3 résultat(s) recherche sur le tag 'Antifungal'    

Caractérisation chimique des principes à effet antidermatophyte des racines d'anacyclus L. / Souad Hamimed  

Public ISBD Titre : Caractérisation chimique des principes à effet antidermatophyte des racines d'anacyclus L. Type de document : texte imprimé Auteurs : Souad Hamimed ; Abdelmalik Belkhiri, Directeur de thèse ; Université Mentouri, Editeur scientifique Année de publication : 2009 Importance : 138 f. Note générale : 01 Disponible à la salle de recherche 02 Disponibles au magazin de la B.U.C. 01 CD Langues : Français (fre) Catégories : Français - Anglais Chimie Tags : Anacyclus pyrethrum  Racines  Asteraceae  Criblage phytochimique  Bioactivités antifongiques  Triterpènes pentacycliques et coumarines  roots  phytochemical screening  bio guided isolation  antifungal  pentacyclic triterpenes and coumarins  m?????? ????????(  ????  Asteraceae????? ???? ????????  ????? ????????  ?? ???????? ????????????????? ??? ????? ??????? ? ?????????? ? Index. décimale : 540 Chimie et sciences connexes Résumé : A preliminary biological evaluation of Anacyclus pyrethrum roots (Asteraceae) for antifungal effect localized a potent activity in the dichloromethane (DCM) extract. Bio guided fractionation of DCM active extract able us to track down a major activity in enriched fractions of triterpenes and alkamides. From the triterpene fraction, four compounds were isolated, from which two were formally identified as pentacyclic triterpenes. From the crude alcoholic extract of the roots, also investigated in this work, four products were isolated, one of which is a pyranocoumarin, and the other three compounds were identified as a phenylpropane derivatives. The nature of these phenylpropane, probably of lignan type, is under investigation. From the chemical point of view, the results obtained in this work provide a better understanding of secondary metabolism in the roots of A. pyrethrum. The metabolic profile of the roots is characterized by the presence of pentacyclic triterpenes, phenylpropane derivatives, coumarins and alkamides. Besides the already reported alkamides, the other types of secondary metabolites are reported for the first time in this species. From the biological point of view, the results obtained by bioguided fractionation allowed to track a significant antifungal activity in the moderately polar fractions, mainly containing triterpenes and alkamides compounds. Diplôme : Magistère En ligne : ../theses/chimie/HAM5430.pdf Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=3795 Caractérisation chimique des principes à effet antidermatophyte des racines d'anacyclus L. [texte imprimé] / Souad Hamimed ; Abdelmalik Belkhiri, Directeur de thèse ; Université Mentouri, Editeur scientifique . - 2009 . - 138 f. 01 Disponible à la salle de recherche 02 Disponibles au magazin de la B.U.C. 01 CD Langues : Français (fre) Catégories : Français - Anglais Chimie Tags : Anacyclus pyrethrum  Racines  Asteraceae  Criblage phytochimique  Bioactivités antifongiques  Triterpènes pentacycliques et coumarines  roots  phytochemical screening  bio guided isolation  antifungal  pentacyclic triterpenes and coumarins  m?????? ????????(  ????  Asteraceae????? ???? ????????  ????? ????????  ?? ???????? ????????????????? ??? ????? ??????? ? ?????????? ? Index. décimale : 540 Chimie et sciences connexes Résumé : A preliminary biological evaluation of Anacyclus pyrethrum roots (Asteraceae) for antifungal effect localized a potent activity in the dichloromethane (DCM) extract. Bio guided fractionation of DCM active extract able us to track down a major activity in enriched fractions of triterpenes and alkamides. From the triterpene fraction, four compounds were isolated, from which two were formally identified as pentacyclic triterpenes. From the crude alcoholic extract of the roots, also investigated in this work, four products were isolated, one of which is a pyranocoumarin, and the other three compounds were identified as a phenylpropane derivatives. The nature of these phenylpropane, probably of lignan type, is under investigation. From the chemical point of view, the results obtained in this work provide a better understanding of secondary metabolism in the roots of A. pyrethrum. The metabolic profile of the roots is characterized by the presence of pentacyclic triterpenes, phenylpropane derivatives, coumarins and alkamides. Besides the already reported alkamides, the other types of secondary metabolites are reported for the first time in this species. From the biological point of view, the results obtained by bioguided fractionation allowed to track a significant antifungal activity in the moderately polar fractions, mainly containing triterpenes and alkamides compounds. Diplôme : Magistère En ligne : ../theses/chimie/HAM5430.pdf Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=3795

Exemplaires (1)

Code-barres	Cote	Support	Localisation	Section	Disponibilité
HAM/5430	HAM/5430	Thèse	Bibliothèque principale	Thèses	Disponible

Etude phytochimique et valorisation biologique des deux plantes, Genista quadriflora Munby (Fabaceae) et Convolvulus tricolor L. (Convolvulaceae) / Nassira Kacem  

Public ISBD Titre : Etude phytochimique et valorisation biologique des deux plantes, Genista quadriflora Munby (Fabaceae) et Convolvulus tricolor L. (Convolvulaceae) Type de document : texte imprimé Auteurs : Nassira Kacem, Auteur ; Salah Rhouati, Directeur de thèse ; Kurt Hostettmann, Directeur de thèse Editeur : constantine [Algérie] : Université Constantine 1 Année de publication : 2015 Importance : 299 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles Langues : Français (fre) Catégories : Français - Anglais Chimie Tags : Genista  Convolvulus  alcaloïdes  acides caféoylquiniques  sesquiterpènes  flavonoïdes  HPLC  MPLC  CPC  ESIMS  GC/EIMS  HR-MS/TOF  Q-TRAP  MSn  RMN-2D  leishmanicide  antipaludique  antibactérienne  antifongique  antiradicalaire  acétylcholinestérase  alkaloids  caffeoylquinic acids  sesquiterpenoids  flavonoids  antileishmanial  antimalarial  antibacterial  antifungal  antiradical  acetylcholinesterase  ???????  ????? ???????????  ????????????  ??????????  ???? ??????? ???? ????????  ???? ?????  ???? ??????? ??????????????  ???? ????????  ???? ????????? Index. décimale : 540 Chimie et sciences connexes Résumé : This work was focused on two Algerian plants, the endemic species Genista quadriflora Munby (Fabaceae) and the species Convolvulus tricolor (Convolvulaceae). The study of the alkaloid profile of G. quadriflora by GC/EIMS allowed the identification of twenty compounds, among which ten are newly registered for the genus. We indicate the presence of: • Thirteen quinolizidine alkaloids • Five piperidine alkaloids • One nicotinic alkaloid, in addition to a nicotinic acid derivative. The investigation of the G. quadriflora essential oil has lead to the identification of 222 compounds,of which 197 are reported for the first time in the genus. This oil is mainly composed of terpenoids(66.85%) with a prevalence of sesquiterpenoids (65.18%). The major compounds are cited as: • Salvial-4 (14) - in-1-one; germacra-4 (15), 5, 10 (14) - trien-1-α-ol; amorpha-4, 9-dien-2- ol; muurolan-4, 7-peroxide. Also, twenty two compounds (caffeoylquinic acids, flavonoids, coumarin, phenol acid) were isolated from C. tricolor and G. quadriflora. All these compounds are reported for the first time in the studied species. The structural determination was carried out by mass spectrometry in electronic impact EIMS, by electrospray ESIMS, by high-resolution mass spectrometry HRMS, by time of flight HR-TOFMS, and by mass spectrometry high-resolution tandem MSn. In addition, we used NMR-1D and 2D spectroscopy. The second part of our work was an in vitro evaluation of the biological activities such as: • antileishmanial activity, antimalarial activity, antifungal and antibacterial activities, antioxidant activity against the DPPH, and the activity towards the enzyme acetylcholinesterase. The various tests carried out during this work have leads to tracks quite interesting especially for: • Samples of Convolvulus tricolor with inhibitions of the parasitic activity going from 89 to 99% by quite low rates of toxicity indicating their good selective activity on the parasites. • The alkaloids extract resulting from the air parts of Genista quadriflora for which the bacteria type Pseudomonas aeruginosa had a very particular sensitivity. Diplôme : Doctorat en sciences En ligne : ../theses/chimie/KAC6789.pdf Format de la ressource électronique : pdf Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=9979 Etude phytochimique et valorisation biologique des deux plantes, Genista quadriflora Munby (Fabaceae) et Convolvulus tricolor L. (Convolvulaceae) [texte imprimé] / Nassira Kacem, Auteur ; Salah Rhouati, Directeur de thèse ; Kurt Hostettmann, Directeur de thèse . - constantine (Route ain el bey, Algérie) : Université Constantine 1, 2015 . - 299 f. ; 30 cm. 2 copies imprimées disponibles Langues : Français (fre) Catégories : Français - Anglais Chimie Tags : Genista  Convolvulus  alcaloïdes  acides caféoylquiniques  sesquiterpènes  flavonoïdes  HPLC  MPLC  CPC  ESIMS  GC/EIMS  HR-MS/TOF  Q-TRAP  MSn  RMN-2D  leishmanicide  antipaludique  antibactérienne  antifongique  antiradicalaire  acétylcholinestérase  alkaloids  caffeoylquinic acids  sesquiterpenoids  flavonoids  antileishmanial  antimalarial  antibacterial  antifungal  antiradical  acetylcholinesterase  ???????  ????? ???????????  ????????????  ??????????  ???? ??????? ???? ????????  ???? ?????  ???? ??????? ??????????????  ???? ????????  ???? ????????? Index. décimale : 540 Chimie et sciences connexes Résumé : This work was focused on two Algerian plants, the endemic species Genista quadriflora Munby (Fabaceae) and the species Convolvulus tricolor (Convolvulaceae). The study of the alkaloid profile of G. quadriflora by GC/EIMS allowed the identification of twenty compounds, among which ten are newly registered for the genus. We indicate the presence of: • Thirteen quinolizidine alkaloids • Five piperidine alkaloids • One nicotinic alkaloid, in addition to a nicotinic acid derivative. The investigation of the G. quadriflora essential oil has lead to the identification of 222 compounds,of which 197 are reported for the first time in the genus. This oil is mainly composed of terpenoids(66.85%) with a prevalence of sesquiterpenoids (65.18%). The major compounds are cited as: • Salvial-4 (14) - in-1-one; germacra-4 (15), 5, 10 (14) - trien-1-α-ol; amorpha-4, 9-dien-2- ol; muurolan-4, 7-peroxide. Also, twenty two compounds (caffeoylquinic acids, flavonoids, coumarin, phenol acid) were isolated from C. tricolor and G. quadriflora. All these compounds are reported for the first time in the studied species. The structural determination was carried out by mass spectrometry in electronic impact EIMS, by electrospray ESIMS, by high-resolution mass spectrometry HRMS, by time of flight HR-TOFMS, and by mass spectrometry high-resolution tandem MSn. In addition, we used NMR-1D and 2D spectroscopy. The second part of our work was an in vitro evaluation of the biological activities such as: • antileishmanial activity, antimalarial activity, antifungal and antibacterial activities, antioxidant activity against the DPPH, and the activity towards the enzyme acetylcholinesterase. The various tests carried out during this work have leads to tracks quite interesting especially for: • Samples of Convolvulus tricolor with inhibitions of the parasitic activity going from 89 to 99% by quite low rates of toxicity indicating their good selective activity on the parasites. • The alkaloids extract resulting from the air parts of Genista quadriflora for which the bacteria type Pseudomonas aeruginosa had a very particular sensitivity. Diplôme : Doctorat en sciences En ligne : ../theses/chimie/KAC6789.pdf Format de la ressource électronique : pdf Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=9979

Exemplaires (1)

Code-barres	Cote	Support	Localisation	Section	Disponibilité
KAC/6789	KAC/6789	Thèse	Bibliothèque principale	Thèses	Disponible

Phytochemical and biological studies of two Algerian medicinal plants / Farida Larit  

Public ISBD Titre : Phytochemical and biological studies of two Algerian medicinal plants : Cytisus villosus Pourr. (Fabaceae) and Hypericum afrum Lam. (Hypericaceae) Type de document : texte imprimé Auteurs : Farida Larit, Auteur ; Samira Benyahia, Directeur de thèse Editeur : جامعة الإخوة منتوري قسنطينة Année de publication : 2017 Importance : 353 f. Format : 30 cm. Note générale : 2 copies imprimées disponibles Langues : Anglais (eng) Catégories : Français - Anglais Chimie Tags : Hypericum  Cytisus  Secondary metabolites  Total phenolics  Antioxidant  Cytotoxicity  Antifungal  Antibacterial  Antimalarial  Antileishmanial  Activity  MAO-A and MAO-B  Docking  Simulation  Métabolites secondaires  Total phénoliques  Cytotoxicité  Antifongique  Antibactérienne  Antipaludique  Antileishmanienne  MAO-A et MAO-B  "MAO-A MAO-B Cytisus Hypericum ?????? ????????? ????????  ???? ???????  ???? ?????????  ???? ????????  ???? ?????????????" Index. décimale : 540 Chimie et sciences connexes Résumé : Natural products are important sources of novel therapeutic agents. Bioactive secondary metabolites isolated from natural sources, can act as drugs or as lead compounds for synthetic drugs. In our work, two plants have been studied; the endemic species of Hypericum afrum Lam.(Hypericaceae) and Cytisus villosus Pourr. (Fabaceae). Fractions of the aerial parts of these two plants have been screened in vitro for several biological assays including cannabinoid and opioid receptors agonist assays, antifungal, antibacterial, antimalarial, antileishmanial, antiproliferative, antioxidant, anti-inflammatory and MAO inhibition. The chloroform, ethyl acetate and n-butanol fractions of H. afrum showed significant antioxidant activity and potent antitrypanosomal activity against T. brucei. The n-butanol fraction of C. villosus showed highly potent antitrypanosomal activity against T. brucei. In addition, the ethyl acetate fractions of both plants showed potent inhibition of recombinant human monoamine oxidases (MAO-A and -B). A bioassay-guided fractionation paradigm has been used for the isolation of bioactive compounds of these plants and hence the subfractions that showed significant activity were further purified. This study led to the isolation and identification of 20 compounds, three of which belonging to phloroglucinols, terpenoids and isoflavonoids are new. The structures of the isolated compounds were elucidated through various spectroscopic methods, including high- resolution mass spectrometry, one and two-dimensional nuclear magnetic resonance spectroscopy. Computational study was carried out by conformational search and docking techniques to provide insight into the binding mode of molecules on the active site of MAO’s isoenzymes. Diplôme : Doctorat en sciences En ligne : ../theses/chimie/LAR7157.pdf Format de la ressource électronique : pdf Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10430 Phytochemical and biological studies of two Algerian medicinal plants : Cytisus villosus Pourr. (Fabaceae) and Hypericum afrum Lam. (Hypericaceae) [texte imprimé] / Farida Larit, Auteur ; Samira Benyahia, Directeur de thèse . - [S.l.] : جامعة الإخوة منتوري قسنطينة, 2017 . - 353 f. ; 30 cm. 2 copies imprimées disponibles Langues : Anglais (eng) Catégories : Français - Anglais Chimie Tags : Hypericum  Cytisus  Secondary metabolites  Total phenolics  Antioxidant  Cytotoxicity  Antifungal  Antibacterial  Antimalarial  Antileishmanial  Activity  MAO-A and MAO-B  Docking  Simulation  Métabolites secondaires  Total phénoliques  Cytotoxicité  Antifongique  Antibactérienne  Antipaludique  Antileishmanienne  MAO-A et MAO-B  "MAO-A MAO-B Cytisus Hypericum ?????? ????????? ????????  ???? ???????  ???? ?????????  ???? ????????  ???? ?????????????" Index. décimale : 540 Chimie et sciences connexes Résumé : Natural products are important sources of novel therapeutic agents. Bioactive secondary metabolites isolated from natural sources, can act as drugs or as lead compounds for synthetic drugs. In our work, two plants have been studied; the endemic species of Hypericum afrum Lam.(Hypericaceae) and Cytisus villosus Pourr. (Fabaceae). Fractions of the aerial parts of these two plants have been screened in vitro for several biological assays including cannabinoid and opioid receptors agonist assays, antifungal, antibacterial, antimalarial, antileishmanial, antiproliferative, antioxidant, anti-inflammatory and MAO inhibition. The chloroform, ethyl acetate and n-butanol fractions of H. afrum showed significant antioxidant activity and potent antitrypanosomal activity against T. brucei. The n-butanol fraction of C. villosus showed highly potent antitrypanosomal activity against T. brucei. In addition, the ethyl acetate fractions of both plants showed potent inhibition of recombinant human monoamine oxidases (MAO-A and -B). A bioassay-guided fractionation paradigm has been used for the isolation of bioactive compounds of these plants and hence the subfractions that showed significant activity were further purified. This study led to the isolation and identification of 20 compounds, three of which belonging to phloroglucinols, terpenoids and isoflavonoids are new. The structures of the isolated compounds were elucidated through various spectroscopic methods, including high- resolution mass spectrometry, one and two-dimensional nuclear magnetic resonance spectroscopy. Computational study was carried out by conformational search and docking techniques to provide insight into the binding mode of molecules on the active site of MAO’s isoenzymes. Diplôme : Doctorat en sciences En ligne : ../theses/chimie/LAR7157.pdf Format de la ressource électronique : pdf Permalink : https://bu.umc.edu.dz/md/index.php?lvl=notice_display&id=10430

Exemplaires (1)

Code-barres	Cote	Support	Localisation	Section	Disponibilité
LAR/7157	LAR/7157	Thèse	Bibliothèque principale	Thèses	Disponible