatic activity of AST, ALT, LDH and PAL .dropoff window Whereas serum concentrations of albumin and total protein were reduced in treated rats compared to mercury control animals. Results also show immunological and haematological toxicity especially among the treated groups the pure mercury, an increase in serum IL-1, IL-6 and TNF and elevated white blood cell count, decreased red blood cell levels, hemoglobin concentration the percentage of hematocrit and phagocytic activity during treatment with mercury. Thus the treatment of the rats with the mercury causes a reduction in the plasma antioxidant capacity characterized by decrease in the serum concentration of vitamin E and C and rate of DPPH and thiols. We also observed that the results obtained highlight the detoxifier potential expressed by the decrease in erythrocyte glutathione levels, liver and kidney, metallothionein, the enzymatic activity of the antioxidant system SOD, GPx, GST and catalase and increased in lipid peroxidation expressed by the high levels of plasma MDA, erythrocyte, liver and kidney. Also the results clearly showed substantive alterations of tissue studies in comparison with the control, with hepatocyte cytolysis, hepatic necrosis and tubular degeneration with necrosis of the kidneys. Furthermore supplementation argan oil and selenium changed the toxic effects of mercury and decreased histological alterations and showed that both antioxidants are effective against oxidative stress induced by mercury Diplôme : Doctorat en sciences En ligne : ../theses/biologie/BAH6696.pdf Format de la ressource électronique : pdf Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=9928

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دراسة تأثير الاسمد العضوية الطبيعية المختلفة ومستوى النتروجين في نمو و انتاجيةالبطاطا صنف سبونتا)Solanum tuberosum L.)في منطقة وادي سوف / الجيلاني غمام عمارة  

Public ISBD Titre : دراسة تأثير الاسمد العضوية الطبيعية المختلفة ومستوى النتروجين في نمو و انتاجيةالبطاطا صنف سبونتا)Solanum tuberosum L.)في منطقة وادي سوف Type de document : texte imprimé Auteurs : الجيلاني غمام عمارة, Auteur ; محمد مراد السنوسي, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2016 Importance : 215 ورقة. Format : 30 سم. Note générale : 2 copies imprimes disponibles Langues : Arabe (ara) Tags : Potato  organic fertilizer  vegetative nitrogen  growth  productivity  protein  antioxidants  ???????  ??????? ???????  ?????????  ????? ??????  ????????  ?????? ??????? Index. décimale : 570 بيولوجيا Résumé : The experiments of this study were conducted at the region of Hassi khalifa, El-Oued, during the agricultural seasons 2010, 2011 and 2013. The objectives of this study were to investigate the effects of three kinds of organic manure (chicken, sheep and mixed manure chicken and sheep1/1 w/w) with three levels nitrogen for each one (1, 2, 3 kg/h protifert manure ) on the growth and yields of potato. These were compared with control and common fertilization treatment applied by the potato farmers (chicken manure + chemical manure N P k). A Factorial Randomized Complete Block Design (F-RCBD) was selected for the three experiments. Each experiment contained 11 treatments for each treatment with three replicates. The test of Least significant differences (LSD) was used to compare mean with 0.05 levels. In general results of the three experiments could be summarized as follow: - Physiological qualities were no significantly increased in terms of (Ratio and speed emergence, photosynthetic efficiency, relative water content and chlorophyll percentage). As a results of organic manure utilization and addition of three levels nitrogen as compared to untreated control during growing seasons. The results showed the greatest increase at the treatment of chicken manure either alone or mixed with sheep manure with these levels nitrogen in physiological qualities. - The results of vegetative growth reveled the following: Growth was significantly increased in terms of (foliage area, leaf area index, stem numbers/plant and plant height). Treatments chicken manure, chicken manure + 1kg/h protifert and mixed manure + 3kg/h of protifert appeared to be the most effective treatments in improving vegetative growth traits. - The results revealed that using the animal waste with levels nitrogen spraying on the leaves showed a significantly increase in treats of yield quantity terms (tuber number, tuber weight, yield of individual plant, total yield and marketable yield). Add to that treatments first level in chicken manure either alone or mixed better in tuber number, marketable yield. As for as the common fertilization treatment applied by the potato farmers and chicken manure +2 kg/h of protifert increased significantly tuber weight. - The results showed improvement in the chemical properties of the tuber using organic manure subsidized levels of nitrogen, the treatment chicken manure+ 1kg/h protifert lead to dry matter percentage, organic matter and starch percentage of tuber. Their treatments chicken manure + 2 kg/h of protifert better in protein, carbohydrate and nitrogen percentage of tuber. The results showed a significantly increase with treatments chicken manure alone or mixed + 2 kg/h of protifert in phosphor percentage of tuber. The treatment chicken manure +3 kg/h of protifert better in potassium content of the tuber. No significantly increase of treatment manure in anthocyanin and carotenoid content in tuber. - The results also showed a positive relationship between the phenols and flavonoids content, carbohydrates, potassium and phosphor in the tuber with nitrogen levels. In addition, it was observed an inverse relationship between the dry matter, starch and protein percentage. Diplôme : Doctorat en sciences En ligne : ../theses/biologie/AGHE4106.pdf Format de la ressource électronique : pdf Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10152 دراسة تأثير الاسمد العضوية الطبيعية المختلفة ومستوى النتروجين في نمو و انتاجيةالبطاطا صنف سبونتا)Solanum tuberosum L.)في منطقة وادي سوف [texte imprimé] / الجيلاني غمام عمارة, Auteur ; محمد مراد السنوسي, Directeur de thèse . - [S.l.] : جامعة الإخوة منتوري قسنطينة, 2016 . - 215 ورقة. ; 30 سم. 2 copies imprimes disponibles Langues : Arabe (ara) Tags : Potato  organic fertilizer  vegetative nitrogen  growth  productivity  protein  antioxidants  ???????  ??????? ???????  ?????????  ????? ??????  ????????  ?????? ??????? Index. décimale : 570 بيولوجيا Résumé : The experiments of this study were conducted at the region of Hassi khalifa, El-Oued, during the agricultural seasons 2010, 2011 and 2013. The objectives of this study were to investigate the effects of three kinds of organic manure (chicken, sheep and mixed manure chicken and sheep1/1 w/w) with three levels nitrogen for each one (1, 2, 3 kg/h protifert manure ) on the growth and yields of potato. These were compared with control and common fertilization treatment applied by the potato farmers (chicken manure + chemical manure N P k). A Factorial Randomized Complete Block Design (F-RCBD) was selected for the three experiments. Each experiment contained 11 treatments for each treatment with three replicates. The test of Least significant differences (LSD) was used to compare mean with 0.05 levels. In general results of the three experiments could be summarized as follow: - Physiological qualities were no significantly increased in terms of (Ratio and speed emergence, photosynthetic efficiency, relative water content and chlorophyll percentage). As a results of organic manure utilization and addition of three levels nitrogen as compared to untreated control during growing seasons. The results showed the greatest increase at the treatment of chicken manure either alone or mixed with sheep manure with these levels nitrogen in physiological qualities. - The results of vegetative growth reveled the following: Growth was significantly increased in terms of (foliage area, leaf area index, stem numbers/plant and plant height). Treatments chicken manure, chicken manure + 1kg/h protifert and mixed manure + 3kg/h of protifert appeared to be the most effective treatments in improving vegetative growth traits. - The results revealed that using the animal waste with levels nitrogen spraying on the leaves showed a significantly increase in treats of yield quantity terms (tuber number, tuber weight, yield of individual plant, total yield and marketable yield). Add to that treatments first level in chicken manure either alone or mixed better in tuber number, marketable yield. As for as the common fertilization treatment applied by the potato farmers and chicken manure +2 kg/h of protifert increased significantly tuber weight. - The results showed improvement in the chemical properties of the tuber using organic manure subsidized levels of nitrogen, the treatment chicken manure+ 1kg/h protifert lead to dry matter percentage, organic matter and starch percentage of tuber. Their treatments chicken manure + 2 kg/h of protifert better in protein, carbohydrate and nitrogen percentage of tuber. The results showed a significantly increase with treatments chicken manure alone or mixed + 2 kg/h of protifert in phosphor percentage of tuber. The treatment chicken manure +3 kg/h of protifert better in potassium content of the tuber. No significantly increase of treatment manure in anthocyanin and carotenoid content in tuber. - The results also showed a positive relationship between the phenols and flavonoids content, carbohydrates, potassium and phosphor in the tuber with nitrogen levels. In addition, it was observed an inverse relationship between the dry matter, starch and protein percentage. Diplôme : Doctorat en sciences En ligne : ../theses/biologie/AGHE4106.pdf Format de la ressource électronique : pdf Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10152

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L'effet de la plante Lifago dielsii sur le stress oxydatif/ nitrosatif et apoptotique hépatocytaire induit par les antituberculeux. / Samiya Baali  

Public ISBD Titre : L'effet de la plante Lifago dielsii sur le stress oxydatif/ nitrosatif et apoptotique hépatocytaire induit par les antituberculeux. Type de document : texte imprimé Auteurs : Samiya Baali, Auteur ; Souad Ameddah, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2018 Importance : 121 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles Langues : Français (fre) Tags : Isoniazide  Rifampicine  Lifago dielsii.  stress oxydatif et nitrosatif  Hépatoprotection  Isoniazid  Rifampicin  oxidative and nitrosative stress  Hepatic steatosis  Antioxidants  Hepato-protection  ????????????-????????  ?????? ??????  ????? ????? Index. décimale : 570 Sciences de la vie. Biologie Résumé : The purpose of this study is to evaluate in vivo the antioxidant and hepatoprotective effect of the butanolic extract of Lifago dielsii (BELD). The adult male Wistar Albino rats were force-fed with the BELD (250 mg / kg) for a period of 14 days and simultaneously received a combined treatment of the isoniazide (INH, 75mg / kg) and rifampicin (RIF, 150mg / kg). In vitro study of the antioxidant activity of BELD was also performed. Combination treatment of INH / RIF induces hepatic dysfunctions that have been revealed by; a significant increase in the level of serum enzymes (ALT, AST, ALP, LDH), alteration of lipid profile parameters (HDL, LDL, cholesterol, serum TG and hepatic TG ) as well as those of hepatic nitroso-oxidative stress (MDA, 4HNE, LHP, nitrosothiols, carbonylated proteins, nitric oxide) compared to the controls. Similarly, treatment with INH / RIF induces a significant reduction in the antioxidant activity of SOD, CAT, GST, GPx and POD and the level of GSH in the liver. Histologically, the combination of INH / RIF was able to induce hepatic steatosis. In contrast, the pretreatment of rats with BELD protects the liver against the toxic effect of metabolites generated by INH / RIF, thereby maintaining liver functions and balancing hepatic redox status. It appears from this in vivo study that BELD is endowed with antioxidant and hepatoprotective activity with a positive action on the restoration of INH / RIF-induced steatosis. The antioxidant effect of BELD has been studied in vitro by carrying out tests such as: reducing power, hydroxyl radical scavenging (HO°), total antioxidant capacity, iron chelating effect, nitrite anti-oxide effect (NO°) and Inhibition of lipid peroxidation by the ferric thiocyanate method. The results obtained show that this extract has a strong scavenger activity of radical HO° and NO°, as well as a strong reductive and inhibitory capacity of lipid peroxidation. In conclusion, the study realized valid the safety and effectiveness of the plant lifago dielsii. Which is a plant resulting from traditional Algerian medicine. The results obtained also support the therapeutic potential of the Butanolic extract of this plant, proving that its extracts and bioactive compounds can be developed as a new natural product for the prevention of liver injuries. Diplôme : Doctorat En ligne : ../theses/biologie/BAA7283.pdf Format de la ressource électronique : pdf Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10898 L'effet de la plante Lifago dielsii sur le stress oxydatif/ nitrosatif et apoptotique hépatocytaire induit par les antituberculeux. [texte imprimé] / Samiya Baali, Auteur ; Souad Ameddah, Directeur de thèse . - [S.l.] : جامعة الإخوة منتوري قسنطينة, 2018 . - 121 f. ; 30 cm. 2 copies imprimées disponibles Langues : Français (fre) Tags : Isoniazide  Rifampicine  Lifago dielsii.  stress oxydatif et nitrosatif  Hépatoprotection  Isoniazid  Rifampicin  oxidative and nitrosative stress  Hepatic steatosis  Antioxidants  Hepato-protection  ????????????-????????  ?????? ??????  ????? ????? Index. décimale : 570 Sciences de la vie. Biologie Résumé : The purpose of this study is to evaluate in vivo the antioxidant and hepatoprotective effect of the butanolic extract of Lifago dielsii (BELD). The adult male Wistar Albino rats were force-fed with the BELD (250 mg / kg) for a period of 14 days and simultaneously received a combined treatment of the isoniazide (INH, 75mg / kg) and rifampicin (RIF, 150mg / kg). In vitro study of the antioxidant activity of BELD was also performed. Combination treatment of INH / RIF induces hepatic dysfunctions that have been revealed by; a significant increase in the level of serum enzymes (ALT, AST, ALP, LDH), alteration of lipid profile parameters (HDL, LDL, cholesterol, serum TG and hepatic TG ) as well as those of hepatic nitroso-oxidative stress (MDA, 4HNE, LHP, nitrosothiols, carbonylated proteins, nitric oxide) compared to the controls. Similarly, treatment with INH / RIF induces a significant reduction in the antioxidant activity of SOD, CAT, GST, GPx and POD and the level of GSH in the liver. Histologically, the combination of INH / RIF was able to induce hepatic steatosis. In contrast, the pretreatment of rats with BELD protects the liver against the toxic effect of metabolites generated by INH / RIF, thereby maintaining liver functions and balancing hepatic redox status. It appears from this in vivo study that BELD is endowed with antioxidant and hepatoprotective activity with a positive action on the restoration of INH / RIF-induced steatosis. The antioxidant effect of BELD has been studied in vitro by carrying out tests such as: reducing power, hydroxyl radical scavenging (HO°), total antioxidant capacity, iron chelating effect, nitrite anti-oxide effect (NO°) and Inhibition of lipid peroxidation by the ferric thiocyanate method. The results obtained show that this extract has a strong scavenger activity of radical HO° and NO°, as well as a strong reductive and inhibitory capacity of lipid peroxidation. In conclusion, the study realized valid the safety and effectiveness of the plant lifago dielsii. Which is a plant resulting from traditional Algerian medicine. The results obtained also support the therapeutic potential of the Butanolic extract of this plant, proving that its extracts and bioactive compounds can be developed as a new natural product for the prevention of liver injuries. Diplôme : Doctorat En ligne : ../theses/biologie/BAA7283.pdf Format de la ressource électronique : pdf Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10898

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